Monosynaptic inputs to specific cell types of the intermediate and deep layers of the superior colliculus

Doykos, Ted K.; Gilmer, Jesse I.; Person, Abigail L.; Felsen, Gidon

doi:10.1002/cne.24888

Cited by 32 publications

(25 citation statements)

References 110 publications

(167 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These optogenetic manipulations could exert their effect indirectly by recruiting polysynaptic inhibitory pathways through the basal ganglia 56 , excitatory-inhibitory commissural SC circuitry 57 , or other mechanisms. Alternatively, these results may reflect direct effects on SC neurons.…”

Section: Resultsmentioning

confidence: 99%

Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior

et al. 2020

View full text Add to dashboard Cite

Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise role of specific circuits remains unclear. We examined the sensorimotor function of anatomically distinct outputs from a subdivision of the mouse PFC, the anterior cingulate cortex (ACC). Using a visually guided two-choice behavioral paradigm with multiple cue-response mappings, we dissociated the sensory and motor response components of sensorimotor control. Projection-specific two-photon calcium imaging and optogenetic manipulations show that ACC outputs to the superior colliculus, a key midbrain structure for response selection, principally coordinate specific motor responses. Importantly, ACC outputs exert control by reducing the innate response bias of the superior colliculus. In contrast, ACC outputs to the visual cortex facilitate sensory processing of visual cues. Our results ascribe motor and sensory roles to ACC projections to the superior colliculus and the visual cortex and demonstrate for the first time a circuit motif for PFC function wherein anatomically non-overlapping output pathways coordinate complementary but distinct aspects of visual sensorimotor behavior.

show abstract

Section: Resultsmentioning

confidence: 99%

Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior

et al. 2020

View full text Add to dashboard Cite

show abstract

“…SNr, PPTg, and motor cortex) directly project to the SC and may provide motor signals to the SC (Comoli et al, 2012). This speculation was supported by a recent study showing that the projection from the SNr is the strongest among the above motor-related brain areas (Doykos et al, 2020). The axons of GABAergic SNr neurons terminate in the lateral part of deep layers of the SC (Kaneda et al, 2008), a region that contains SNc-projecting SC neurons studied here.…”

Section: Discussionmentioning

confidence: 60%

The SC-SNc pathway boosts appetitive locomotion in predatory hunting

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

Appetitive locomotion is essential for organisms to approach rewards, such as food and prey. How the brain controls appetitive locomotion is poorly understood. In a naturalistic goal-directed behavior—predatory hunting, we demonstrate an excitatory brain circuit from the superior colliculus (SC) to the substantia nigra pars compacta (SNc) to boost appetitive locomotion. The SC-SNc pathway transmitted locomotion-speed signals to dopamine neurons and triggered dopamine release in the dorsal striatum. Activation of this pathway increased the speed and frequency of approach during predatory hunting, an effect that depended on the activities of SNc dopamine neurons. Conversely, synaptic inactivation of this pathway impaired appetitive locomotion but not defensive or exploratory locomotion. Together, these data revealed the SC as an important source to provide locomotion-related signals to SNc dopamine neurons to boost appetitive locomotion.

show abstract

“…inhibitory RD to our injection sites, and it lies ~2mm dorsal to and at shallower angle than the nigra and our 361 injection locations. Furthermore, despite the abundant inhibitory projections from the ZI to the 362 SC, the projection strength to PDB neurons appears to be minimal (Doykos et al, 2020). The use 363 of the GAD2-Cre mouse also ensured that the activation was specific to GABA containing neurons 364…”

Section: Discussion 339mentioning

confidence: 99%

Optogenetic activation of the inhibitory nigro-collicular circuit evokes orienting movements in mice

Villalobos¹,

Basso²

2020

Preprint

View full text Add to dashboard Cite

In contrast to predictions from the current model of basal ganglia (BG) function, we report here that increasing inhibition from the BG to the superior colliculus (SC) through the substantia nigra (nigra) using in vivo optogenetic activation of GABAergic terminals in mice, produces contralateral orienting movements. Orienting movements resulting from activation of inhibitory nigral terminals are unexpected because decreases and not increases, in nigral activity are generally associated with orienting movements. To determine how orienting movements may result from activation of inhibitory terminals, we performed a series of slice experiments and found that the same optogenetic stimulation of nigral terminals used in vivo, evoked post-inhibitory rebound depolarization and spiking in SC output neurons in vitro. Only high frequency (100Hz) stimulation evoked contralateral movements in vivo and triggered rebound spiking in vitro. The latency of orienting movements relative to the stimulation in vivo was similar to the latency of rebound spiking in vitro. Taken together, our results point toward a novel hypothesis that inhibition from the BG may play an active rather than passive role in the generation of orienting movements in mice.

show abstract

Monosynaptic inputs to specific cell types of the intermediate and deep layers of the superior colliculus

Cited by 32 publications

References 110 publications

Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior

Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior

The SC-SNc pathway boosts appetitive locomotion in predatory hunting

Optogenetic activation of the inhibitory nigro-collicular circuit evokes orienting movements in mice

Contact Info

Product

Resources

About