Monocyte Distribution Width (MDW) as a biomarker of sepsis: An evidenced-based laboratory medicine approach

Ciaccio, Anna Maria; Agnello, Luisa; Sasso, Bruna Lo; Giglio, Rosaria Vincenza; Iacona, Alessandro; Gambino, Caterina Maria; Scazzone, Concetta; Tuttolomondo, Antonino; Ciaccio, Marcello

doi:10.1016/j.cca.2022.117214

Cited by 7 publications

(4 citation statements)

References 49 publications

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“…The population characteristics are shown in Table 1. Overall, patients had a median age of 70 (57-77) years, with an average SOFA score of 6 (4-8) and a Glasgow Coma Score (GCS) at ICU admission of 15 (9)(10)(11)(12)(13)(14)(15). Age, mean arterial pressure (MAP) and the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO 2 /FiO 2 ) on admission differed significantly between patients with and without sepsis (71 (60-78) vs. 64 (52-75) years, 79 (65-93) vs. 90 (71-107) mmHg, and 175 (116-274) vs. 303 (174-403) mmHg, respectively, p < 0.05), whereas median SOFA score was not dissimilar between the two groups.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, several studies have shown that the morphological parameters of leukocytes play an important role in the diagnosis of sepsis [12]. One example is the monocyte distribution width (MDW), a new laboratory parameter obtained from a complete blood count (CBC) that measures the morphological and dimensional variability of monocytes in the blood [13,14]. The MDW is a promising tool for the diagnosis and treatment of sepsis, and its use in clinical practice can improve outcomes in sepsis patients [15,16].…”

Section: Introductionmentioning

confidence: 99%

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The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis

Sacchetti,

Vidali,

Esposito

et al. 2024

Diagnostics

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Background: Late diagnosis of sepsis is associated with adverse consequences and high mortality rate. The aim of this study was to evaluate the diagnostic value of hematologic research parameters, that reflect the cell morphology of blood cells, available on the BC 6800 plus automated analyzer (Mindray) for the early detection of sepsis. Materials and Methods: A complete blood count (CBC) was performed by Mindray BC 6800 Plus Analyzer in 327 patients (223 with a confirmed diagnosis of sepsis following sepsis-3 criteria, 104 without sepsis), admitted at the Intensive Care Unit of the Novara’s Hospital (Italy) and in 56 patients with localized infection. Results: In univariate logistic regression, age, Hb, RDW, MO#, NMR, NeuX, NeuY, NeuZ, LymX, MonX, MonY, MonZ were associated with sepsis (p < 0.005). In multivariate analysis, only RDW, NeuX, NeuY, NeuZ, MonX and MonZ were found to be independent predictors of sepsis (p < 0.005). Morphological research parameters are confirmed to be predictors of sepsis even when analyzing the group with localized infection. Conclusions: In addition to already established biomarkers and basic CBC parameters, new morphological cell parameters can be a valuable aid in the early diagnosis of sepsis at no additional cost.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis

Sacchetti,

Vidali,

Esposito

et al. 2024

Diagnostics

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“…With the awareness that the ideal sepsis biomarker does not exist, the research is focused on identifying reliable biomarkers to assist Clinicians in the appropriate patient management, from early detection to prognostication. Although hundreds of sepsis biomarkers are currently under investigation, PSP and MDW are the most promising in terms of both accuracy and advantages over the traditional ( 9 , 19 ). A recent meta-analysis by Paraskevas et al ( 20 ), including twenty-nine studies, showed that PSP has a good accuracy for diagnosing sepsis with an area under the curve of 0.875 and a sensitivity of 81%.…”

Section: Discussionmentioning

confidence: 99%

“…However, promising biomarkers for sepsis screening are emerging. Among these, monocyte distribution width (MDW) has gained much attention in the last few years (4)(5)(6)(7)(8)(9)(10)(11)(12)(13). It is a measure of the monocyte's anisocytosis, and it is calculated by the last generation hemocytometers of Beckman Coulter.…”

Section: Introductionmentioning

confidence: 99%

Clinical usefulness of presepsin and monocyte distribution width (MDW) kinetic for predicting mortality in critically ill patients in intensive care unit

Agnello,

Ciaccio,

Ben

et al. 2024

Front. Med.

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BackgroundIn this study, we explored the accuracy of two new sepsis biomarkers, monocyte distribution width (MDW) and presepsin (PSP), compared to traditional ones, C-reactive protein (CRP) and Procalcitonin (PCT), to identify sepsis and predict intra-hospital mortality by analyzing their kinetic at different time points during hospitalization stay.MethodsWe enrolled 104 patients admitted to the intensive care unit (ICU) of University Hospital “Paolo Giaccone”, Palermo. Among these, 30 (29%) had a clinical diagnosis of sepsis. MDW, PCT, CRP, and PSP were evaluated at admission (T0), after 24 h (T24), 48 h (T48), 72 h (T72), at day 5 (T5), and at discharge (TD).ResultsPatients with sepsis displayed higher levels of PCT and PSP than patients without sepsis at each timepoint; differently, CRP displayed statistically significant differences only at T0, while MDW only at T0 and T24. Patients with increasing levels of PSP displayed lower median survival time than patients with decreasing levels; differences reached statistical significance only at 48 h (20 vs. 29 days, log rank test, p = 0.046). Interestingly, PSP was an independent predictor of ICU mortality at 48 and 72 h after hospital admission. Also, the kinetic of PSP had prognostic value, with increased values at 48 h after admission being associated with reduced survival.ConclusionOur findings support the role of PSP and its kinetic as a predictor of ICU mortality.

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Monocyte distribution width (MDW) in sepsis

Agnello

Ciaccio

Vidali

et al. 2023

Clinica Chimica Acta

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Monocyte Distribution Width (MDW) as a biomarker of sepsis: An evidenced-based laboratory medicine approach

Cited by 7 publications

References 49 publications

The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis

The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis

Clinical usefulness of presepsin and monocyte distribution width (MDW) kinetic for predicting mortality in critically ill patients in intensive care unit

Monocyte distribution width (MDW) in sepsis

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