Monkeypox and fecal microbiota for transplantation(FMT): An unprecedented risk?

Contextualization: Since May 2022, cases of monkeypox (mpox) have been reported in several countries, with evidence of community transmission. In the current scenario, transmission has been identified in different continents, related to the local spread of the virus by intimate inter-human contact. Objective: The purpose of this article is to inform the transplant community about the possible implications of the disease for the population of transplant recipients and their donors. Method: This article presents guidelines for adapting the evaluation of donors and candidates for organ transplants, bearing in mind the potential risks resulting from the emergence of mpox in our midst. It is important to consider that this document reflects the opinion of specialists given the scarce evidence currently available. Results and Conclusions: Donor assessment and management recommendations are based on the potential risk of monkeypox vírus (MPXV ) transmission. The risk of transmission by transplantation is estimated to be low, taking into account the uncertainty about the duration of viremia in patients with mpox and the presence of viable virus in cells and tissues. It is recommended, however, that the physicians responsible for the patient are alert to evidence of infection and that they activate or notify the institutions in case there are indications of transmission through the transplant.

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“…Porém, os questionários de sinais e sintomas precisam ser realizados de forma rigorosa, evitando eventos adversos. [11][12][13]…”

Section: Etiologia E Epidemiologiaunclassified

Monkeypox Virus Infection: Donor and Candidate Evaluation for Solid Organ Transplantation

Clemente

Stucchi

Santos

et al. 2023

BJT

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Mpox: What Practicing Gastroenterologists Need to Know

2023

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A systematic review on environmental perspectives of monkeypox virus

Hemati

Mohammadi‐Moghadam

2023

Reviews on Environmental Health

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Monkeypox (MPX) is one of the common infections between humans and animals that caused by a virus belonging to the Orthopoxvirus genus. The Monkeypox virus (MPXV) outbreak is a global crisis triggered by environmental factors (virus, wastewater, surface, air) and amplified by the decisions of government officials and communities. The aim of this systematic review is to describe the environmental perspectives of MPXV with emphasis on risk assessment to prevent and control a new pandemic. Five online databases including Web of Science, PubMed, Scopus, Science Direct and Google Scholar were searched from 1990 to October 2022. Among 120 records, after the screening, four studies were included in the systematic review. The systematic review revealed that the possibility of MPXV transmission through wastewater, air, and the contaminated surfaces is a significant concern and its detection and destroying will play a major role in controlling the spread of the virus. Poxviruses have a high environmental stability, but are sensitive to all common chemical disinfectants. In conclusion, this study revealed that the environmental surveillance can be used as a complementary tool for detecting pathogens circulation in communities. This implies that the monitoring of environmental perspectives of MPXV can provide new awareness into virus transmission routes as well as the role of stakeholders and public health policies in MPXV risk management.

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Monkeypox and fecal microbiota for transplantation(FMT): An unprecedented risk?

Cited by 3 publications

References 8 publications

Monkeypox Virus Infection: Donor and Candidate Evaluation for Solid Organ Transplantation

Monkeypox Virus Infection: Donor and Candidate Evaluation for Solid Organ Transplantation

Mpox: What Practicing Gastroenterologists Need to Know

A systematic review on environmental perspectives of monkeypox virus

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