Monochromatic X-rays for Low-Dose Digital Mammography

Yoon, Kwon‐Ha; Kwon, Young Hoo; Choi, Byoungjung; Son, Hyun Hwa; Ryu, Cheol Woo; Chon, Kwon Su; Park, Seong Hoon; Juhng, Sun Kwan

doi:10.1097/rli.0b013e31826badfb

Cited by 12 publications

(11 citation statements)

References 14 publications

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“…Differential phase contrast mammography may have the potential to advance as a new diagnostic tool and eventually outperform recently introduced approaches, for instance, the use of monochromatic x-rays for digital mammography. 32 So far, no other imaging technology is capable of exploiting x-ray differential phase and scattering signals to significantly improve soft tissue imaging. These results are promising toward the use of phase contrast grating interferometry in vivo in a clinical setting.…”

Section: Study Limitationsmentioning

confidence: 99%

A Study on Mastectomy Samples to Evaluate Breast Imaging Quality and Potential Clinical Relevance of Differential Phase Contrast Mammography

Hauser¹,

Wang²,

Ra³

et al. 2014

Investigative Radiology

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Section: Study Limitationsmentioning

confidence: 99%

A Study on Mastectomy Samples to Evaluate Breast Imaging Quality and Potential Clinical Relevance of Differential Phase Contrast Mammography

Hauser¹,

Wang²,

Ra³

et al. 2014

Investigative Radiology

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“…2 In breast cancer diagnostics, mammography is the most frequently used imaging modality. 3,4 Diagnostic performance of mammography is good but depends heavily on breast density. 5 Since the introduction of full-field digital mammography (FFDM), new techniques were developed to further improve mammography's diagnostic performance, such as contrast-enhanced spectral mammography (CESM).…”

mentioning

confidence: 99%

Radiation Exposure of Contrast-Enhanced Spectral Mammography Compared With Full-Field Digital Mammography

Jeukens¹,

Lalji²,

Meijer³

et al. 2014

Investigative Radiology

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“…In particular, narrow band emission centered at 21.5 keV showed a 12‐fold reduction in dose on a 4.5 cm thick breast phantom compared to that obtained using a tungsten‐based x‐ray tube while achieving 1.85 times improvement in the SNR. The system used for the latter experiments also demonstrated a spatial resolution of 7 lp/mm as defined by the 10% level of its measured MTF 17 …”

Section: Introductionmentioning

confidence: 99%

“…Higher throughput monochromators using multilayer structures instead of conventional Bragg crystals offer possibilities of monochromatic imaging using conventional broadband x‐ray sources instead of synchrotrons. Measurements with multilayers that produce monochromatic lines at 18 and 21.5 keV are described in the literature 17,18 . In particular, narrow band emission centered at 21.5 keV showed a 12‐fold reduction in dose on a 4.5 cm thick breast phantom compared to that obtained using a tungsten‐based x‐ray tube while achieving 1.85 times improvement in the SNR.…”

Section: Introductionmentioning

confidence: 99%

Innovative monochromatic x‐ray source for high‐quality and low‐dose medical imaging

Shulman¹,

Rehani

2021

Medical Physics

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Purpose An estimated 377 million diagnostic and interventional radiological exams are performed annually in the United States and approximately 4 to 5 billion globally. All use x‐ray tubes that emit x‐rays over a broad energy band, a technology that is more than a century old. Only a small fraction of the radiation is useful for imaging while the remaining fraction either increases the radiation dose received by the patient or degrades the image. Monochromatic x‐rays can provide lower dose images in many of these radiological applications while maintaining or improving image quality. We report the development of the first monochromatic x‐ray source suitable for low‐dose, high‐quality imaging in the clinic and demonstrate its first application and performance with mammography phantoms. Methods X‐ray fluorescence was used to generate monochromatic x‐rays with selectable energies from 18 to 60 keV. This patented technology was incorporated into a laboratory prototype of a monochromatic x‐ray mammography system. Image quality was evaluated as a function of radiation dose in standard breast phantoms using the signal‐to‐noise ratio (SNR) measured for high and low contrast masses and microcalcifications. Spatial imaging properties were assessed from these images as well as from modulation transfer function (MTF) analysis. Measurements using an iodine contrast agent were also performed. The results were compared to those obtained using a commercially available, conventional x‐ray mammography system. Results Our prototype system reduced radiation dose by factors of five to ten times for the same SNRs as obtained from the conventional system. This performance was demonstrated in phantoms simulating a wide range of lesion sizes and microcalcifications in a variety of breast thicknesses. The high SNRs for very thick breast phantoms provide evidence that screening with less breast compression is possible while maintaining image quality. Contrast‐enhanced digital mammography (CEDM) with monochromatic x‐rays was shown to provide a simpler and more effective technique at substantially lower radiation dose. The MTF value at 20% was 9 lp/mm. Conclusions The monochromatic x‐ray system is more sensitive for imaging a wide range of breast sizes and compositions than conventional broadband mammography. High image quality and lower dose are its hallmarks. It also makes CEDM much more effective than current methods developed for use with conventional broadband mammography systems.

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Monochromatic X-rays for Low-Dose Digital Mammography

Abstract: Monochromatic x-rays generated using a multilayer mirror may be a useful diagnostic tool for breast examination by providing high contrast imaging with a low radiation dose.

Cited by 12 publications

References 14 publications

A Study on Mastectomy Samples to Evaluate Breast Imaging Quality and Potential Clinical Relevance of Differential Phase Contrast Mammography

A Study on Mastectomy Samples to Evaluate Breast Imaging Quality and Potential Clinical Relevance of Differential Phase Contrast Mammography

Radiation Exposure of Contrast-Enhanced Spectral Mammography Compared With Full-Field Digital Mammography

Innovative monochromatic x‐ray source for high‐quality and low‐dose medical imaging

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