Monte Carlo simulations and experimental studies of yttrium-90 production using a 33MeV linac

Necsoiu, D.; Morgan, I.L.; Hupf, H.B.; Courtney, W. J.; Kinross-Wright, J.; Bouanani, M. El; Duggan, J.L.; McDaniel, F. D.

doi:10.1016/s0969-8043(02)00125-2

Cited by 3 publications

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“…O desenvolvimento da Medicina Nuclear levou a um aumento na demanda da produção de radioisótopos, com propriedades físicas e químicas adequadas para uma variedade de tratamentos (NECSOIU et. al, 2002).…”

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Desenvolvimento de tecnologias de preparo de geradores de 90Sr/90Y na Diretoria de Radiofarmácia do IPEN/CNEN-SP

Barrio¹

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Y (T ଵ/ଶ = 2,67 d; E β୫á୶ = 2,28 MeV) is a radionuclide with efficacy established for various cancer therapies, labeling biomolecules and treating of radiosinovectomy. Due to its nuclear properties, is obtained through the decay of 90 Sr T ଵ/ଶ = 28 y in the form of a generator. Several types of 90 Sr/ 90 Y generators were developed, and the most employed are the cation exchange resins, where Sr and Y are adsorbed and 90 Y is selectively eluted with acetate or EDTA. The disadvantage of this type of generator is the radiolysis, which degrades its use. The electrochemical generator is a proposed solution because there is no significant effect of radiation. In this concept, the difference between the electrochemical potentials of the elements Sr and Y is used to obtain a rapid separation of 90 Y from 90 Sr. The production of 90 Y via colloid formation is the simplest method for the separation, based on the colloid formation of Y in high alkaline pH, which can be filtered and separated from Sr, and subsequently dissolved in HCl. The objective of this work was the development of technologies for the preparation of 90 Sr/ 90 Y generators, and three technologies were developed: generators using cation resins columns, generators through colloid formation and electrochemical generators. Radionuclidic quality control of 90 Y was also evaluated by liquid scintillation, radionuclide identity, extraction paper chromatography (EPC) using complexing agents for 90 Y and by Optical Emission Spectrometry with Inductively Coupled Plasma (ICP-OES). The results showed that generators using cation resins have the best results related to the elution efficiency (~83%), the reproducibility and radionuclidic purity. The electrochemical generator showed a potential for development, having the advantage of not suffering the effects of radiolysis of the pair 90 Sr/ 90 Y as the resin. A comparison and evaluation of the methods of the radionuclidic quality control showed that the EPC is very sensitive and allows for virtually instantaneous assessment of the quality of 90 Y generator.

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Section: Introdução E Justificativaunclassified

“…al, 1993). As especificações da forma do produto dita que a pureza radionuclídica de 90 Y em relação a 90 Sr deve ser de até 92,5 kBq (2,5 µCi) 90 Sr/Ci 90 Y (NECSOIU et. al, 2002).…”

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Desenvolvimento de tecnologias de preparo de geradores de 90Sr/90Y na Diretoria de Radiofarmácia do IPEN/CNEN-SP

Barrio¹

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Prediction of 94mTc production for positron emission tomography studies using the Monte Carlo code MCNPX-2.6

Sadeghi

Hashemi

Afarideh

et al. 2013

Applied Radiation and Isotopes

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Jerome Lewis Duggan: A Nuclear Physicist and a Well-Known, Six-Decade Accelerator Application Conference (CAARI) Organizer

McDaniel

Doyle

2016

Rev. Accl. Sci. Tech.

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Jerry Duggan was an experimental MeV-accelerator-based nuclear and atomic physicist who, over the past few decades, played a key role in the important transition of this field from basic to applied physics. His fascination for and application of particle accelerators spanned almost 60 years, and led to important discoveries in the following fields: accelerator-based analysis (accelerator mass spectrometry, ion beam techniques, nuclear-based analysis, nuclear microprobes, neutron techniques); accelerator facilities, stewardship, and technology development; accelerator applications (industrial, medical, security and defense, and teaching with accelerators); applied research with accelerators (advanced synthesis and modification, radiation effects, nanosciences and technology); physics research (atomic and molecular physics, and nuclear physics); and many other areas and applications. Here we describe Jerry’s physics education at the University of North Texas (B. S. and M. S.) and Louisiana State University (Ph.D.). We also discuss his research at UNT, LSU, and Oak Ridge National Laboratory, his involvement with the industrial aspects of accelerators, and his impact on many graduate students, colleagues at UNT and other universities, national laboratories, and industry and acquaintances around the world. Along the way, we found it hard not to also talk about his love of family, sports, fishing, and other recreational activities. While these were significant accomplishments in his life, Jerry will be most remembered for his insight in starting and his industry in maintaining and growing what became one of the most diverse accelerator conferences in the world — the International Conference on the Application of Accelerators in Research and Industry, or what we all know as CAARI. Through this conference, which he ran almost single-handed for decades, Jerry came to know, and became well known by, literally thousands of atomic and nuclear physicists, accelerator engineers and vendors, medical doctors, cultural heritage experts... the list goes on and on. While thousands of his acquaintances already miss Jerry, this is being felt most by his family and us (B.D. and F.D.M).

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Monte Carlo simulations and experimental studies of yttrium-90 production using a 33MeV linac

Cited by 3 publications

References 13 publications

Desenvolvimento de tecnologias de preparo de geradores de 90Sr/90Y na Diretoria de Radiofarmácia do IPEN/CNEN-SP

Desenvolvimento de tecnologias de preparo de geradores de 90Sr/90Y na Diretoria de Radiofarmácia do IPEN/CNEN-SP

Prediction of 94mTc production for positron emission tomography studies using the Monte Carlo code MCNPX-2.6

Jerome Lewis Duggan: A Nuclear Physicist and a Well-Known, Six-Decade Accelerator Application Conference (CAARI) Organizer

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