Monosodium glutamate induces memory and hepatic dysfunctions in mice: ameliorative role of Jobelyn® through the augmentation of cellular antioxidant defense machineries

Omogbiya, A.I.; Ben‐Azu, Benneth; Eduviere, Anthony T.; Eneni, Aya-Ebi Okubo; Nwokoye, Prisilla O; Ajayi, Abayomi Mayowa; Umukoro, Solomon

doi:10.1007/s43188-020-00068-9

Cited by 15 publications

(21 citation statements)

References 47 publications

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“…This reflects an alteration in memory capacity [ 56 ]. These results are in agreement with those obtained by Omogbiya et al [ 57 ] who showed that the repeated administration of high doses of MSG altered spatial working memory. However, all doses of the extract resulted in a significant ( p < 0.001) increase in the direct search strategy and a significant ( p < 0.01) decrease in the time taken to find the target hole.…”

Section: Discussionsupporting

confidence: 93%

Antioxidant and Anticholinesterase Properties of the Aqueous Extract of Balanites aegyptiaca L. Delile Fruit Pulp on Monosodium Glutamate-Induced Excitotoxicity in Swiss Mice

Bouvourné

Beppe

Ponka

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Balanites aegyptiaca L. Delile (B. aegyptiaca) is used in traditional medicine for the treatment of memory impairment. This work aims to evaluate the antioxidant and anticholinesterase potential of BA fruit pulp extract on excitotoxicity induced by monosodium glutamate (MSG). MSG was administered 30 minutes after treatment with B. aegyptiaca aqueous fruit pulp extract (50, 125, 250, and 500 mg/kg) and vitamin C (100 mg/kg) for 30 days. The negative control group received only MSG, while the control group was given distilled water daily. Behavioral tests parameters (using the novel object recognition, Y-maze, and Barnes maze tests), oxidative stress biomarkers (malondialdehyde, superoxide dismutase, and catalase), nitric oxide, and acetylcholinesterase activity and hippocampal architecture were evaluated. Results obtained revealed that different doses of B. aegyptiaca significantly reversed the deleterious effect of MSG on memory. This was displayed by a significant ( p < 0.05 ) increment in the percentage of spontaneous alternation in the Y-maze test and a significant ( p < 0.001 ) increase in discrimination index in novel object recognition observed with 500 mg/kg extract dose. Moreover, the extract (250 and 500 mg/kg doses) significantly ( p < 0.001 ) increased direct search strategy and significantly decreased ( p < 0.01 ) the time taken to find the target hole in the Barnes maze. A modulation of hyperactivity was observed after administration of all extract doses compared to the negative control group in the open arena. Furthermore, the highest dose of the extract caused a significant ( p < 0.001 ) improvement in antioxidant enzymes activity, associated with a significant ( p < 0.001 ) decrement in nitric oxide and malondialdehyde concentrations and a significant ( p < 0.01 ) decrease in acetylcholinesterase activity. Treatment with the extract also restored normal hippocampal cell architecture. B. aegyptiaca fruit pulp extract could thus confer neuroprotection through its antioxidant and anticholinesterase potential.

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Section: Discussionsupporting

confidence: 93%

Antioxidant and Anticholinesterase Properties of the Aqueous Extract of Balanites aegyptiaca L. Delile Fruit Pulp on Monosodium Glutamate-Induced Excitotoxicity in Swiss Mice

Bouvourné

Beppe

Ponka

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Also in this study, triglyceride level was significantly (p<0.05) elevated while high-density lipoprotein was significantly (p<0.05) diminished in the sleep deprived group (Table 3). Literary evidence has associated sleep disorders with serious complications like type 2 diabetes mellitus 23 and glucose intolerance or insulin resistance 24 .The liver which is the site of metabolism is particularly vulnerable to oxidative stress thus predisposing the organism to further damage 25,26 . Results from this study also support this evidence with sleep deprived mice showing a significant (p<0.05) elevation in nitrite levels and decrease in antioxidant levels (Table 4).…”

Section: Resultsmentioning

confidence: 99%

Quercetin Modulates Behavioural and Biochemical Alterations in Stressed Mice

Eduviere

Moke

Omogbiya

et al. 2021

Biosci., Biotech. Res. Asia

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Disruption of the active phase of sleep alters the physiological homeostasis of the body and results in oxidative breakdown which may trigger a wide array of defects. The central nervous system and the metabolic system are some of the most affected systems as described in several literatures. Some plant based compounds with antioxidant property have been previously described in the abrogation of the deleterious effects of active sleep disruption. One of such compounds is quercetin. This study was premeditated to expatiate on the probable neuroprotective effect of quercetin on mice exposed to 72hr active sleep disruption. Mice were allotted into five treatment groups (n = 6): group 1 served as control, group 2 received 10 mL/kg vehicle, groups 3 and 4 received 25 and 50 mg/kg quercetin respectively, and group 5 received 50 mg/kg astaxanthin. Treatment lasted for 7 days while groups 2-5 were exposed to the sleep deprivation protocol starting from day 4. Behavioural tests followed by biochemical assays and histopathological changes in the prefrontal cortex were evaluated. Data were analysed by ANOVA set at p<0.05 significance. The results revealed that quercetin, in both doses, significantly amplified memory performance, attenuated depression-like behaviour, replenished catalase and superoxide dismutase, attenuated nitric oxide levels in brain and liver of mice when compared to control group and protected against loss of prefrontal cortex neurons. In conclusion, quercetin possesses protective effects against sleep deprivation-induced brain damage.

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“…The present study was undertaken to assess the ability of Ceiba pentandra stem bark methanol extract to mitigate MSG-induced cardiometabolic syndrome (CMS). The popularity of MSG as a food additive is worldwide recognized and it is the most extensively consumed food additive [ 35 ]. It is incorporated in the composition of many processing food products and for daily house cooking dishes [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…The popularity of MSG as a food additive is worldwide recognized and it is the most extensively consumed food additive [ 35 ]. It is incorporated in the composition of many processing food products and for daily house cooking dishes [ 35 , 36 ]. Many studies have reported the deleterious effects of MSG consumption including memory and hepatic dysfunctions, obesity, and insulin resistance [ 35 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is incorporated in the composition of many processing food products and for daily house cooking dishes [ 35 , 36 ]. Many studies have reported the deleterious effects of MSG consumption including memory and hepatic dysfunctions, obesity, and insulin resistance [ 35 , 37 ]. Fouda et al (2020) [ 38 ] recently observed the development of arterial hypertension in this model.…”

Section: Discussionmentioning

confidence: 99%

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The methanol extract of Ceiba pentandra reverses monosodium glutamate-induced cardiometabolic syndrome in rats via the regulation of dyslipidemia, inflammation, oxidative stress, and insulin sensitization

Wuyt¹,

Nguelefack‐Mbuyo²,

Fofié³

et al. 2023

Heliyon

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Monosodium glutamate induces memory and hepatic dysfunctions in mice: ameliorative role of Jobelyn® through the augmentation of cellular antioxidant defense machineries

Cited by 15 publications

References 47 publications

Antioxidant and Anticholinesterase Properties of the Aqueous Extract of Balanites aegyptiaca L. Delile Fruit Pulp on Monosodium Glutamate-Induced Excitotoxicity in Swiss Mice

Antioxidant and Anticholinesterase Properties of the Aqueous Extract of Balanites aegyptiaca L. Delile Fruit Pulp on Monosodium Glutamate-Induced Excitotoxicity in Swiss Mice

Quercetin Modulates Behavioural and Biochemical Alterations in Stressed Mice

The methanol extract of Ceiba pentandra reverses monosodium glutamate-induced cardiometabolic syndrome in rats via the regulation of dyslipidemia, inflammation, oxidative stress, and insulin sensitization

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