Monotremes and Marsupials

Higgins, Damien P.; Rose, Karrie; Spratt, David M.

doi:10.1016/b978-0-12-805306-5.00018-3

Cited by 5 publications

(2 citation statements)

References 91 publications

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“…Low genetic diversity and increasing genetic load are believed to be depressing tness in these wild populations. Some examples of the increasing genetic disorders exhibited in the wild include testicular abnormalities due to cryptorchidism (Cristescu et al, 2009;Seymour et al, 2001;Speight et al, 2018), kidney failure associated with the renal disease oxalate nephrosis (Speight et al, 2018), and skeletal disorders such as osteochondromas (Can eld et al, 1990;Hanger & Loader, 2014;Sutton, 1986), microphthalmia and scoliosis (Higgins et al, 2018). Other traits with negative impacts on tness have been identi ed in captive koala colonies across the globe, including acetabulum dysplasia (Can eld & Spencer, 1993; Pye et al, 2008) and jaw dysplasia (Crompton et al, 2010;Lanyon & Sanson, 1986;Pettett et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Measures of inbreeding and heterozygosity-fitness correlations in koalas (Phascolarctos cinereus) from south-east Queensland, Australia

Hulse,

Thia,

Schultz

et al. 2023

Preprint

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Inbreeding threatens many species of conservation concern. Inbreeding decreases heterozygosity (increases homozygosity) and can drive up a population’s genetic load as deleterious mutations increase in frequency. Understanding how declining heterozygosity translates into declining fitness is of high importance for conservation practitioners. In this study, we investigated the potential effects of inbreeding on fitness traits in captive and wild populations of the iconic koala (Phascolarctos cinereus) from south-east Queensland, Australia. Using 5,757 ddRAD SNPs, we found that our sampled koalas were separated into three genetic groups: a captive group (N = 36) and two genetically distinct wild groups that were divided into northern (N = 41) and southern (N = 50) populations in the Gold Coast area. Inbreeding coefficients (FIS) were slightly lower in the captive population (0.003) compared to the wild northern (0.088). While the FIS value of the southern population (-0.006) suggests minimal inbreeding within the population. Heterozygosity-fitness correlations between four fitness traits (reproductive fitness, body mass, body condition score and disease expression) and SNP heterozygosity in each of the wild groups were non-significant. This lack of signal may have been due to small effect sizes (lower power), the greater influence of environmental contributors to measured traits, and/or possibly insufficient variation in inbreeding within the populations.

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Section: Introductionmentioning

confidence: 99%

Measures of inbreeding and heterozygosity-fitness correlations in koalas (Phascolarctos cinereus) from south-east Queensland, Australia

Hulse,

Thia,

Schultz

et al. 2023

Preprint

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“…Of all marsupial species, koalas have the most documented cases, with a high prevalence of lymphoma. 4,8 There has also been a case of cholangiocarcinoma in a koala. 4 A survey of neoplasia in red kangaroos ( Macropus rufus ) showed that most tumors were malignant including mammary gland adenocarcinomas, which metastasized to the lymph nodes and lungs, lymphoma, and squamous cell carcinoma.…”

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confidence: 99%

Cholangiocarcinoma with carcinomatosis in a sugar glider

Williams,

Brum Rosa

2024

J VET Diagn Invest

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A 7-y-old, castrated male, leucistic sugar glider ( Petaurus breviceps) was presented because of a progressive history of lethargy, ataxia, diarrhea, and anorexia. Abdominal ultrasound revealed fluid in the abdomen and an infiltrative mass in the liver. Due to a poor prognosis, euthanasia was performed. Postmortem examination revealed a focally extensive, infiltrative, off-white, firm mass in the liver with adhesion to the omentum, mesentery, gastric serosa, and diaphragm. The remaining hepatic parenchyma was diffusely yellow. Histologically, the hepatic mass was consistent with metastatic cholangiocarcinoma (cholangiocellular carcinoma) with proliferation of neoplastic epithelial cells surrounded by marked desmoplasia. Neoplastic cells expanded and infiltrated the adjacent omentum, mesentery, and the serosal surfaces of the stomach, kidney, and small and large intestines. To our knowledge, cholangiocarcinoma has not been reported previously in a sugar glider.

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General Introduction: Mammalia

Rodríguez

2022

Wild and Exotic Animal Ophthalmology

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Monotremes and Marsupials

Cited by 5 publications

References 91 publications

Measures of inbreeding and heterozygosity-fitness correlations in koalas (Phascolarctos cinereus) from south-east Queensland, Australia

Measures of inbreeding and heterozygosity-fitness correlations in koalas (Phascolarctos cinereus) from south-east Queensland, Australia

Cholangiocarcinoma with carcinomatosis in a sugar glider

General Introduction: Mammalia

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