Monitoring for neurotoxic effects from low level exposures to organophosphate pesticides

Richter, Elihu D.; Kaspi, L.; Gordon, Margaret Jane; Levy, Sara; Israeli, Raphael; Gruener, Nachman

doi:10.1016/0048-9697(84)90157-8

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…Although the determination of AChE activity as a measure of exposure to OPs and carbamates is rapid, inexpensive, and convenient, this method lacks sensitivity and specificity at low levels of exposure [22,23]. As such, this method is useful for the diagnosis of acute poisoning, but it may be an unreliable indicator of low level exposure [24]. The major pesticide used in this study was insecticides (84.6 %), followed by herbicides, fungicides, and acaricides (63.2, 7.1, 6.6 %, respectively).…”

Section: Discussionmentioning

confidence: 99%

Health symptoms related to pesticide exposure and agricultural tasks among rice farmers from northern Thailand

Sapbamrer

Nata²

2013

Environ Health Prev Med

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Purpose The objective of this cross-sectional study was to investigate health symptoms related to occupational pesticide exposure and agricultural tasks in rice farmers. Methods Data on demographic variables and health symptoms associated with pesticide exposure were collected from 182 rice farmers (exposed subjects) and 122 non-farmers (controlled group) using interviews and measuring whole blood acetylcholinesterase (AChE) activity during August and October 2012. Results Rice farmers had a significantly lower median AChE activity than the controls (9,594 vs. 10,530 U/L, respectively) and a significantly higher prevalence of difficulty in breathing and chest pain [odds ratio (OR) 2.8, P \ 0.01 and OR 2.5, P \ 0.05, respectively]. The prevalence of dry throat and cramp was associated with those farmers who sprayed and mixed pesticides (OR 2.5 and 2.6 for dry throat, OR 2.5 and 2.9 for cramp, respectively; P \ 0.01). The prevalence of numbness and diarrhea was associated with those farmers who scattered seed (OR 2.2, P \ 0.01 and OR 3.6, P \ 0.05, respectively). The prevalence of numbness and increasing anxiety was also associated with those farmers who harvested crops (OR 3.6, P \ 0.01 and OR 3.0, P \ 0.05, respectively). Conclusions Our findings suggest that occupational pesticide exposure and agricultural tasks in the paddy field may be associated with the increasing prevalence of respiratory tract and muscle symptoms. This possibility warrants further investigation in more detail.

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Section: Discussionmentioning

confidence: 99%

Health symptoms related to pesticide exposure and agricultural tasks among rice farmers from northern Thailand

Sapbamrer

Nata²

2013

Environ Health Prev Med

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“…In the 1980s, we carried out studies on the neurobehavioral effects associated with low level exposure to OP pesticides from drift in orchard workers and residents in kibbutzim of the Hula Valley (Richter et al, 1984(Richter et al, , 1986. These studies demonstrated dose-response gradients linking everyday symptoms of illness with measured levels of OP metabolites in residents and workers.…”

Section: Studies On Neurotoxic Effects Of Low Level Long-term Exposumentioning

confidence: 99%

“…The consequence of short-term exposures to OPS on neurotoxic outcomes has been reviewed (Richter, 1987(Richter, , 1993Richter et al, 1984Richter et al, , 1986. Major findings from these studies attest to OP effects on clinical parameters and neurobehavioral tests, both in occupational and community sentinel groups in Israel.…”

Section: Studies On Low Level Exposure To Ops and The Short-term Neurmentioning

confidence: 99%

Epidemiological Studies of Anticholinesterase Pesticide Poisoning in Israel

Finkelstein

Richiter

Aschner

2011

Anticholinesterase Pesticides

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“…B. [23,96]). Der experimentelle Beweis für einen solchen Effekt steht in der Neurotoxikologie,vor allem für toxische PS, bisher aber aus.…”

Section: Fall-kontroll-und Kohortenstudien Mit Pestizidexponierten -Uunclassified

Pestizidexposition und Parkinson-Syndrom

Vieregge

2002

Der Nervenarzt

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Retrospective case-control studies among patients with idiopathic Parkinson's syndrome (IPS) show a positive association to the existence of a - mostly premorbid - exposure to pesticides. In acute pesticide intoxications, usually symptoms other than parkinsonism are found. Therefore, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) continues to be the agent best documented both experimentally and clinically to cause a clinical syndrome comparable to IPS. It is debated whether still unknown effects between exogenous pesticide exposure and the xenobiotic enzyme system may lead to IPS in single genetically susceptible individuals. In practice, the present data on the problem of pesticide exposure in IPS are irrelevant for medicolegal considerations.

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Monitoring for neurotoxic effects from low level exposures to organophosphate pesticides

Cited by 9 publications

References 6 publications

Health symptoms related to pesticide exposure and agricultural tasks among rice farmers from northern Thailand

Health symptoms related to pesticide exposure and agricultural tasks among rice farmers from northern Thailand

Epidemiological Studies of Anticholinesterase Pesticide Poisoning in Israel

Pestizidexposition und Parkinson-Syndrom

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