Montmorillonite/poly-(ε-caprolactone) composites as versatile layered material: Reservoirs for anticancer drug and controlled release property

Kevadiya, Bhavesh D.; Thumbar, Rahul P.; Rajput, Mahendrapalsingh M.; Rajkumar, Shalini; Brambhatt, Harshad; Joshi, Ghanshyam V.; Dangi, Ganga P.; Mody, Haresh M.; Gadhia, Pankaj; Bajaj, Hari C.

doi:10.1016/j.ejps.2012.04.009

Cited by 54 publications

(24 citation statements)

References 27 publications

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“…In recent years, a drug carrier of choice has been the family of layered silicates with Mt structure. For example, experiments have been performed on the delivery of the following substances: anticancer drugs (5-fluorouracil (Lin et al, 2002), paclitaxel (Dong and Feng, 2005), tamoxefin (Kevadiya et al, 2012), citostatic drugs (Iliescu et al, 2011)), nonsteroidal anti-inflammatory drugs (ibuprofen (Zheng et al, 2007) and phenyl salicylate (Hoyo et al, 1996)), antibiotics (metronidazole (Calabrese et al, 2013)), anaesthetic drugs (Kevadiya et al, 2011), antihistaminic drugs (promethazine (Seki and Kadir, 2006)), indispensable amino acids (histidine, methionine, lysine, tryptophan, and glycine) (Kollar et al, 2003), and antidepressants (amitriptyline (Chang et. al, 2014)).…”

Section: Introductionmentioning

confidence: 99%

Adsorption and in vitro release of vitamin B1 by synthetic nanoclays with montmorillonite structure

Golubeva

Pavlova

Yakovlev

2015

Applied Clay Science

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Section: Introductionmentioning

confidence: 99%

Adsorption and in vitro release of vitamin B1 by synthetic nanoclays with montmorillonite structure

Golubeva

Pavlova

Yakovlev

2015

Applied Clay Science

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“…Functionalization with organic modifiers via an ion exchange reaction confers montmorillonite increased basal spacing and separation between its platelets [4,12] as well as better mixing ability, and facilitates its interactions with hydrophobic polymers [3,4,13] . Complementary, its high aspect ratio [5] ensures better reinforcement within the polymeric plane itself [14] by enhancing polymer’s properties at a fairly low silicate content [13] and leading to the formation of nanoclay-polymer-based composites with increased mechanical strength [3,14], barrier properties [3,15], UV dispersion [15], and fire resistance capabilities [3,16], to be used for food packaging [17,18], automotive [19,20], medical devices [21,22], and for coatings-related applications [23,24]. …”

Section: Introductionmentioning

confidence: 99%

Toxicity evaluations of nanoclays and thermally degraded byproducts through spectroscopical and microscopical approaches

Wagner

Eldawud

White

et al. 2017

Biochimica et Biophysica Acta (BBA) - General Subjects

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Background Montmorillonite is a type of nanoclay that originates from the clay fraction of the soil and is incorporated into polymers to form nanocomposites with enhanced mechanical strength, barrier, and flammability properties used for food packaging, automotive, and medical devices. However, with implementation in such consumer applications, the interaction of montmorillonite-based composites or derived byproducts with biological systems needs to be investigated. Methods Herein we examined the potential of Cloisite Na+ (pristine) and Cloisite 30B (organically modified montmorillonite nanoclay) and their thermally degraded byproducts’ to induce toxicity in model human lung epithelial cells. The experimental set-up mimicked biological exposure in manufacturing and disposal areas and employed cellular treatments with occupationally relevant doses of nanoclays previously characterized using spectroscopical and microscopical approaches. For nanoclay-cellular interactions and for cellular analyses respectively, biosensorial-based analytical platforms were used, with induced cellular changes being confirmed via live cell counts, viability assays, and cell imaging. Results Our analysis of byproducts’ chemical and physical properties revealed both structural and functional changes. Real-time high throughput analyses of exposed cellular systems confirmed that nanoclay induced significant toxic effects, with Cloisite 30B showing time-dependent decreases in live cell count and cellular viability relative to control and pristine nanoclay, respectively. Byproducts produced less toxic effects; all treatments caused alterations in the cell morphology upon exposure. Conclusions Our morphological, behavioral, and viability cellular changes show that nanoclays have the potential to produce toxic effects when used both in manufacturing or disposal environments. General significance The reported toxicological mechanisms prove the extensibility of a biosensorial-based platform for cellular behavior analysis upon treatment with a variety of nanomaterials.

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“…A survey of the literature reveals that the PCL/MMT nanocomposite has been employed in drug delivery systems [13][14][15], but it appears that its use for improved delivery of curcumin is yet to be explored. Therefore, the aim of this study is to formulate curcumin-loaded PCL/organoclay (modified with n-cetyl-N,N,N,-trimethylammonium bromide, a cationic surfactant) nanoparticles to improve its therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Study of Drug Release Properties of Curcumin from Polycaprolactone /Organomodified Montmorillonite Nanocomposite

2016

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Purpose This study aims to intercalate polycaprolactone (PCL)/curcumin nanocomposite in the interlayer spaces of montmorillonite clay (MMT) modified with n-cetyl-N,N,Ntrimethylammonium bromide (CTAB) for improved drug release. Methods Curcumin-loaded polycaprolactone/organoclay nanoparticles prepared by nanoprecipitation method were characterized by determining the size, zeta potentials, and encapsulation efficiency. Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) measurements of the nanoparticles were performed. The data obtained from in vitro drug release studies were fitted into different drug release models, and the mechanism of drug release was determined. Results Result shows that the curcumin nanoparticles are round, discrete, and smooth in surface morphology, within the 155-206.5-nm size range, and have fairly low polydispersity index (≤0.37). Formulations containing MMT have higher encapsulation efficiency and drug loading than formulations without MMT. DSC analysis suggests no potential interaction between the components of the nanoparticles. Analysis of the in vitro data reveals that the power law best describes the release mechanism and suggests a non-Fickian swelling-controlled drug release. An initial burst of 60-75 % release was found at the sixth hour in the formulations and then a more sustained release afterwards. Formulations with higher MMT concentration showed slower drug release when compared with formulations with lower MMT concentration. Conclusion This study suggests that the incorporation of curcumin into PCL/CTAB-MMT nanoparticles could result in improved drug release and also provided an effective way to further improve the antitumor activity of curcumin through the nanodrug delivery system.

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Montmorillonite/poly-(ε-caprolactone) composites as versatile layered material: Reservoirs for anticancer drug and controlled release property

Cited by 54 publications

References 27 publications

Adsorption and in vitro release of vitamin B1 by synthetic nanoclays with montmorillonite structure

Adsorption and in vitro release of vitamin B1 by synthetic nanoclays with montmorillonite structure

Toxicity evaluations of nanoclays and thermally degraded byproducts through spectroscopical and microscopical approaches

Synthesis, Characterization, and Study of Drug Release Properties of Curcumin from Polycaprolactone /Organomodified Montmorillonite Nanocomposite

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