Monoclonality of Composite Large Cell Neuroendocrine Carcinoma and Mucinous Epithelial Tumor of the Ovary: A Case Study

Abstract

A rare case of mixed carcinoma of the ovary is reported, composed of a large cell neuroendocrine carcinoma and a mucinous borderline endocervical tumor. The large cell neuroendocrine carcinoma was composed of solid nests, sheets, and trabeculae of medium to large-sized cells, and was positive for synaptophysin. The mucinous epithelial tumor varied in appearance from a borderline to an intraepithelial carcinoma, and showed sparsely scattered immunoreactivity for chromogranin-A. Using an X-chromosome clonality assay, these 2 components showed patterns of monoclonality. These results suggest that the large cell neuroendocrine carcinoma may have arisen from the mucinous epithelial tumor.

Role of diagnostic laparoscopy in patients with large cell neuroendocrine carcinoma of the ovary with cancerous peritonitis: case report and review of the literature

“…The clinicopathological features of 31 cases with FIGO stage I/II (Table 1) and 25 cases with FIGO stage III/IV (Table 2) [7,8,14,17,18,20,[25][26][27][28][29][30][31][32][33][34][35] were reviewed. A Kaplan-Meier survival curve (SPSS Statistics version 24; IBM, Armonk, NY) of all 53 cases excluding 3 cases without clinical outcome data showed total 5year survival of 34.6% and median survival time of 17 months.…”

“…Therefore, pathological examination has to be performed to differentiate non-epithelial ovarian cancer or other diseases including inflammation in these LCNEC cases. In the previous cases with stage III/IV [7,8,14,17,18,20,[25][26][27][28][29][30][31][32][33][34], most patients underwent laparotomy for diagnosis and treatment. However, complete surgery could not be performed in many cases, leading to the deterioration of the patients' general condition and much poorer outcomes.…”

Monoclonality of Composite Large-Cell Neuroendocrine Carcinoma and Invasive Intestinal-type Mucinous Adenocarcinoma of the Cervix

“…DNA was digested with HhaI, and the human androgen receptor gene (HUMARA) was then amplified by PCR as described previously (7,8). Amplification of the HUMARA in exon 1 was performed using the GC-RICH PCR System, dNTPack (Roche, Germany).…”

Poor prognosis of ovarian cancer with large cell neuroendocrine carcinoma: Case report and review of published works

“…World Health Organization (WHO) criteria describe that LCNEC of the lung is characterized by positive immunostaining for chromogranin A, synaptophysin or CD56 (N‐CAM) and at least one of them is enough if the staining is clear cut . LCNEC of the ovary is very rare and only 35 cases have been reported previously worldwide . Its prognosis is generally very poor, even when the diagnosis is made at an early stage.…”

“…2 LCNEC of the ovary is very rare and only 35 cases have been reported previously worldwide. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Its prognosis is generally very poor, even when the diagnosis is made at an early stage. We experienced a case of LCNEC of the ovary who died of disseminated disease within 7 months after the primary surgery despite extensive surgery and adjuvant chemotherapy.…”