Monascus pigments production, composition, bioactivity and its application: A review

Agboyibor, Clement; Kong, Weibao; Chen, Dong; Zhang, Aimei; Niu, Shiquan

doi:10.1016/j.bcab.2018.09.012

Cited by 110 publications

(66 citation statements)

References 110 publications

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“…The role of ammonium acetate is very clear in the production of monascorubramine with multi-fold increases in the initial days of fermentation. A previous study confirmed that the addition of ammonium in growth media enhanced the production of red pigments [51].…”

Section: Discussionsupporting

confidence: 68%

“…Furthermore, the results showed that different ammonium salts slightly influenced the yield of yellow pigment but production of red pigments was significantly enhanced [51]. In contrast to these studies, a research showed that when ammonium is added in growth media as ammonium chloride, it does not induce the pigment production to a higher extent in Monascus purpureus [52].…”

Section: Discussionmentioning

confidence: 82%

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Transfigured Morphology and Ameliorated Production of Six Monascus Pigments by Acetate Species Supplementation in Monascus ruber M7

Virk

Ramzan

Virk³

et al. 2020

Microorganisms

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Monascus species have been used for the production of many industrially and medically important metabolites, most of which are polyketides produced by the action of polyketide synthases that use acetyl-CoA and malonyl-CoA as precursors, and some of them are derived from acetate. In this study the effects of acetic acid, and two kinds of acetates, sodium acetate and ammonium acetate at different concentrations (0.1%, 0.25% and 0.5%) on the morphologies, biomasses, and six major Monascus pigments (MPs) of M. ruber M7 were investigated when M7 strain was cultured on potato dextrose agar (PDA) at 28 °C for 4, 8, 12 days. The results showed that all of the added acetate species significantly affected eight above-mentioned parameters. In regard to morphologies, generally the colonies transformed from a big orange fleecy ones to a small compact reddish ones, or a tightly-packed orange ones without dispersed mycelia with the increase of additives concentration. About the biomass, addition of ammonium acetate at 0.1% increased the biomass of M. ruber M7. With respect to six MPs, all acetate species can enhance pigment production, and ammonium acetate has the most significant impacts. Production of monascin and ankaflavin had the highest increase of 11.7-fold and 14.2-fold in extracellular contents at the 8th day when 0.1% ammonium acetate was supplemented into PDA. Intracellular rubropunctatin and monascorubrin contents gained 9.6 and 6.46-fold at the 8th day, when 0.1% ammonium acetate was added into PDA. And the extracellular contents of rubropunctamine and monascorubramine were raised by 1865 and 4100-fold at the 4th day when M7 grew on PDA with 0.5% ammonium acetate.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 82%

Transfigured Morphology and Ameliorated Production of Six Monascus Pigments by Acetate Species Supplementation in Monascus ruber M7

Virk

Ramzan

Virk³

et al. 2020

Microorganisms

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“…red, orange and yellow pigments. A total of six well-known pigment compounds are monascorubramine and rubropunctamine (red pigments), monascorubrin and rubropunctatin (orange pigments), monascin and ankaflavin (yellow pigments) (Feng et al, 2012;Srianta et al, 2014;Agboyibor et al, 2018). Until 2011, thirty-nine new pigment compounds have been identified (Feng et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Separation and analysis of Monascus yellow pigment produced on durian seed substrate

Srianta¹,

Nugerahani²,

Ristiarini³

2020

Food Res.

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This research was aimed to separate and analyse Monascus yellow pigment (MYP) with chromatography. MYP was in a mixture with red and orange pigments. MYP separation was performed in a silica gel column with eluent of ethyl acetate: ethanol: water = 90: 25: 4. The separated MYP were then subjected to analysis by using spectrophotometer, TLC, LC-PDA and LC-MS/MS. The results revealed that the separated MYP has a maximum absorption at 386 nm. Out of five MYP compounds detected by using LC-MS/MS, two of them were well known yellow pigment compounds, monascin and ankaflavin. Monascin and yellow II were the major pigment compounds in MYP.

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“…In recent years, the biosynthetic pathways involved in MPs and citrinin have been gradually revealed and understood. 22,23 However, the regulatory mechanisms of inorganic nitrogen on the biosynthesis of pigments and citrinin in Monascus spp. have not been systematically investigated.…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptomic analysis reveals the regulatory effects of inorganic nitrogen on the biosynthesis of Monascus pigments and citrinin

Hong

et al. 2020

RSC Adv.

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Monascus pigments production, composition, bioactivity and its application: A review

Cited by 110 publications

References 110 publications

Transfigured Morphology and Ameliorated Production of Six Monascus Pigments by Acetate Species Supplementation in Monascus ruber M7

Transfigured Morphology and Ameliorated Production of Six Monascus Pigments by Acetate Species Supplementation in Monascus ruber M7

Separation and analysis of Monascus yellow pigment produced on durian seed substrate

Comparative transcriptomic analysis reveals the regulatory effects of inorganic nitrogen on the biosynthesis of Monascus pigments and citrinin

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