Monosynaptic EPSPs elicited by single interneurones and spindle afferents in trigeminal motoneurones of anaesthetized rats.

Grimwood, Paul; Appenteng, Kwabena; Curtis, John C.

doi:10.1113/jphysiol.1992.sp019320

Cited by 31 publications

(29 citation statements)

References 35 publications

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“…For the jaw muscles, estimates of projection frequency from single spindle afferents to homonymous motoneurons are also low: 10% for cat masseter (Appenteng, O'Donovan, Somjen, Stephens & Taylor, 1978), 50% for rat masseter (Grimwood, Appenteng & Curtis, 1992) and 30% for guinea-pig lateral pterygoid (Nozaki, Iriki & Nokamura, 1985). Grimwood et al (1992) (Appenteng et al 1978).…”

Section: Stretch Velocity and Single Motor Unit Responsesmentioning

confidence: 99%

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Responses of human masseter motor units to stretch.

Miles

Poliakov

Nordstrom

1995

The Journal of Physiology

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1. The reflex responses to stretch were studied in single motor units and the surface electromyogram in human masseter. 2. Controlled stretches of the isometrically contracting jaw-closing muscles evoked shortlatency (10-15 ms) and long-latency (35-70 ms) excitatory reflex responses in the masseter surface electromyogram. 3. The majority (65%) of tonically active masseter motor units were excited in both shortand long-latency phases of the reflex. The timing of the stimulus determined whether the unit discharged in the short-or long-latency phase. If a non-tonically active motor unit was recruited by the stimulus, it invariably discharged in the long-latency phase. 4. Although short-latency responses were strongly time-locked to the stimulus, there was very little shortening of interspike intervals (ISIs) in this phase of the reflex. The shortening of ISIs was more prominent and prolonged during the long-latency phase, which explains why this phase produces most of the reflex force changes following the stretch. 5. Within pairs of concurrently active motor units there was a tenfold range in the size of the short-latency response to the same stretch. 6. A substantial proportion (35%) of the twenty-two masseter motor units tested had no statistically significant short-latency reflex response. 7. In contrast to other human muscles, there was no functional connection between a population of Ia afferents and some masseter motoneurons. There are two possible explanations for this result. The short-latency, presumably monosynaptic, Ia afferent inputs may not be uniformly distributed to human masseter motoneurons.

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Section: Stretch Velocity and Single Motor Unit Responsesmentioning

confidence: 99%

“…Grimwood et al (1992) (Appenteng et al 1978). In the cat, it seems that all masseter motoneurons participate in stretch reflexes, but the average strength of individual and overall spindle projections is weak.…”

Section: Stretch Velocity and Single Motor Unit Responsesmentioning

confidence: 99%

Responses of human masseter motor units to stretch.

Miles

Poliakov

Nordstrom

1995

The Journal of Physiology

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“…The experiments were performed on rats anaesthetized with pentobarbitone (initial dose 60 mg kg-l I.V. ), paralysed and artificially ventilated (Grimwood et al 1992). Paired pulse stimulation at intervals of 5-19 ms produced significant potentiation of transmission (Fig.…”

Section: Supported By the Uk-dutch Joint Scientific Researchmentioning

confidence: 99%

Sensorimotor Control

1994

The Journal of Physiology

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“…25,157-165. Taylor, A., Elias, S.A. & Sormjen, G. (1987 (Grimwood et al 1992). Using paired pulse testing we have shown that these unitary EPSPs can undergo potentiation and that the potentiation can be ascribed to an increase in release probability (Grimwood & Appenteng, 1993).…”

mentioning

confidence: 99%

“…The experiments were performed on rats which were anaesthetized with pentobarbitone (initial dose 60 mg kg-') and paralysed with gallamine triethiodide and artificially ventilated as described by Grimwood et al (1992 The fatiguing contractions caused compression at all contraction levels. The EMIG median frequencies fell from 108 to 67 Hz at 40 % MVC and from 93 to 59 Hz at AIVC.…”

mentioning

confidence: 99%

CNS

1994

The Journal of Physiology

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We have used both eletrophysiological and ultrastructural methods to determine if glutamate may act as an excitatory transmitter at synapses on to trigeminal motoneurones. The electrophysiological experiments consisted of recording minature EPSP activity from trigeminal motoneurones and assessing the effect on this activity of application of 6-cyano-7-nitroquinoxaline-2-3-dione (CNQX), an antagonist of the AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) sub-type of the glutamate receptor. The preparation used was a tissue slice preparation (500 /am thickness) taken from animals aged 8 days. The slices were maintained at 25°C in an interface chamber where they were perfused with ACSF containing tetrodotoxin (0-6 /SM). The whole-cell patch

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Monosynaptic EPSPs elicited by single interneurones and spindle afferents in trigeminal motoneurones of anaesthetized rats.

Cited by 31 publications

References 35 publications

Responses of human masseter motor units to stretch.

Responses of human masseter motor units to stretch.

Sensorimotor Control

CNS

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