Monofocal outer retinitis associated with hand, foot, and mouth disease caused by coxsackievirus

Haamann, Per; Kessel, Line; Larsen, Michael

doi:10.1016/s0002-9394(99)00440-7

Cited by 27 publications

(24 citation statements)

References 2 publications

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“…22 HFMD is most frequently associated with coxsackievirus serotype A16 or enterovirus 71, but multiple serotypes including A2, A5, A7, A9, A10, B1, B2, B3, B4, B6 have been reported in association with HFMD. 5, 23–25 In this study, one patient had clinical signs of HFMD and developed vision loss in temporal proximity with the evolution of the skin rash and also had an elevated coxsackie A9 viral titer. While HFMD associated with coxsackievirus A16 has a more benign course, outbreaks of enterovirus 71 have been associated with serious clinical findings including encephalitis, fatal pulmonary edema and myocarditis.…”

Section: Discussionmentioning

confidence: 69%

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Multimodality Diagnostic Imaging in Unilateral Acute Idiopathic Maculopathy

et al. 2012

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Section: Discussionmentioning

confidence: 69%

“…24 In addition to HFMD, the Coxsackie virus has been associated with orchitis, epididymitis, as well as other ophthalmic pathologies. 5, 25–33 …”

Section: Discussionmentioning

confidence: 99%

Multimodality Diagnostic Imaging in Unilateral Acute Idiopathic Maculopathy

et al. 2012

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“…12 There have been several reports of coxsachievirus infections associated with chorioretinitis, unilateral acute idiopathic maculopathy, or monofocal outer retinitis and the lesions described bear some resemblance to ARPE. [13][14][15][16] In the present case, the chronology of the ocular symptoms and the systemic viral infection are in favor of a post viral reaction rather than the ocular manifestation of the viral infection itself. …”

Section: Discussionmentioning

confidence: 56%

A case of acute retinal pigment epithelitis: spectral domain optical coherence tomography time course and physiopathologic hypothesis

Puche

Offret²,

Bernard³

2010

OPTH

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Purpose:To report the time course of retinal morphologic changes in a patient with acute retinal pigment epithelitis (ARPE) using spectral domain optical coherence tomography (SD-OCT). Methods: A 30-year old man was referred for blurred vision of his right eye after five days that appeared suddenly 15 days after recovery from a flu-like syndrome. SD-OCT was performed immediately, followed by fluorescein and infracyanine angiography at eight days and then at three weeks. Results: At presentation, a bubble of sub-macular deposit was observed on the right macula with central golden micronodules in a honeycomb pattern. SD-OCT showed an "anterior dislocation" of all the retinal layers up to the inner/outer segment (IS/OS) line and irregular deposits at the OS level together with thickening of the retinal pigment epithelial (RPE) layer. As visual acuity increased, eight days later, the OCT showed reduction of the sub-retinal deposits and an abnormal hyperflectivity of the sub-retinal and RPE layers was observed. The patient showed a positive serology for picornavirus. Discussion: The acute SD-OCT sections of this patient with ARPE were compared with histological sections of a 35 day old Royal College of Surgeons rat. Similar findings could be observed, with preservation of the IS/OS line and accumulation of debris at the OS level, suggesting that ARPE symptoms could result from a transient phagocytic dysfunction of the RPE at the fovea, inducing reversible accumulation of undigested OS. Picornaviruses comprising enterovirus and coxsachievirus described as being associated with acute chorioretinitis. In this case, it was responsible for ARPE. Conclusion: We hypothesize that ARPE syndrome results from a transient dysfunction of RPE, which can occur as a post viral reaction.

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“…Coxsackie virus is a member of the picornaviridae family, which are single-stranded positive sense RNA viruses. Hand-foot-mouth disease is the common systemic presentation of coxsackie virus infection with type A16 being the most frequent, although serotypes A2, A5, A7, A9, A10, B1, B2, B3, B4, B6, and enterovirus 71 have also been found to be causative 24,26 . Coxsackie virus serotypes B3 and B4 have also been associated with posterior segment inflammation 26,27 .…”

Section: Coxsackie Virus-associated Unilateral Acute Idiopathic Maculmentioning

confidence: 99%

“…Hand-foot-mouth disease is the common systemic presentation of coxsackie virus infection with type A16 being the most frequent, although serotypes A2, A5, A7, A9, A10, B1, B2, B3, B4, B6, and enterovirus 71 have also been found to be causative 24,26 . Coxsackie virus serotypes B3 and B4 have also been associated with posterior segment inflammation 26,27 . In vitro studies have demonstrated the ability of the virus to replicate inside retinal pigment epithelial (RPE) cells 27 .…”

Section: Coxsackie Virus-associated Unilateral Acute Idiopathic Maculmentioning

confidence: 99%