Monitoring lidocaine single‐crystal dissolution by ultraviolet imaging

A method for phenomenological and chemical kinetics study of autocatalytic reactive dissolution by optical microscopy. The case of uranium dioxide dissolution in nitric acid media

“…Steiger et al used it for general observation of the growth and dissolution of lithium mosses and needles in 1 mol l À1 LiPF 6 [8] and during lithium electrodeposition on tungsten and copper substrates [9]. Boetker et al [15] studied the concentration gradients and diffusion layer thickness around amlodipine besylate dissolving in water, as well as Østergaard et al [16] for lidocaine dissolution in water and Delwaulle et al [17,18] for copper and uranium dioxide dissolving in nitric acid. Mgaidi et al [4] and Singh et al [19] used it for monitoring the evolution of the morphology of sand and succinic acid crystals during dissolution.…”

Influence of Sodium Lauryl Sulfate and Tween 80 on Carbamazepine–Nicotinamide Cocrystal Solubility and Dissolution Behaviour

“…Therefore, IDR is independent of formulation effects and measures the intrinsic properties of the drug as a function of dissolution media, e.g., pH, ionic strength and counter-ions. Recently, UV imaging has shown great promise in understanding the dissolution behaviour of drug compounds because, when combined with a channel flow cell method, it can visualise the solution concentration distribution during dissolution in real time, providing a platform for generating spatial and temporal information about the dissolved solution phase of a solid drug during dissolution [8,21,22]. …”

Real-time UV imaging identifies the role of pH in insulin dissolution behavior in hydrogel-based subcutaneous tissue surrogate

“…From the obtained UV absorbance maps it can be seen that the dissolution cell, with time, appears to be filled from the bottom and up. UV imaging is capable of visualizing different mass transport phenomena and the above mentioned observations are most likely due to the formation of a density gradient as observed previously for other systems (Gaunø et al, 2013;Østergaard et al, 2011). The density gradient made these experiments unsuitable for quantification of the dissolution rate, because the dissolved drug compound escaped the UV imaging area after e.g.…”

“…A closer look into dissolution and release processes may be obtained by different imaging techniques including, magnetic resonance imaging (MRI) (Fyfe and Blazek-Welsh, 2000;Nott, 2010;Richardson et al, 2005), Fourier transform infrared (FTIR) imaging (Kazarian and van der Weerd, 2008;Kazarian and Ewing, 2013;Kimber et al, 2011), fluorescence imaging (Adler et al, 1999;Bajwa et al, 2006;Brandl et al, 2010), and UV imaging (Boetker et al, 2011;Østergaard et al, 2011). UV imaging provides the ability to generate temporally and spatially resolved data in the form of images from the absorbance of UV light (Østergaard et al, 2010).…”