Monocyte Chemoattractant Protein-1 Expression in Intimal Hyperplasia of Vein Grafts in a Rat Model

Mitsuhiro, Yasuda; Miyamoto, Takashi; Hoch,

doi:10.1007/s005950200047

Cited by 4 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently we compared rat interposition vein grafts and in situ artery grafts. Then we found IH becomes significantly larger after two weeks in vein graft, and the expression of MCP-1 rnRNA is also significantly increased in vein graft by one day [6]. In this study we have analyzed that serum MCP-1 levels already start to increase just after bypass (0 hour).…”

Section: Discussionmentioning

confidence: 80%

“…Although we found the expression of MCP-I mRNA is also significantly increased in vein graft [6], in this study we have analyzed that serum MCP-1 levels of vein graft. The advantage of serum MCP-1 levels is that it is so easy to sample, that clinically it may be more useful in near future.…”

Section: Study Limitationsmentioning

confidence: 85%

“…Group III: Just After Bypass (0 Hour) Under the microscope (OME-J&N J73507 ®, Olympus, Japan) with 30x magnification, we interposed the epigastric vein graft into the right common femoral artery, by end-to-end anastomosis with 6 to 8 interrupted sutures of 10-0 Nylon (WM4-10-0N2 ®, ELP Corporation, South Korea), as previously described [4][5][6]…”

Section: Group Ii: Before Bypassmentioning

confidence: 99%

See 2 more Smart Citations

Serum monocyte chemoattractant protein-1 levels in rat models of intimal hyperplasia

Yamamura¹,

Miyamoto²,

Yao³

2002

Int J Angiol

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 80%

Section: Study Limitationsmentioning

confidence: 85%

Section: Group Ii: Before Bypassmentioning

confidence: 99%

See 1 more Smart Citation

Serum monocyte chemoattractant protein-1 levels in rat models of intimal hyperplasia

Yamamura¹,

Miyamoto²,

Yao³

2002

Int J Angiol

Self Cite

View full text Add to dashboard Cite

“…1. 5 My research showed that endothelial injury and monocyte infiltration are the key to postoperative intimal hyperplasia, 5,6 which is very similar to the pathogenesis of atherosclerosis as an inflammatory disease "response-to-injury hypothesis" proposed by R. Ross, 7 except for the lack of smooth muscle proliferation in vein (►Fig. 2).…”

mentioning

confidence: 70%

“…3 After my vascular surgery residency in Japan, I started my research work on postoperative intimal hyperplasia at the University of Wisconsin-Madison. 4 The postoperative view under the microscope is shown in ►Fig. 1.…”

mentioning

confidence: 99%

Postoperative Intimal Hyperplasia: Review from My Research

Yamamura

2024

Int J Angiol

Self Cite

View full text Add to dashboard Cite

Postoperative intimal hyperplasia is the major cause of the vein graft occlusion. It is very important to establish an animal model for the start of research. After my vascular surgery residency in Japan, I started my research work on postoperative intimal hyperplasia at the University of Wisconsin-Madison. My research showed that endothelial injury and monocyte infiltration is the key for postoperative intimal hyperplasia, which is very similar to Ross' pathogenesis of atherosclerosis as an inflammatory disease. Focusing on postoperative intimal hyperplasia as an inflammatory disease, especially on tumor necrosis factor-α, FR-167653 (tumor necrosis factor-α suppressive agent, inhibitor of p38 mitogen-activated protein kinase; Fujisawa Pharmaceutical Co., Ltd., Japan) is found to suppress postoperative intimal hyperplasia in a rat model by reducing serum monocyte chemoattractant protein-1 levels. However, FR-167653 is not commercially available today. Because endothelial injury is the first step of postoperative intimal hyperplasia, I investigated whether the free radical scavenger, edaravone (Radicut, Mitsubishi Tanabe Pharma Co., Japan), which alleviates the endothelial injury in vitro, can also suppress postoperative intimal hyperplasia. Moreover, the free radical scavenger edaravone (Radicut®, Mitsubishi Tanabe Pharma Co.) is also found to suppress postoperative intimal hyperplasia, by alleviating endothelial injury. In clinical settings, it is very important to detect postoperative intimal hyperplasia before its establishment. Hepatocyte growth factor is not only a hepatic growth factor but also a vascular endothelial growth factor. Recently, serum hepatocyte growth factor level was found to be a candidate biomarker for postoperative intimal hyperplasia in our rat model.

show abstract

Serum monocyte chemoattractant protein-1 levels in rat models of intimal hyperplasia

2011

View full text Add to dashboard Cite

Monocyte Chemoattractant Protein-1 Expression in Intimal Hyperplasia of Vein Grafts in a Rat Model

Abstract: These results show that there could be a direct correlation between the significant increases in MCP-1 mRNA expression, Mo/Mphi infiltration, and the development of IH in vein grafts, not seen in FA anastomoses.

Cited by 4 publications

References 16 publications

Serum monocyte chemoattractant protein-1 levels in rat models of intimal hyperplasia

Serum monocyte chemoattractant protein-1 levels in rat models of intimal hyperplasia

Postoperative Intimal Hyperplasia: Review from My Research

Serum monocyte chemoattractant protein-1 levels in rat models of intimal hyperplasia

Contact Info

Product

Resources

About