Molybdenum Nanoparticles as a Potential Topical Medication for Alopecia Treatment Through Antioxidant Pathways that Differ from Minoxidil

Xiao, Qin; Lu, Yongzhou; Yao, Wei; Gong, Chengchen; Jia, Chuanlong; Jin, Guojun; Guo, Jing; Qiu, T J; Jiang, Yebin; Huang, Min; Chu, Wenhua; Xu, Quangang; Xu, Nan

doi:10.2139/ssrn.4435549

2023

DOI: 10.2139/ssrn.4435549

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Molybdenum Nanoparticles as a Potential Topical Medication for Alopecia Treatment Through Antioxidant Pathways that Differ from Minoxidil

Qin Xiao

Yongzhou Lu

Wei Yao

et al.

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Nanodrug Delivery Strategies to Signaling Pathways in Alopecia

Wu,

2023

Mol. Pharmaceutics

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Over 50% of the global population suffers from hair loss. The mixed results in the treatment of hair loss reveal the limitations of conventional commercial topical drugs. One the one hand, the definite pathogenesis of hair loss is still an enigma. On the other hand, targeted drug carriers ensure the drug therapeutic effect and low side effects. This review highlights the organization and overview of nine crucial signaling pathways associated with hair loss, as well as the development of nanobased topical delivery systems loading the clinical drugs, which will fuel emerging hair loss treatment strategies.

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Nanodrug Delivery Strategies to Signaling Pathways in Alopecia

Wu,

2023

Mol. Pharmaceutics

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Clinical and preclinical approach in AGA treatment: a review of current and new therapies in the regenerative field

Pozo-Pérez,

Tornero-Esteban,

López-Bran

2024

Stem Cell Res Ther

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Androgenetic alopecia (AGA) is the most prevalent type of hair loss. Its morbility is mainly psychological although an increased incidence in melanoma has also been observed in affected subjects. Current drug based therapies and physical treatments are either unsuccessful in the long term or have relevant side effects that limit their application. Therefore, a new therapeutic approach is needed to promote regenerative enhancement alternatives. These treatment options, focused on the cellular niche restoration, could be the solution to the impact of dihydrotestosterone in the hair follicle microenvironment. In this context emerging regenerative therapies such as Platelet-rich plasma or Platelet-rich fibrine as well as hair follicle stem cells and mesenchymal stem cell based therapies and their derivatives (conditioned medium CM or exoxomes) are highlighting in the evolving landscape of hair restoration. Nanotechnology is also leading the way in AGA treatment through the design of bioinks and nanobiomaterials whose structures are being configuring in a huge range of cases by means of 3D bioprinting. Due to the increasing number and the rapid creation of new advanced therapies alternatives in the AGA field, an extended review of the current state of art is needed. In addition this review provides a general insight in current and emerging AGA therapies which is intented to be a guidance for researchers highlighting the cutting edge treatments which are recently gaining ground.

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Molybdenum Nanoparticles as a Potential Topical Medication for Alopecia Treatment Through Antioxidant Pathways that Differ from Minoxidil

Cited by 2 publications

References 0 publications

Nanodrug Delivery Strategies to Signaling Pathways in Alopecia

Nanodrug Delivery Strategies to Signaling Pathways in Alopecia

Clinical and preclinical approach in AGA treatment: a review of current and new therapies in the regenerative field

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