Monitoramento epidemiológico da tuberculose em um hospital geral universitário

Gonçalves, Berenice das Dores; Cavalini, Luciana Tricai; Valente, Joaquim Gonçalves

doi:10.1590/s1806-37132010000300013

Cited by 12 publications

(17 citation statements)

References 9 publications

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“…However, it does not justify the complete negation of the disease's infectivity or the fact that biosecurity norms are rarely discussed in leprosy health services, unlike in the tuberculosis program. 1,2 …”

Section: Discussionmentioning

confidence: 99%

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Serology with ML Flow test in health professionals from three different states of Brazil

Calado

Magnanini

Moura

et al. 2013

An. Bras. Dermatol.

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BACKGROUND In highly endemic countries, transmission and sub-clinical infection of leprosy are likely and the disease manifests itself in individuals without any known close contact with a leprosy patient. Health workers are social contacts belonging to the same network (the Health System) and some of them share the same social environment (nursing assistants) as patients with known patients and / or carriers. OBJECTIVE To identify ML Flow seropositivity among health professionals. METHODS We conducted a cross-sectional study using a serological survey with the ML Flow test in 450 health professionals (doctors, nurses and nursing assistants), in order to detect seropositivity in areas of high and low endemicity in municipalities from three Brazilian states (RJ, MS and RS). RESULTS The results showed general 16% seropositivity, higher in low endemic areas, regardless of whether there was direct care for leprosy patients. Paradoxically, a statistical association was observed between the area studied and seropositivity, as the place with the lowest endemicity (CA) had the highest seropositivity rate (p = 0.033). CONCLUSION The authors suggest these results are associated with a presence of an unspecified link to bovine serum albumin (BSA), carrier of PGL-1 in the ML Flow test, and recommend expanded seroepidemiological research utilizing tests with human and bovine albumin.

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Section: Discussionmentioning

confidence: 99%

“…1,2 In addition, the known stigma associated with leprosy makes it difficult to know the actual number of health workers (HW) with the disease. They are considered social contacts of their patients, as some of them belong to the same network (the Health System).…”

Section: Introductionmentioning

confidence: 99%

Serology with ML Flow test in health professionals from three different states of Brazil

Calado

Magnanini

Moura

et al. 2013

An. Bras. Dermatol.

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“…Goncalves et al79 described the epidemiological monitoring of exposure to tuberculosis in a hospital environment and to analyze the profile of the disease in a general teaching hospital and suggest that the proposed indicators can potentially help standardize epidemiological monitoring procedures for nosocomial tuberculosis. Gupta et al80 In developing countries, sputum smear microscopy is the main tool for pulmonary tuberculosis case finding.…”

Section: Introductionmentioning

confidence: 99%

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

Patel¹,

Caramelli²,

Gomes³

2011

Clinics

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Recent original scientific contributions published in selected Brazilian periodicals and classifiable under cardiovascular and pulmonary subject categories cover a wide range of sub specialties, both clinical and exprimental. Because they appear in journals with only recently enhanced visibility, we have decided to highlight a number of specific items appeared in four Brazilian journals, because we understand that this is an important subsidy to keep our readership adequately informed. These papers cover extensive sub-areas in both fields.

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“…(5) In that same study, it was observed that, of the 68 pyrazinamidereported in other studies. (13)(14)(15)(16)(17) With regard to age, the literature provides mixed findings. In this sample, tuberculosis primarily affected those between 18 and 39 years of age, a finding that was also reported in a survey conducted in Rio de Janeiro, Brazil.…”

Section: Resultsmentioning

confidence: 99%

Resistência primária e adquirida à pirazinamida em pacientes com tuberculose pulmonar atendidos em um hospital de referência no Recife

2012

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Objective: To determine primary and acquired resistance to pyrazinamide in Mycobacterium tuberculosis strains isolated in sputum samples from patients with pulmonary tuberculosis. Methods: This was a prospective, descriptive study conducted between April and November of 2011 at a referral hospital for tuberculosis in the city of Recife, Brazil. Cultures, drug sensitivity tests, and tests of pyrazinamidase activity were conducted in a private laboratory in Recife. Results: Of the 71 patients included in the study, 37 were treatment-naïve and 34 represented cases of retreatment. Pyrazinamide-resistant strains were isolated in 14 (41.2%) of the 34 patients who had previously been treated for tuberculosis and in none of the 37 treatment-naïve patients. Of the 14 isolates, 10 (90.9%) tested negative for pyrazinamidase activity. A total of 60 isolates tested positive for pyrazinamidase activity. Of those, 56 (93.3%) were found to be sensitive to pyrazinamide. Conclusions: The high frequency of pyrazinamide-resistant strains (41.2%) in patients previously treated for tuberculosis highlights the need for drug susceptibility testing prior to the adoption of a new treatment regimen.Keywords: Mycobacterium tuberculosis; Pyrazinamide; Tuberculosis, multidrug-resistant. ResumoObjetivo: Verificar a resistência primária e adquirida à pirazinamida em cepas de Mycobacterium tuberculosis provenientes de amostras de escarro de pacientes com tuberculose pulmonar. Métodos: Estudo prospectivo e descritivo realizado no período entre abril e novembro de 2011 em um hospital de referência para o tratamento de tuberculose em Recife (PE). Culturas, testes de sensibilidade a fármacos e testes da pirazinamidase foram realizados em um laboratório particular na mesma cidade. Resultados: Dos 71 pacientes incluídos no estudo, 37 eram virgens de tratamento e 34 eram casos de retratamento. Desses, 0 (0,0%) e 14 (41,2%), respectivamente, apresentaram cepas resistentes à pirazinamida. Desses 14 isolados, 10 (90,9%) apresentaram resultados negativos no teste da pirazinamidase. Dos 60 isolados que apresentaram resultados positivos para o teste da pirazinamidase, 56 (93,3%) eram sensíveis à pirazinamida. Conclusões: A elevada frequência de cepas resistentes à pirazinamida em pacientes em retratamento da tuberculose destaca a necessidade da realização de testes de sensibilidade à pirazinamida antes de se escolher um novo esquema de tratamento.Descritores: Mycobacterium tuberculosis; Pirazinamida; Tuberculose resistente a múltiplos medicamentos.

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Monitoramento epidemiológico da tuberculose em um hospital geral universitário

Abstract: The proposed indicators can potentially help standardize epidemiological monitoring procedures for nosocomial tuberculosis, and the epidemiological profile described in this study can contribute to a better understanding of the situation of tuberculosis in Brazil.

Cited by 12 publications

References 9 publications

Serology with ML Flow test in health professionals from three different states of Brazil

Serology with ML Flow test in health professionals from three different states of Brazil

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

Resistência primária e adquirida à pirazinamida em pacientes com tuberculose pulmonar atendidos em um hospital de referência no Recife

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