Montmorillonite Clay-Based Polyurethane Nanocomposite As Local Triamcinolone Acetonide Delivery System

Pinto, Flávia Carmo Horta; Silva-Cunha, Armando; Pianetti, Gérson Antônio; Ayres, Eliane; Oréfice, Rodrigo Lambert; Silva, Gisele Rodrigues da

doi:10.1155/2011/528628

Cited by 27 publications

(13 citation statements)

References 45 publications

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“…It was observed that approximately 40% of MTX was released from PCL implants in vitro and 95% of drug was delivered by PCL implants in vivo during 18 d. The differences between the physiological environment (in vivo test) and the simulated physiological conditions (in vitro test) explain the lack of correlation between the in vivo and in vitro profile release of MTX from PCL implants (Pinto et al, 2011). Figure 8 shows the cytotoxicity of the solution of PCL implants (without drug) against HeLa cells.…”

Section: In Vivo Release Of Mtx From the Pcl Implantsmentioning

confidence: 99%

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice

Pereira

Barbosa

et al. 2013

Drug Delivery

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Context: Methotrexate (MTX) is used in the treatment of malignancies; however, its clinical application is limited by its toxic dose-related side effects. An alternative to overcome the toxicity of the MTX in healthy tissues is the design of an implantable device capable of controlling the delivery of this drug for an extended period within the tumor site. Objective: To develop methotrexate-loaded poly("-caprolactone) implants (MTX PCL implants) and to demonstrate their efficacy as local drug delivery systems capable of inhibiting Ehrlich solid tumor bearing mice. Materials and methods: MTX PCL implants were produced by the melt-molding technique and were characterized by FTIR, WAXS, DSC and SEM. The in vitro and in vivo release of MTX from the PCL implants was also evaluated. The efficacy of implants in inhibiting tumor cells in culture and the solid tumor in a murine model was revealed. Results and discussion: The chemical and morphological integrity of the drug was preserved into the polymeric matrix. The in vitro and in vivo release processes of the MTX from the PCL implants were modulated by diffusion. MTX diffused from the implants revealed an antiproliferative effect on tumor cells. Finally, MTX controlled and sustained released from the polymeric implants efficiently reduced 42.7% of the solid tumor in mice paw. Conclusion: These implantable devices represented a contribution to improve the efficacy and safety of chemotherapy treatments, promoting long-term local drug accumulation in the targeted site.

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Section: In Vivo Release Of Mtx From the Pcl Implantsmentioning

confidence: 99%

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice

Pereira

Barbosa

et al. 2013

Drug Delivery

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“…Alternatively, the minimum units of clay can also be dispersed into the polymer matrix, with marked increase in interaction between the two, producing a material with different characteristics to the parent constituents (21). These are referred to as intercalated and exfoliated systems, respectively.…”

Section: Clay and Polymer-based Composites Applied As Drug Carriersmentioning

confidence: 99%

“…The main drugs carried in the articles analysed were non-steroidal anti-inflammatory drugs (46.1%) (24,39,40,(66)(67)(68), antimicrobial (25.6%) (21,34,65,69,74) and chemotherapeutic agents (10.3%) (13,14). This distribution can be explained by the adverse events associated with the use of these active principles, whether due to the reduction in gastric protection resulting from prolonged use of the anti-inflammatory drugs and analgesics, or to the intrinsic toxicity of chemotherapeutic agents and some antimicrobials associated with the risk of resistance (75,76).…”

Section: Clay and Polymer-based Composites Applied As Drug Carriersmentioning

confidence: 99%

“…A host of different constituents were used in the polymeric part of these hybrid materials, ranging from chitosan (14,28,36-38,56,72), alginate (51,62,71), guar gum (22) and hyaluronic acid (72), to synthetic polyvinyl alcohol (48,49), poly (lactic-co-glycolic acid) (32,57,69), polyurethane (4,6,21,34,35), and poly(L-lactic acid) (5,8,63), among others. These polymers were employed predominantly as matrices (22,26,32,35,49,66,74,89), but in some cases formed the composite coating (64,70,71).…”

Section: Polymersmentioning

confidence: 99%

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Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Meirelles

Raffin

2017

J Pharm Pharm Sci

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-There has been a growing trend in recent years for the development of hybrid materials, called composites, based on clay and polymers, whose innovative properties render them attractive for drug release. The objective of this manuscript was to conduct a review of original articles on this topic published over the last decade and of the body of patents related to these carriers. A scientific prospection was carried out spanning the period from 2005 to 2015 on the Web of Science database. The technological prospection encompassed the United States Patent and Trademark Office, the European Patent Office, the World International Patent Office and the National Institute of Industrial Property databases, filtering patents with the code A61K. The survey revealed a rise in the number of publications over the past decade, confirming the potential of these hybrids for use in pharmaceutical technology. Through interaction between polymer and clay, the mechanical and thermal properties of composites are enhanced, promoting stable, controlled drugs release in biological media. The most cited clays analyzed in the articles was montmorillonite, owing to its high surface area and capacity for ion exchange. The polymeric part is commonly obtained by copolymerization, particularly using acrylate derivatives. The hybrid materials are obtained mainly in particulate form on a nanometric scale, attaining a modified release profile often sensitive to stimuli in the media. A low number of patents related to the topic were found. The World International Patent Office had the highest number of lodged patents, while Japan was the country which published the most patents. A need to broaden the application of this technology to include more therapeutic classes was identified. Moreover, the absence of regulation of nanomaterials might explain the disparity between scientific and technological output.

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“…Contemporaneously, researchers have been interested in the investigation of the intercalation reactions (IRs) that involves kaolinite layered phyllosilicates for the purpose of scientific and technological advancements in the areas of catalysis; water filtration; composites; nanotechnology; controlled released formulations [1,2] such as drug delivery systems (DDSs) and controlled release fertilizers (CRFs) [3][4][5][6][7][8][9][10]. Progressive application of kaolinite in the engineering designs has been practically feasible owing to the fact that kaolinite (which is an inexpensive chemical mineral) can be modified through ion exchange mechanisms by just intercalation of ionic species into the kaolinite interlayer spaces.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Kaolinite-Urea Nanocomposites via Coupled DMSO-Hydroxyaluminum Oligomeric Intermediates

Sempeho

Kim

Mubofu

et al. 2015

Indian Journal of Materials Science

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Kaolinite-urea nanocomposites were prepared via intercalation reactions in an attempt to investigate the dynamic nature of kaolinite morphology for advanced applications in controlled release systems (CRS). Characterization was done using SEM-EDX, XRF, ATR-FTIR, XRD, and DT/DTG; Andreasen pipette sedimentation technique was used to determine the grain size distribution of the raw kaolinite. The X-ray diffraction pattern revealed the existence of an FCC Bravais lattice where the intercalation ratios attained were 51.2%, 32.4%, 7.0%, and 38.4% for hydroxyaluminum oligomeric intercalated kaolinite, substituted urea intercalated kaolinite, calcined DMSO intercalated kaolinite, and hydroxyaluminum reintercalated kaolinite, respectively, along with their respective crystallite sizes of 33.51-31.73 nm, 41.92-39.69 nm, 22.31-21.13 nm, and 41.86-39.63 nm. The outcomes demonstrated that the employed intercalation routes require improvements as the intercalation reactions were in average only ≈32.3%. The observations unveiled that it is possible to manipulate kaolinite structure into various morphologies including dense-tightly packed overlapping euhedral pseudo hexagonal platelets, stacked vermiform morphologies, postulated forms, and unique patterns exhibiting self-assembled curled glomeruli-like morphologies. Such a diversity of kaolinite morphologies expedites its advanced applications in the controlled release systems (CRS) such as drug delivery systems and controlled release fertilizers (CRFs).

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Montmorillonite Clay-Based Polyurethane Nanocomposite As Local Triamcinolone Acetonide Delivery System

Cited by 27 publications

References 45 publications

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Dynamics of Kaolinite-Urea Nanocomposites via Coupled DMSO-Hydroxyaluminum Oligomeric Intermediates

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