Monitoring disease activity and severity in lupus

Abstract

Systemic lupus erythematosus (SLE) is a relatively uncommon Background: disease of young females in Pakistan. Usually, it has a relapsing-remitting course with variable severity and disease activity. Amongst the different clinical and laboratory parameters used to monitor disease activity in lupus, mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan.The aim of this study Methods: was to evaluate the role of MPV as a biomarker of disease activity in SLE. This study included 25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLE disease activity index (SLEDAI) and erythrocyte sedimentation rate (ESR). Independent sample t-test and Pearson's correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis.The MPV of patients with active Results: SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( <0.001). MPV had an inverse relationship with both ESR (r=-0.93, P <0.001) and SLEDAI (r= -0.94, <0.001). However, there was a strong P P positive correlation between ESR and SLEDAI (r=0.95, <0.001). For MPV, a P cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( < 0.001).Higher disease activity in SLE is associated with a P Conclusions: correspondingly low MPV.

Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

“…Other studies have found results similar to ours [ 13 , 15 , 19 ]. In rheumatoid arthritis, there is a study that also demonstrated diminished results of MPV in the active disease.…”

“…Although our MPV results did not show statistically significant correlation with the parameters of CRP, ESR and C3 and C4 complement components, we found a negative correlation between MPV and SLEDAI, similar to that found by Khan A., et al [ 19 ]. Although the correlation was weak, it confirms that the diminished results of MPV in patients with active SLE are linked to the disease activity.…”

“…This index has been shown to be associated with the inflammatory process, and it is also an important marker of platelet activation and function [ 5 , 6 , 13 - 18 ]. Several studies suggest that MPV may be a good marker of disease activity in SLE, presenting low cost and wide availability [ 5 , 13 , 15 , 19 ]. Recent studies have found that MPV significantly reduced in patients with active disease [ 15 , 19 ], including negative correlation with SLEDAI [ 19 ].…”

“…Several studies suggest that MPV may be a good marker of disease activity in SLE, presenting low cost and wide availability [ 5 , 13 , 15 , 19 ]. Recent studies have found that MPV significantly reduced in patients with active disease [ 15 , 19 ], including negative correlation with SLEDAI [ 19 ]. Other study performed in a juvenile SLE (JSLE) population, however, showed significantly higher MPV values in patients compared to healthy controls and in the active disease group when compared to the remission group.…”

Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus

“…SLEDAI, systemic lupus erythematosus disease activity index; MPV, mean platelet volume; ESR, erythrocyte sedimentation rate; WBC, white blood cell (thousand/mm 3 ); Hb, hemoglobin (gm/dl); platelets, platelet count × 10 3 . doi, 10.5256/f1000research.10763.d151064 29 …”