Monitoring Neurocognitive Functioning After Pediatric Cellular Therapy or Hematopoietic Cell Transplant: Guidelines From the COG Neurocognition in Cellular Therapies Task Force

Schofield, Hannah-Lise T.; Fabrizio, Vanessa A; Braniecki, Suzanne; Pelletier, Wendy; Eissa, Hesham; Murphy, Beverly; Chewning, Joseph H.; Barton, Karen D.; Embry, Leanne; Levine, John E.; Schultz, Kirk R.; Page, Kristin

doi:10.1016/j.jtct.2022.06.027

Cited by 6 publications

(18 citation statements)

References 110 publications

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“…Four impairment‐specific guidelines were identified: two addressed fatigue, 49,50 one addressed neurocognitive function, 56 and one addressed chronic pain 41 (Table 3). Fatigue guidelines provided many recommendations for interventions focusing on physical activity, energy‐conservation and adaptive strategies, sleep hygiene, mindfulness/relaxation, psychological support, and cognitive‐behavioral therapy 49,50 .…”

Section: Resultsmentioning

confidence: 99%

“…Identify patients in greatest need of neurocognitive assessment: Treatment history indicating risk for cognitive late effects, including those with CNS pathology, CNS radiation therapy or total brain irradiation, history of HCT (with or without GVHD); special focus on those who experience cytokine release syndrome or immune effector cell‐associated neurotoxicity syndrome and children younger than 6 years at the time of treatment (Schofield 2022 56 )…”

Section: Resultsmentioning

confidence: 99%

“…Testing should focus on cognitive domains potentially at risk because of HSCT, CAR‐T–cell therapy, and other immunotherapies (Schofield 2022 56 )…”

Section: Resultsmentioning

confidence: 99%

“…Nine guidelines and two expert consensus reports provided recommendations for ontreatment and off-treatment phases 39,[42][43][44][45][46][47][48][49][50][51] ; five guidelines and two expert consensus reports addressed the off-treatment phase only [34][35][36]40,[52][53][54] ; one expert consensus provided recommendations for the on-treatment phase only 55 ; four guidelines and five expert consensuses provided rehabilitation recommendations for children with cancer but did not clearly specify the timing/phase of treatment. 37,38,41,[56][57][58][59][60][61]…”

Section: F I G U R E 1 Preferred Reporting Items For Systematic Revie...mentioning

confidence: 99%

“…The neurocognitive function guideline provided numerous recommendations related to neurocognitive evaluation, including domains to assess and timing of testing. 56 One intervention was recommended for neurocognition-targeted strategies, such as educational accommodations. 56 The guideline addressing chronic pain management 41 was developed by the World Health Organization and is not specific to individuals with cancer, but this guideline is endorsed by the Children's Oncology Group (COG) and thus was included in this synthesis.…”

Section: Impairment-specific Recommendationsmentioning

confidence: 99%

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Clinical practice guideline and expert consensus recommendations for rehabilitation among children with cancer: A systematic review

L’Hotta

Randolph²,

Reader

et al. 2023

CA A Cancer J Clinicians

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Increased attention to the rehabilitation needs of children with cancer is vital to enhance health, quality‐of‐life, and productivity outcomes. Among adults with cancer, rehabilitation recommendations are frequently incorporated into guidelines, but the extent to which recommendations exist for children is unknown. Reports included in this systematic review are guideline or expert consensus reports containing recommendations related to rehabilitation referral, evaluation, and/or intervention for individuals diagnosed with cancer during childhood (younger than 18 years). Eligible reports were published in English from January 2000 to August 2022. Through database searches, 42,982 records were identified; 62 records were identified through citation and website searching. Twenty‐eight reports were included in the review: 18 guidelines and 10 expert consensus reports. Rehabilitation recommendations were identified in disease‐specific (e.g., acute lymphoblastic leukemia), impairment‐specific (e.g., fatigue, neurocognition, pain), adolescent and young adult, and long‐term follow‐up reports. Example recommendations included physical activity and energy‐conservation techniques to address fatigue, referral to physical therapy for chronic pain management, ongoing psychosocial surveillance, and referral to speech‐language pathology for those with hearing loss. High‐level evidence supported rehabilitation recommendations for long‐term follow‐up care, fatigue, and psychosocial/mental health screening. Few intervention recommendations were included in guideline and consensus reports. In this developing field, it is critical to include pediatric oncology rehabilitation providers in guideline and consensus development initiatives. This review enhances the availability and clarity of rehabilitation‐relevant guidelines that can help prevent and mitigate cancer‐related disability among children by supporting access to rehabilitation services.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Testing should focus on cognitive domains potentially at risk because of HSCT, CAR‐T–cell therapy, and other immunotherapies (Schofield 2022 56 )…”

Section: Resultsmentioning

confidence: 99%

Section: F I G U R E 1 Preferred Reporting Items For Systematic Revie...mentioning

confidence: 99%

Section: Impairment-specific Recommendationsmentioning

confidence: 99%

See 3 more Smart Citations

Clinical practice guideline and expert consensus recommendations for rehabilitation among children with cancer: A systematic review

L’Hotta

Randolph²,

Reader

et al. 2023

CA A Cancer J Clinicians

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Children's Oncology Group's 2023 blueprint for research: Cellular therapy and stem cell transplantation

Kitko

Bollard

Cairo

et al. 2023

Pediatric Blood & Cancer

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Since the publication of the last Cellular Therapy and Stem Cell Transplant blueprint in 2013, Children's Oncology Group cellular therapy‐based trials advanced the field and created new standards of care across a wide spectrum of pediatric cancer diagnoses. Key findings include that tandem autologous transplant improved survival for patients with neuroblastoma and atypical teratoid/rhabdoid brain tumors, one umbilical cord blood (UCB) donor was safer than two UCB donors, killer immunoglobulin receptor (KIR) mismatched donors did not improve survival for pediatric acute myeloid leukemia when in vivo T‐cell depletion is used, and the depth of remission as measured by next‐generation sequencing‐based minimal residual disease assessment pretransplant was the best predictor of relapse for acute lymphoblastic leukemia. Plans for the next decade include optimizing donor selection for transplants for acute leukemia/myelodysplastic syndrome, using novel engineered cellular therapies to target a wide array of malignancies, and developing better treatments for cellular therapy toxicities such as viral infections and graft‐vs‐host disease.

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International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update

Rotz,

Bhatt,

Hamilton

et al. 2024

Transplantation and Cellular Therapy

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Monitoring Neurocognitive Functioning After Pediatric Cellular Therapy or Hematopoietic Cell Transplant: Guidelines From the COG Neurocognition in Cellular Therapies Task Force

Cited by 6 publications

References 110 publications

Clinical practice guideline and expert consensus recommendations for rehabilitation among children with cancer: A systematic review

Clinical practice guideline and expert consensus recommendations for rehabilitation among children with cancer: A systematic review

Children's Oncology Group's 2023 blueprint for research: Cellular therapy and stem cell transplantation

International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update

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