Monolithic High-Performance SEC Supports Prepared by ROMP for High-Throughput Screening of Polymers

Liquid chromatography of polymers is traditionally a slow technique with analysis times of typically 30 min per sample. For the application of liquid chromatographic techniques to combinatorial materials research the analysis time per sample must be reduced considerably. Analysis time in SEC can be reduced to about 2 min per sample when high‐throughput columns are used. For HPLC small columns with improved separation efficiencies can be used. As compared to conventional technology, time savings of more than 80% are achieved. Chromatogram from conventional SEC column compared to high‐speed SEC column tested on an identical instrument with polystyrene standards in THF.magnified imageChromatogram from conventional SEC column compared to high‐speed SEC column tested on an identical instrument with polystyrene standards in THF.

Section: Methods For High-throughput Hplcmentioning

confidence: 99%

Fast Liquid Chromatography for High‐Throughput Screening of Polymers

Pasch

Kilz

2003

“…[90,91] Due to the progress in developing monolithic materials, the availability of new types of columns can be expected in the near future. [92][93][94] Almost all parallel synthetic approaches described up to now utilize conventional GPC systems for screening purposes (see, e.g., ref. [40][41][42][43] ), thus facing a significant bottleneck regarding the most important parameters in polymer characteristics: the molecular weight and its distribution.…”

Section: Screening Of Molecular Weightsmentioning

confidence: 99%

Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: Past and Present

Hoogenboom

Meier

Schubert

2003

203

160

Combinatorial techniques, parallel experimentation and high‐throughput methods represent a very promising approach in order to speed up the preparation and investigation of new polymeric materials: a large variety of parameters can be screened simultaneously resulting in new structure/property relationships. The field of polymer research seems to be perfectly suited for parallel and combinatorial methods due to the fact that many parameters can be varied during synthesis, processing, blending as well as compounding. In addition, numerous important parameters have to be investigated, such as molecular weight, polydispersity, viscosity, hardness, stiffness and other application‐specific properties. A number of corresponding high‐throughput techniques have been developed in the last few years and their introduction into the commercial market further boosted the development. These combinatorial approaches can reduce the time‐to‐market for new polymeric materials drastically compared to traditional approaches and allow a much more detailed understanding of polymers from the macroscopic to the nanoscopic scale. Here we provide an overview of the present status of combinatorial and parallel polymer synthesis and high‐throughput screening.magnified image

“…Norborn-2-ene-5-methanol was purchased form Greyhound Chromatography, U.K. A ruthenium standard containing 1 000 ppm of ruthenium was purchased from Alfa Aesar/Johnson Matthey (Karlsruhe, Germany). Tris(norborn-2-en-5-yl-methylenoxy)methylsilane ((NBE-CH 2 O) 3 -SiCH 3 ), [22] was prepared according to literature procedures and checked for purity by means of NMR spectroscopy.…”

Section: Experimental Partmentioning

confidence: 99%

Heterogenization of a Modified Grubbs–Hoveyda Catalyst on a ROMP‐Derived Monolithic Support

Krause

Lubbad

Nuyken

et al. 2003

Self Cite

106

A ring‐opening metathesis polymerization‐ (ROMP‐) based monolith was synthesized using a Grubbs' first generation catalyst. The living termini were used for surface grafting of norborn‐5‐ene‐2‐ylmethyl hexafluoroglutarate. The free carboxylic acid groups of the graft polymer were converted into the corresponding silver salt and reacted with the Grubbs–Hoveyda catalyst [RuCl2(CH(2‐iPrO)C6H4)(IMesH2)] (IMesH2 = 1,3‐bis(2,4,6‐trimethylphenyl)‐4,5‐dihydroimidazol‐2‐ylidene) to yield a stable heterogeneous version of this catalyst for use in ring‐closing metathesis (RCM) under continuous flow conditions.The monolith‐supported Grubbs–Hoveyda catalyst.magnified imageThe monolith‐supported Grubbs–Hoveyda catalyst.