Monosynaptic connections between histamine-containing neurons and their various follower cells

Histamine as a Neuroregulator

“…C2 stimulation produces depression of the endogenous spiking of these cells. Additional responses to C2 firing were also mimicked by histamine when recordings were made near the axon processes (McCaman & McKenna 1978, McCaman & Weinreich 1982. In response to C2 firing, another class of followers demonstrated a rise in firing rate characterized by a short duration fast-excitatory PSP and a long duration slow-excitatory PSP ; both were mimicked by histamine (Weinreich 1977).…”

“…The depression of each spike was qualitatively mimicked by application of histamine (Weinreich 1977). The C2 neurons and followers were postulated (McCaman & McKenna 1978) to comprise an "elementary divergent aggregate" system in which C2 neurons have a functional role as "multiaction interneurons." Additional responses to C2 firing were also mimicked by histamine when recordings were made near the axon processes (McCaman & McKenna 1978, McCaman & Weinreich 1982.…”

La β-alanylation, une voie de neutralisation de l'histamine dans le système nerveux central de Carcinus maenas

“…Csrnrne ces divers srganes semblent egalernent incapables de la dCgrader sous une autre f o m e , elle serait depoumue de toute L'histamine a deja et6 impliquee comrne neurotransmetteur ou neuromodulateur chez divers mollusques (Weinrelch sr a!. 1975;Weinreich 1977;Turner et Cottrell 1977: McCaman et McKenna 1978Gotow et ak. 19806s, 198069); Sclawartz et ak, 1986).…”

Effect of histamine on the hippocampal neurons in guinea-pigs

“…It has been shown that the depressant action of Hi on neuronal activity is mediated by H 2 receptors [3,8,13], but this has not yet been fully substantiated. Much solid evidence that Hi acts as a neurotransmitter was obtained in a mollusc preparation [15,16]. However, the relevance of these data to the mammalian CNS remains doubtful [ 17].…”