Monoclonal Gammopathy of Undetermined Significance and Russell Body Formation in <i>Helicobacter pylori</i> Gastritis

Wolkersdörfer, Gernot W.; Haase, Michael; Morgner, Andrea; Baretton, Gustavo; Miehlke, Stephan

doi:10.1111/j.1523-5378.2006.00443.x

Cited by 36 publications

(38 citation statements)

References 30 publications

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“…Resolution of the gammopathy is observed in up to 30% of cases by eradicating the bacteria [257], a relationship confirmed by some authors [246,258] but not by others [215,259].…”

Section: Plasma Cell Dyscrasiasmentioning

confidence: 81%

Helicobacter pylori and Hematologic Diseases

Campuzano-Maya¹

2016

Extradigestive Manifestations of Helicobacter Pylori Infection - An Overview

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Helicobacter pylori infection is the most common infection of the human species, with developing countries displaying a marked disadvantage in contrast to developing countries. While H. pylori infection is asymptomatic in most infected individuals, it is intimately related to malignant diseases of the stomach, such as gastric cancer and gastric MALT lymphoma, as well as benign diseases, for example chronic gastritis and duodenal and gastric peptic ulcers. Since the discovery that gastric mucosa could be colonized by bacteria, evidence of greater than 50 extragastric manifestations has been reported, linking H. pylori infection and the development of diseases associated with cardiology, dermatology, endocrinology, obstetrics and gynecology, hematology, pneumology, neurology, odontology, ophthalmology, otorhinolaryngology, and pediatrics. This chapter presents the extragastric manifestations of H. pylori infection expressed through hematologic diseases; particularly those included in the international consensus, and discusses guidelines for the management of H. pylori infection, such as iron deficiency, vitamin B 12 (cobalamin) deficiency, and immune thrombocytopenia. Other manifestations reviewed include immune neutropenia, antiphospholipid syndrome, and plasma cell dyscrasias, such us monoclonal gammopathy of undetermined significance, multiple myeloma, and Henoch-Schönlein purpura.

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“…Resolution of the gammopathy is observed in up to 30% of cases by eradicating the bacteria [257], a relationship confirmed by some authors [246,258] but not by others [215,259].…”

Section: Plasma Cell Dyscrasiasmentioning

confidence: 81%

Helicobacter pylori and Hematologic Diseases

Campuzano-Maya¹

2016

Extradigestive Manifestations of Helicobacter Pylori Infection - An Overview

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“…In Russell body cervicitis, the plasma cells are filled with Russell bodies. This condition has also been reported in chronic inflammatory reactions due to its long-term antigenic stimulations, much as in chronic lymphocytic thyroiditis, rheumatoid arthritis, and ulcerative colitis, as well as in neoplastic processes like plasmacytoma and B-cell lymphomas [7][8].…”

Section: Introductionmentioning

confidence: 88%

“…Russell body cells have been reported to rarely accompany ophthalmitis, esophagitis, gingivitis, gastritis, cervicitis, dermatitis, duodenum ulcers [10][11][12][13][14][15][16][17][18][19][20]. We know of only a few studies that have reported that Russell body cells can occur in cervicitis.…”

Section: Introductionmentioning

confidence: 99%

Russell body cervicitis: A case report and literature review

Altun¹,

Turhan²,

Taşkın³

2017

Med-Science

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Russell bodies are prominent eosinophilic inclusions seen in the cytoplasm of plasma cells and sometimes outside the cell. There are very few publications available in the English literature on Russell Body Cervicitis. Our case is a 40 year old female patient with a positive screening test for HPV DNA. The cervical surface epithelium in biopsy specimens obtained from the cervix completely have eroded intense vesicular eccentric nuclei and large eosinophilic cytoplasm containing focal Russell Body. The infiltration of dense plasma cells were observed. Our case is the fourth case in the English literature. The case is rare and the etiology has not yet been elucidated.

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“…As the incidence of these lesions is low relative to H. pylori –associated gastritis, the contribution of H. pylori infection to their development is questionable. Furthermore, careful evaluation of their underlying cause is essential, as they can be associated with monoclonal gammopathy or lymphoreticular neoplasms [20,43,48]. The possible connections between H. pylori infection and these immunoglobulin accumulations, diagnostically relevant histological features, and biological significance are described below.…”

Section: Intracellular Immunoglobulin Accumulation In Association Witmentioning

confidence: 99%

“…Interestingly, light chain restriction was detected via immunohistochemistry in 12 out of 30 cases of RBG (kappa restriction in 11 cases and lambda restriction in one case) [9,20,48,58,61]. Ten of these cases were localized gastric lesions with no associated lymphoid malignancy or plasma cell disorder, although one case was associated with low-grade MALT lymphoma [48], and another with concomitant monoclonal gammopathy of undetermined significance [20]. This could be explained by the findings of Girón and Shah [63], who reported that approximately 50% of patients with H. pylori infection exhibit either kappa or lambda light chain elevation, and suggested that H. pylori infection might contribute to immunoglobulin light chain dysfunction.…”

Section: Intracellular Immunoglobulin Accumulation In Association Witmentioning

confidence: 99%

Rare Gastric Lesions Associated with Helicobacter pylori Infection: A Histopathological Review

Joo¹

2017

J Pathol Transl Med

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Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. However, some rare gastric lesions exhibiting distinctive histological features may also be associated with H. pylori infection, including lymphocytic gastritis, granulomatous gastritis, Russell body gastritis, or crystal-storing histiocytosis. Although diverse factors can contribute to their development, there is convincing evidence that H. pylori infection may play a pathogenic role. These findings are mainly based on studies in patients with these lesions who exhibited clinical and histological improvements after H. pylori eradication therapy. Thus, H. pylori eradication therapy might be indicated in patients with no other underlying disease, particularly in countries with a high prevalence of H. pylori infection. This review describes the characteristic histological features of these rare lesions and evaluates the evidence regarding a causative role for H. pylori infection in their pathogenesis.

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Monoclonal Gammopathy of Undetermined Significance and Russell Body Formation in Helicobacter pylori Gastritis

Cited by 36 publications

References 30 publications

Helicobacter pylori and Hematologic Diseases

Helicobacter pylori and Hematologic Diseases

Russell body cervicitis: A case report and literature review

Rare Gastric Lesions Associated with Helicobacter pylori Infection: A Histopathological Review

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