Mondor’s disease

Abstract

Mondor's disease (MD) is a rare condition, which is considered a thrombophlebitis of the subcutaneous veins. It commonly occurs on the anterolateral thoracoabdominal wall, but it can also occur on the penis, groin, antecubital fossa and posterior cervical region. The clinical features are a sudden and typically asymptomatic onset of a cord-like induration, although some patients report a feeling of 'strain'. It is a self-limiting process that lasts a short period of time, which may be the reason why there are few reports about its diagnosis and treatment. Its pathogenesis has remained unclear, because of the lack of methods to reliably differentiate between veins and lymphatic vessels. Immunohistochemical staining for CD31 and D240 has been identified recently as the best method to distinguish small veins from lymphatic vessels, making it a valuable technique in diagnosing not only MD, but also many other diseases in which veins or lymphatic vessels are affected. MD has been associated with several systemic diseases such as breast cancer and hypercoagulability states, thus laboratory studies are recommended to exclude any possible systemic disorders. As this condition is usually a benign and self-limiting process, vigorous treatment is only recommended when the process is symptomatic or recurrent.

Enfermedad de Mondor reporte de caso

“…Si la sintomatología es recurrente, se debe pensar en una coagulopatía sistémica (4,10). Clínicamente se manifiesta como dolor, y algunas veces enrojecimiento de la piel que sigue el trayecto de la vena comprometida.…”

Exacerbation of Psoriasis Confirmed by Drug Challenge Test of Lithium Carbonate

“…The pathogenesis of the disease is unclear but related with vessel-wall damage, stasis and hypercoagulable state .Histopathological findings include obstructed or obliterated vasculitis [1,5] Clinically is characterized by subcutaneous tender, usually unilateral cord-like phlebitis commonly on the breast or anterior chest wall but it can also involve the penis, groin, antecubital fosse, and posterior cervical region. Most of the cases are idiopathic but trauma, surgery, excessive physical activity and rarely breast carcinoma have been considered a predisposing factor.…”

“…[1][2][3][4][5]Penile Mondor´s disease is a thrombosis of the dorsal superficial veins of the penis [6] The aetiology is unknown. It is rarely associated with viral infections [7,8] and to our knowledge the case in this report is the second case of MD in a patient with hepatitis C.…”

Penile Mondor’s Disease Induced by Vigorous Sexual Activity: Two Cases, Two Different Approaches

“…7 Immunohistochemical staining for CD31 and D240 was identified recently as the best method to distinguish small veins from lymphatic vessels; this method is used especially in the differential diagnosis of Mondor's disease to rule out other diseases in which veins or lymphatic vessels are affected. 8 Although observation and sexual abstinence are sufficient for most cases as in our second patient, several authors recommend anticoagulants, antibiotics and anti-inflammatory agents, local heparinoid ointment in acute and subacute stages, respectively. 1,4,9 Recanalization process was reported to last approximately 9 weeks.…”