Monte Carlo simulation of flock-level sensitivity of abattoir surveillance for ovine paratuberculosis

Abbott, K. A.; Whittington, Richard J.

doi:10.1016/j.prevetmed.2003.08.005

Cited by 13 publications

(21 citation statements)

References 19 publications

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“…The gross pathology associated with MAP infection, which includes enlargement of mesenteric and ileocaecal lymph nodes and thickening of the intestinal mucosa is not specific to paratuberculosis, and gross changes do not occur in all affected animals [ 76 – 80 ]. Cording of lymphatic vessels in the serosa, mesentery and associated lymph nodes is due to advanced granulomatous inflammation, usually in late stages of pathogenesis.…”

Section: Characteristics Of Diagnostic Tests For Paratuberculosismentioning

confidence: 99%

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Case definition terminology for paratuberculosis (Johne’s disease)

et al. 2017

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Paratuberculosis (Johne’s disease) is an economically significant condition caused by Mycobacterium avium subsp. paratuberculosis. However, difficulties in diagnosis and classification of individual animals with the condition have hampered research and impeded efforts to halt its progressive spread in the global livestock industry. Descriptive terms applied to individual animals and herds such as exposed, infected, diseased, clinical, sub-clinical, infectious and resistant need to be defined so that they can be incorporated consistently into well-understood and reproducible case definitions. These allow for consistent classification of individuals in a population for the purposes of analysis based on accurate counts. The outputs might include the incidence of cases, frequency distributions of the number of cases by age class or more sophisticated analyses involving statistical comparisons of immune responses in vaccine development studies, or gene frequencies or expression data from cases and controls in genomic investigations. It is necessary to have agreed definitions in order to be able to make valid comparisons and meta-analyses of experiments conducted over time by a given researcher, in different laboratories, by different researchers, and in different countries. In this paper, terms are applied systematically in an hierarchical flow chart to enable classification of individual animals. We propose descriptive terms for different stages in the pathogenesis of paratuberculosis to enable their use in different types of studies and to enable an independent assessment of the extent to which accepted definitions for stages of disease have been applied consistently in any given study. This will assist in the general interpretation of data between studies, and will facilitate future meta-analyses.

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Section: Characteristics Of Diagnostic Tests For Paratuberculosismentioning

confidence: 99%

“…2 ). Gross lesions are not specific for paratuberculosis and may be absent [ 76 ]. There is an ambiguous category where exposure occurred, microscopic lesions are present but the organisms cannot be demonstrated; this category includes recovered cases.…”

Section: Definitions Of Termsmentioning

confidence: 99%

Case definition terminology for paratuberculosis (Johne’s disease)

et al. 2017

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“…Data collected from lines of slaughter sheep are used to assess national and regional animal health status and to provide farmers with feedback in order to inform both proactive animal health planning and reduce the effects of endemic disease on flock productivity and profitability . NSHMP abattoir surveillance data have previously been used to estimate the prevalence of ovine paratuberculosis and caseous lymphadenitis . Other monitored conditions include sarcosporidiosis (caused by Sarcocystis spp.…”

mentioning

confidence: 99%

Abattoir surveillance of Sarcocystis spp., Cysticercosis ovis and Echinococcus granulosus in Tasmanian slaughter sheep, 2007–2013

Phythian

Jackson²,

Bell³

et al. 2018

Aust Veterinary J

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Reasons for the significant between-abattoir differences in recorded levels of ovine sarcosporidiosis and cysticercosis remain unknown, but may represent sampling bias, with subsets of slaughter sheep going to abattoirs with different tiers or access to markets. Further investigation into apparent differences, including epidemiological studies of properties with high lesion prevalence, comparing meat inspector diagnostic sensitivity, assessing the effect of line speed and tiers and market access in different abattoirs, may be useful.

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“…Over several decades there have been many studies which have observed the effectiveness of meat inspection protocols in discovering diseases in slaughter animal populations. These studies have shown that the sensitivity (the ability to detect true positive cases) of the inspection process to detect diseases and conditions increases when their prevalence increases (Mousing et al, 1997 andAbbott andWhitingdon, 2003). The sensitivity of meat inspection procedures is highly variable depending upon both disease and abattoir factors.…”

Section: Introduction and Objectivesmentioning

confidence: 99%