1983
DOI: 10.1073/pnas.80.22.6863
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Monoclonal antibodies that prevent adhesion of B 16 melanoma cells and reduce metastases in mice: crossreaction with human tumor cells.

Abstract: Monoclonal antibodies raised against B 16 melanoma cells in syngeneic mice were functionally screened for their ability to inhibit cell adhesion in tissue culture. Three of these antibodies (16/43, 16/77, 16/82), when preinjected into C57BL/6 mice, markedly reduced the number of experimental lung metastases produced by B 16 cells, possibly by interference with their adhesion to the lung endothelia. We now report that these monoclonal antibodies block in vitro attachment of the majority of human melanoma cell l… Show more

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Cited by 39 publications
(14 citation statements)
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“…It has been shown that the cell and matrix interactions promote cell migration, proliferation, and ECM degradation (27) while inhibitory agents for cell adhesion may reduce the invasiveness and metastatic potential of tumor cells (28). Furthermore, the interactions between cells with ECM, which promote adhesion and migration, are believed to be essential for invasion, migration, and metastasis of tumors (29).…”
Section: Discussionmentioning
confidence: 99%
“…It has been shown that the cell and matrix interactions promote cell migration, proliferation, and ECM degradation (27) while inhibitory agents for cell adhesion may reduce the invasiveness and metastatic potential of tumor cells (28). Furthermore, the interactions between cells with ECM, which promote adhesion and migration, are believed to be essential for invasion, migration, and metastasis of tumors (29).…”
Section: Discussionmentioning
confidence: 99%
“…The attachment of cells to plastic has important correlations in vivo, as monoclonal antibodies whichi inhibit attachment in vitro can also reduce lung colonization (Vollmers & Birchmeier, 1983). However, attachment to a more natural substrate such as endothelial cells or ECM would be a better in vitro model (Varani et al, 1983).…”
Section: Aggregation and Disaggregation The Results Inmentioning
confidence: 99%
“…Observation and measurement of adhesion and motility in vivo have inherent difficulties, but these characters can be investigated in vitro and some clues about their possible significance in vivo thereby gained (Briles & Kornfeld, 1978;Hart, 1979;Vollmers & Birchmeier, 1983;McCarthy et al, 1985).…”
mentioning
confidence: 99%
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“…The parallels between tumor cell development and embryogenesis have been discussed frequently (e.g., refs. 42 and 43), but they take on special significance as we begin to identify the specific cell surface molecules that mediate adhesion (44)(45)(46)(47)(48)(49). While there are certainly many other factors that influence tumor cell-host interactions (cf.…”
Section: Discussionmentioning
confidence: 99%