DoD, agency and commercial operations centers that manage complex enterprise systems face the problem of protecting both the systems and the data they carry against cyber attacks while, at the same time, providing high quality end-to-end services that meet service level agreements and help ensure mission success. Presently there exists no comprehensive tool suite that encompasses the procedures, methods, and policies to provide an effective enterprise cyber security monitoring and management solution. This paper provides a basis from which to fill that void by introducing a new framework for monitoring and managing cyber security events in complex systems. We demonstrate application of this framework using several realistic scenarios.