Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

Gogineni, Vedanjali; Oh, Joonseok; Waters, Amanda L.; Kelly, Michelle; Stone, Robert P.; Hamann, Mark T.

doi:10.3389/fmars.2020.00058

Cited by 7 publications

(7 citation statements)

References 28 publications

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“…Guanidine, an alkaloid that has cytotoxic properties and prevents EGF-Induced Neoplastic was isolated from Monachora pulchra (Dyshlovoy et al 2016). Gogineni et al (2020) A total of 3 fungal isolates were obtained from the Monanchora sponge. The small number of fungi isolated from Monanchora sp.…”

Section: Resultsmentioning

confidence: 99%

“…Guanidinederived alkaloids (Dyshlovoy et al 2016), showing the wide scope of biological activities, e.i. anti-parasitic (Santos et al 2015), anticancer and antibacterial (Gogineni et al 2020), antiviral (Hua et al 2007), antifungal (Arevabini et al 2014), andcytotoxic (El-Demerdash et al 2016). The potential sources of natural products in Indonesia so far have not been well explored.…”

Section: Introductionmentioning

confidence: 99%

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Potential of marine sponge-derived fungi in the aquaculture system

2021

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Abstract. Bahry MS, Radjasa OK, Trianto A. 2021. Potential of marine sponge-derived fungi in the aquaculture system. Biodiversitas 22: 2883-2892. Organic waste from aquaculture is one of the triggers of disease outbreaks and a decrease in water quality that urgently needs to be resolved. Indonesia has a high diversity of sponges including their associated microorganisms that potential in the field of biotechnology. This study aimed to determine the enzymatic and anti-vibrio activity of fungi associated with marine sponges and identify potential fungi. The specimen of sponges was collected from Samalona Island, South Sulawesi, Indonesia. The enzymatic and anti-vibrio assay was conducted by using the plug method and the activity was determined by a clear zone around the fungal isolates. Fungal identification was carried out molecularly using universal primers ITS1 and ITS4 and phylogenetic tree analysis. The fungal isolates were screened for the extracellular enzyme activity (amylase, cellulase, protease) and anti-vibrio activity against Vibrio parahaemolyticus, V. harveyi, and V. vulnificus). A total of three fungal isolates have been isolated from the sponge Monanchora sp. Isolate SL 3 SP 3.3 had potential enzymatic activities with Enzymatic Indeks (EI) 3.95±0.17 on amylase, 3.75±0.36 on cellulase, 5.38±0.30 on protease. The highest anti-vibrio activity was obtained against V. harveyi with an inhibition zone diameter of 4.82 ±0.37 mm. The results of fungal identification showed that isolate SL3SP3.3 had a sequence length of 638 bp and was closely related to Trichoderma reesei a.k.a Hypocrea jecorina with a similarity value of 99.69%.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential of marine sponge-derived fungi in the aquaculture system

2021

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“…Monanchocidin-A is a novel compound derived from sponges closely related to Monanchora species [ 62 ]. It has been tested in vitro using the NCI-60 Human Tumor Cell Lines Screen to investigate its potential anti-cancer activity.…”

Section: Marine Macro-organismsmentioning

confidence: 99%

“…The NCI-60 screen provided 60 cell cancer lines to evaluate the dose-response created by a particular drug, thus comparing and selecting compounds that are most selectively for cancer lines ( ; accessed on 14 July 2022). The melanoma cell lines used for the screening were LOX IMVI, MALME-3M, M14, MDA-MB-435, SK-MEL-2, SK-MEL-28, SK-MEL-5, UACC257, and UACC-62 [ 62 ]. This research demonstrated Monanchocidin-A anticancer potential, indicating a peculiar activity against melanoma cell lines [ 62 ].…”

Section: Marine Macro-organismsmentioning

confidence: 99%

Marine Compounds for Melanoma Treatment and Prevention

Montuori

Capalbo

Lauritano

2022

IJMS

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Melanoma is considered a multifactorial disease etiologically divided into melanomas related to sun exposure and those that are not, but also based on their mutational signatures, anatomic site, and epidemiology. The incidence of melanoma skin cancer has been increasing over the past decades with 132,000 cases occurring globally each year. Marine organisms have been shown to be an excellent source of natural compounds with possible bioactivities for human health applications. In this review, we report marine compounds from micro- and macro-organisms with activities in vitro and in vivo against melanoma, including the compound Marizomib, isolated from a marine bacterium, currently in phase III clinical trials for melanoma. When available, we also report active concentrations, cellular targets and mechanisms of action of the mentioned molecules. In addition, compounds used for UV protection and melanoma prevention from marine sources are discussed. This paper gives an overview of promising marine molecules which can be studied more deeply before clinical trials in the near future.

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“…Однако наиболее интересным в данном исследовании было открытие, что монанхоцидин избирательно ингибирует опухолевые клетки опасного ракового заболевания -меланомы. Все линии клеток меланомы демонстрировали чувствительность к действию этого вещества, показывая ингибирующую активность, при этом его ингибирующая активность на этих клетках превышала активность известного противоракового лекарства «Таксол» [5].…”

Section: новые биопрепараты для медициныunclassified

Molecular-biological and biomedical investigations in FEB RAS. Some modern results and perspectives of the marine natural products studies

Мищенко¹,

Федореев²,

Крылова³

et al. 2020

Вестник ДВО РАН

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Рассмотрены некоторые результаты молекулярно-биологических и биомедицинских исследований, выполненных в основном в 2019–2020 гг. В исследованиях принимали участие Тихоокеанский институт биоорганической химии им. Г.Б. Елякова ДВО РАН, другие институты ДВО РАН, Научно-исследовательский институт эпидемиологии и микробиологии им. Г.П. Сомова, а также научные организации из Республики Корея, Вьетнама, Германии и других стран. Some examples of the molecular studies on natural products and their medico-biological properties were discussed in this short review. All these studies were carried out in 2019–2020. G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Science, other scientific organizations of FEB RAS, G.P. Somov Research Institute of Epidemiology and Microbiology, as well as collaborators from foreign countries such as Republic of Korea, Socialistic Republic of Vietnam, Germany took also part in the investigation.

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Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

Cited by 7 publications

References 28 publications

Potential of marine sponge-derived fungi in the aquaculture system

Potential of marine sponge-derived fungi in the aquaculture system

Marine Compounds for Melanoma Treatment and Prevention

Molecular-biological and biomedical investigations in FEB RAS. Some modern results and perspectives of the marine natural products studies

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