Monodisperse Au–Fe₂C Janus Nanoparticles: An Attractive Multifunctional Material for Triple-Modal Imaging-Guided Tumor Photothermal Therapy

Abstract

Imaging-guided photothermal therapy (PTT) by combination of imaging and PTT has been emerging as a promising therapeutic method for precision therapy. However, the development of multicomponent nanoplatforms with stable structures for both PTT and multiple-model imaging remains a great challenge. Herein, we synthesized monodisperse Au-FeC Janus nanoparticles (JNPs) of 12 nm, which are multifunctional entities for cancer theranostics. Due to the broad absorption in the near-infrared range, Au-FeC JNPs showed a significant photothermal effect with a 30.2% calculated photothermal transduction efficiency under 808 nm laser irradiation in vitro. Owing to their excellent optical and magnetic properties, Au-FeC JNPs were demonstrated to be advantageous agents for triple-modal magnetic resonance imaging (MRI)/multispectral photoacoustic tomography (MSOT)/computed tomography (CT) both in vitro and in vivo. We found that Au-FeC JNPs conjugated with the affibody (Au-FeC-Z) have more accumulation and deeper penetration in tumor sites than nontargeting JNPs (Au-FeC-PEG) in vivo. Meanwhile, our results verified that Au-FeC-Z JNPs can selectively target tumor cells with low cytotoxicity and ablate tumor tissues effectively in a mouse model. In summary, monodisperse Au-FeC JNPs, used as a multifunctional nanoplatform, allow the combination of multiple-model imaging techniques and high therapeutic efficacy and have great potential for precision theranostic nanomedicines.

Short‐Wave Infrared Sensor by the Photothermal Effect of Colloidal Gold Nanorods

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Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe3O4 Heterostructures with Reduced Cytotoxicity

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