Monochorionic diamniotic in vitro fertilization twins have a decreased incidence of twin-to-twin transfusion syndrome

Ben‐Ami, Ido; Molina, Francisca S.; Battino, Shlomo; Daniel-Spiegel, Etty; Melcer, Yaakov; Flöck, A; Geipel, A.; Odeh, Marwan; Miron, Pierre; Maymon, Ron

doi:10.1016/j.fertnstert.2015.11.036

Cited by 13 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recipient twin develops cardiomyopathy and abnormal diastolic and systolic function [70][71][72][73] . Interestingly, MCDA twins conceived after eSET splitting may experience less TTTS [74] . This suggests a potential different embryological process inherent to ART-conceived monozygotic twinning.…”

Section: Morbiditymentioning

confidence: 99%

Re-Thinking Elective Single Embryo Transfer: Increased Risk of Monochorionic Twinning - A Systematic Review

Dziadosz

Evans²

2017

Fetal Diagn Ther

View full text Add to dashboard Cite

Background/Objectives: Multiple pregnancies have tripled in the United States over the past 3 decades. Attributed to increasing maternal age at delivery but more so assisted reproductive technological advances, an effort has been made to decrease twinning through elective single embryo transfer. We sought to review and evaluate risks of monochorionic twinning as a predictable consequence of increasing utilization of elective single embryo transfer on perinatal outcomes. Primary outcomes included twinning rates, fetal anomalies, growth, preterm birth, and mortality. Secondary outcomes included neurological and pulmonary disability, intrauterine growth restriction, and congenital cardiac anomalies and twin-twin transfusion syndrome. Data sources: PubMed and Embase. Results: A total of 106 studies identified by systematic search met the inclusion criteria. The trend for lower numbers of embryos transferred has inadvertently led to an increase in monochorionic twinning. This is associated with worse outcomes compared to dichorionic twinning and singleton gestations for all outcomes studied. Discussion: Of great concern for monochorionic twins is the risk profile of significant morbidity and mortality. Transfer of 2 embryos should be considered to avoid higher risks inherent to the shared placental phenomena related to monochorionic twins.

show abstract

Section: Morbiditymentioning

confidence: 99%

Re-Thinking Elective Single Embryo Transfer: Increased Risk of Monochorionic Twinning - A Systematic Review

Dziadosz

Evans²

2017

Fetal Diagn Ther

View full text Add to dashboard Cite

show abstract

“…This in agreement with the results of earlier studies 13,14,16,28 . One study even reported a lower incidence of TTTS in MCDA pregnancies conceived after IVF 37 , but the authors excluded pregnancies that resulted in the loss of one or both twins, which is often the result of TTTS.…”

Section: Discussionmentioning

confidence: 99%

Monochorionic twins after in‐vitro fertilization: do they have poorer outcomes?

Couck

Nylen

Deprest

et al. 2020

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

Objective To compare the outcome of monochorionic diamniotic (MCDA) twin pregnancies conceived by in‐vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with that of spontaneously conceived MCDA twins. Methods This was a retrospective cohort study of MCDA twin pregnancies conceived after IVF/ICSI or spontaneously, followed from the first trimester onwards at a single center between January 2002 and September 2018. The primary outcome was survival per fetus from the first trimester until 28 days after birth. Secondary outcome measures were number of survivors, miscarriage, termination of pregnancy, intrauterine and neonatal death, major congenital anomalies, twin–twin transfusion syndrome, selective fetal growth restriction, gestational age at birth, delivery before 32 weeks' gestation, mode of delivery, admission to the neonatal intensive care unit, birth weight and birth‐weight discordance. Results Of the 654 MCDA pregnancies included in the analysis, 80 were conceived by IVF/ICSI and 574 spontaneously. Overall fetal and neonatal survival was significantly lower in the IVF/ICSI group than in the spontaneous‐conception group (79% vs 90%; P = 0.001). In the IVF/ICSI group, compared with the spontaneous‐conception group, loss of one or both twins occurred twice as often (29% vs 14%; P = 0.001) and there was a higher risk of second‐trimester miscarriage (8% vs 1%; P = 0.002). Conclusions MCDA twins conceived after IVF/ICSI have lower overall survival rates and higher rates of second‐trimester miscarriage than do spontaneously conceived MCDA twins. Copyright © 2020 ISUOG. Published by John Wiley & Sons Ltd.

show abstract

“…Prof. Kagan conducted studies to identify twin related structural and chromosomal complications [10] and described new methods that have been adopted by many in the world. He and his team have pointed out to the impact of chorionicity and maternal serum markers on Down Syndrome screening in twin pregnancies in the 1 st trimester and identified the discordance in nuchal translucency thickness in the prediction of severe TTTS [31]. Prof. Burrell in Spain also identified many genetic complications in twin pregnancies.…”

Section: Develop a Differential Diagnosis And Predic-mentioning

confidence: 99%

Pre-Twin Screen - A Multi-Disciplinary Approach for a Personalized Prenatal Diagnostics and Care for Twin Pregnancies

Meiri¹,

Kugler²,

Svirsky³

et al. 2020

Int J Women's Health Wellness

View full text Add to dashboard Cite

The prevalence of twin pregnancies is rising globally due to increased assisted conception and advanced maternal age in pregnancy. Twin pregnancies have 5-9 times higher frequencies of fetal chromosomal and structural abnormalities, often deliver preterm, and have high prevalence of gestational diabetes mellitus (GDM), preeclampsia (PE), and intrauterine growth restriction (IUGR) compared to singletons. Twins have special complications such as twins-to twin transfusion syndrome in mono chorionic (MC) twins. Consequently, more twins are born prematurely, suffer from low birth weight, cerebral palsy, etc., often requiring admission to newborn intensive care units, and develop motor and cognitive disorders for life. These impose a huge burden on individuals, families, and the society.

show abstract

Monochorionic diamniotic in vitro fertilization twins have a decreased incidence of twin-to-twin transfusion syndrome

Abstract: The significantly lower proportion of TTTS found in IVF-conceived twins may suggest a different embryological process that lies at the core of IVF conception of monozygotic twinning.

Cited by 13 publications

References 24 publications

Re-Thinking Elective Single Embryo Transfer: Increased Risk of Monochorionic Twinning - A Systematic Review

Re-Thinking Elective Single Embryo Transfer: Increased Risk of Monochorionic Twinning - A Systematic Review

Monochorionic twins after in‐vitro fertilization: do they have poorer outcomes?

Pre-Twin Screen - A Multi-Disciplinary Approach for a Personalized Prenatal Diagnostics and Care for Twin Pregnancies

Contact Info

Product

Resources

About