Monocyte Phagocytic Activity in Sickle Cell Disease

Mendoza, Eduardo Cortés; Gutgsell, Nancy S.; Temple, J. Donald; Issitt, Peter D.

doi:10.1159/000204892

Cited by 15 publications

(15 citation statements)

References 8 publications

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“…Another would be that the synthetic capacity for TNF‐α in the monocytes from these patients is inherently diminished. However, previous studies by other investigators have predominantly shown that monocytes from patients with SCD function normally (Vilela et al ., 1990; Mendoza et al ., 1991) or had minimally reduced phagocytic activity (Vilela et al ., 1989).…”

Section: Discussionmentioning

confidence: 99%

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Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease*

et al. 2002

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Tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) increase endothelial surface receptors that mediate the adherence of sickle erythrocytes to the endothelium. Increased circulating levels of these cytokines have been found in patients with sickle cell disease (SCD). Monocytes are a source of both of these inflammatory mediators; we therefore determined whether circulating monocytes were activated in SCD, as defined by intracellular expression of these cytokines. Blood was also assayed for the presence of platelet-monocyte aggregates (PMAs), as platelet adherence is one possible mechanism for monocyte activation. The median percentages of monocytes expressing intracellular TNF-alpha and IL-1beta in SCD patients were 6.8 (2.8-17.3) [median (range)] and 14.1 (1.3-44.8), respectively. In African-American controls the corresponding percentages were 0.3 (0.1-0.5) and 0.4 (0.1-3.0), and in Caucasians 0.2 (0.1-0.5) and 0.8 (0.8-1.9) (P < 0.001, Kruskal-Wallis). The mean percentage (+/- SD) of PMA was 14.0 +/- 8.3 for Caucasian controls, 25.7 +/- 7.3 for African-American controls, and 45.7 +/- 21.6 for patients with SCD (P < 0.001, RM ANOVA; P < 0.05, Newman-Keuls posthoc test). We conclude that there are increased circulating PMAs and monocyte activation in patients with SCD.

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Section: Discussionmentioning

confidence: 99%

“…Open circles represent data outside the 10th and 90th percentiles. Mendoza et al, 1991) or had minimally reduced phagocytic activity (Vilela et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease*

et al. 2002

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“…For example, phagocytic activity rises during VOCs 56. Neutrophil chemotaxis is normal or clearly reduced in the steady state of the disease but increases during VOC crises57.…”

Section: Etiology Of Risks Of Infections In Thalassemia and Hemoglobimentioning

confidence: 99%

Infections in Thalassemia and Hemoglobinopathies

Ricerca¹,

Girolamo²,

Rund³

2009

Medit J Hemat Infect Dis

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The clinical approach to thalassemia and hemoglobinopathies, specifically Sickle Cell Disease (SCD), based on transfusions, iron chelation and bone marrow transplantation has ameliorated their prognosis. Nevertheless, infections still may cause serious complications in these patients. The susceptibility to infections in thalassemia and SCD arises both from a large spectrum of immunological abnormalities and from exposure to specific infectious agents. Four fundamental issues will be focused upon as central causes of immune dysfunction: the diseases themselves; iron overload, transfusion therapy and the role of the spleen. Thalassemia and SCD differ in their pathogenesis and clinical course. It will be outlined how these differences affect immune dysfunction, the risk of infections and the types of most frequent infections in each disease. Moreover, since transfusions are a fundamental tool for treating these patients, their safety is paramount in reducing the risks of infections. In recent years, careful surveillance worldwide and improvements in laboratory tests reduced greatly transfusion transmitted infections, but the problem is not completely resolved. Finally, selected topics will be discussed regarding Parvovirus B19 and transfusion transmitted infections as well as the prevention of infectious risk postsplenectomy or in presence of functional asplenia.

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“…The monocyte monolayer assay (MMA) has been used for more than 35 years to predict the hemolytic significance of a red blood cell (RBC) auto‐ or alloantibody . In recent years, this assay has been adapted to examine intravenous immunoglobulins (IVIG) implicated in postadministration hemolysis .…”

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confidence: 99%