Monte Carlo Modeling of Light Propagation in Neonatal Skin

Atencio, J. A. Delgado; Jacques, Steven L.; Montiel, S. Va zquez y.

doi:10.5772/15853

Cited by 8 publications

(11 citation statements)

References 21 publications

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“…17,32,38 The results of C m exhibited very low values distributed within the range from 0 to 2 vol.%, which is consistent with the fact that albino rats were used in this study. Delgado Atencio et al 40 have proposed a three-step inverse algorithm for the estimation of melanin, total blood, and bilirubin. In this algorithm, the first step is to estimate the concentration of melanin only on the basis of the diffuse reflectance at 700 nm.…”

Section: Resultsmentioning

confidence: 99%

Measuring and imaging of transcutaneous bilirubin, hemoglobin, and melanin based on diffuse reflectance spectroscopy

Minakawa,

Wares,

Nakano

et al. 2023

J. Biomed. Opt.

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.SignificanceEvaluation of biological chromophore levels is useful for detection of various skin diseases, including cancer, monitoring of health status and tissue metabolism, and assessment of clinical and physiological vascular functions. Clinically, it is useful to assess multiple different chromophores in vivo with a single technique or instrument.AimTo investigate the possibility of estimating the concentration of four chromophores, bilirubin, oxygenated hemoglobin, deoxygenated hemoglobin, and melanin from diffuse reflectance spectra in the visible region.ApproachA new diffuse reflectance spectroscopic method based on the multiple regression analysis aided by Monte Carlo simulations for light transport was developed to quantify bilirubin, oxygenated hemoglobin, deoxygenated hemoglobin, and melanin. Three different experimental animal models were used to induce hyperbilirubinemia, hypoxemia, and melanogenesis in rats.ResultsThe estimated bilirubin concentration increased after ligation of the bile duct and reached around 18 mg / dl at 50 h after the onset of ligation, which corresponds to the reference value of bilirubin measured by a commercially available transcutaneous bilirubin meter. The concentration of oxygenated hemoglobin and that of deoxygenated hemoglobin decreased and increased, respectively, as the fraction of inspired oxygen decreased. Consequently, the tissue oxygen saturation dramatically decreased. The time course of melanin concentration after depilation of skin on the back of rats was indicative of the supply of melanosomes produced by melanocytes of hair follicles to the growing hair shaft.ConclusionsThe results of our study showed that the proposed method is capable of the in vivo evaluation of percutaneous bilirubin level, skin hemodynamics, and melanogenesis in rats, and that it has potential as a tool for the diagnosis and management of hyperbilirubinemia, hypoxemia, and pigmented skin lesions.

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Section: Resultsmentioning

confidence: 99%

Measuring and imaging of transcutaneous bilirubin, hemoglobin, and melanin based on diffuse reflectance spectroscopy

Minakawa,

Wares,

Nakano

et al. 2023

J. Biomed. Opt.

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“…] y un peso molecular [ ] de la molécula de bilirrubina [5], obteniendo así una expresión para el coeficiente de absorción debido a la bilirrubina [6]:…”

Section: A Modelo Y Simulación De La Pielunclassified

“…donde es la saturación de oxígeno de la sangre, , 2 ( ) y , ( ) son los coeficientes de absorción de la hemoglobina oxigenada ( 2 ) y la desoxigenada ( ) respectivamente [6]:…”

Section: A Modelo Y Simulación De La Pielunclassified

Retrieving the absorption coefficient of epidermis in human skin

Narea¹,

Vivas²,

Muñoz³

2015

Opt. Pura Apl.

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La forma de estudiar la piel humana, comienza con la determinación del fototipo de la misma. Sin embargo, este concepto puede enmascarar una serie de características implícitas, que en la actualidad se pueden determinar por medio de técnicas ópticas no invasivas, como la espectrofotometría de reflexión difusa. Aunque el fototipo está determinado por muchos factores, la melanina que se encuentra distribuida en la epidermis es el principal agente absorbente, determina en gran parte el color de la piel. De tal manera, que resultaría interesante conocer la cantidad y distribución de la melanina. Con este estudio, se pretende ajustar con series trigonométricas los datos espectrales para encontrar una dependencia directa entre el término

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“…To make the simulation of reflectance, the Monte Carlo method [12]; to do this, as input parameters the following were used: absorption coefficient ( [12], we was used to acquire the diffuse reflectance for turbid media.…”

Section: Generation Of the Curves Of Spectral Reflectance And Adjustmmentioning

confidence: 99%

Parameterization using Fourier series expansion of the diffuse reflectance of human skin to vary the concentration of the melanocytes

et al. 2013

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Human skin has been studied in numerous investigations, given the interest in knowing information about physiology, morphology and chemical composition. These parameters can be determined using non invasively optical techniques in vivo, such as the diffuse reflectance spectroscopy. The human skin color is determined by many factors, but primarily by the amount and distribution of the pigment melanin. The melanin is produced by the melanocytes in the basal layer of the epidermis. This research characterize the spectral response of the human skin using the coefficients of Fourier series expansion. Simulating the radiative transfer equation for the Monte Carlo method to vary the concentration of the melanocytes (f me ) in a simplified model of human skin. It fits relating the Fourier series coefficient a 0 with f me . Therefore it is possible to recover the skin biophysical parameter.

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Monte Carlo Modeling of Light Propagation in Neonatal Skin

Cited by 8 publications

References 21 publications

Measuring and imaging of transcutaneous bilirubin, hemoglobin, and melanin based on diffuse reflectance spectroscopy

Measuring and imaging of transcutaneous bilirubin, hemoglobin, and melanin based on diffuse reflectance spectroscopy

Retrieving the absorption coefficient of epidermis in human skin

Parameterization using Fourier series expansion of the diffuse reflectance of human skin to vary the concentration of the melanocytes

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