Mood and behavior regulation: interaction of lithium and dopaminergic system

Mohamadian, Marjan; Fallah, Hamed; Ghofrani-Jahromi, Zahra; Rahimi-Danesh, Mehrsa; Saadlou, Mohammad-Saleh Shokouhi Qare; Vaseghi, Salar

doi:10.1007/s00210-023-02437-1

Cited by 10 publications

(6 citation statements)

References 258 publications

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“…Dopamine neurotransmission has previously been associated with response to lithium treatment in BD 45 .…”

Section: Discussionmentioning

confidence: 99%

Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study

Kelsoe,

Ou,

Rosenthal

et al. 2023

Preprint

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Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.

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“…Dopamine neurotransmission has previously been associated with response to lithium treatment in BD 45 .…”

Section: Discussionmentioning

confidence: 99%

Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study

Kelsoe,

Ou,

Rosenthal

et al. 2023

Preprint

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“…The mesocortical pathway, which originates from VTA and projects to the frontal cortex and septohippocampal regions, modulates cognitive and emotional behavior and processes. It also describes its associated with the glutamatergic pathway [36][37][38]. The tubero-infundibular pathway, in which fibers originate from the hypothalamus (arcuate and paraventricular nuclei) and project to the median eminence of the pituitary gland, is related to the lactation phenomenon via prolactin inhibition [39,40].…”

Section: The Dopamine Systemmentioning

confidence: 99%

Dopamine Pharmacodynamics: New Insights

Lauretani,

Giallauria,

Testa

et al. 2024

IJMS

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Dopamine is a key neurotransmitter involved in physiological processes such as motor control, motivation, reward, cognitive function, and maternal and reproductive behaviors. Therefore, dysfunctions of the dopaminergic system are related to a plethora of human diseases. Dopamine, via different circuitries implicated in compulsive behavior, reward, and habit formation, also represents a key player in substance use disorder and the formation and perpetuation of mechanisms leading to addiction. Here, we propose dopamine as a model not only of neurotransmission but also of neuromodulation capable of modifying neuronal architecture. Abuse of substances like methamphetamine, cocaine, and alcohol and their consumption over time can induce changes in neuronal activities. These modifications lead to synaptic plasticity and finally to morphological and functional changes, starting from maladaptive neuro-modulation and ending in neurodegeneration.

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“…Although dopaminergic neurons extend a widespread network into the adult forebrain, they are localized to only a few distinct clusters in the olfactory bulb, hypothalamus, and, most importantly, in the mesencephalon [141][142][143]. In the latter structure, dopaminergic neurons are found in the substantia nigra pars compacta, an area that projects to the striatum (neostriatal pathway), as well as in the ventral tegmental area (VTA), which projects to the cerebral cortex and limbic structures (mesocortical and mesolimbic pathways, respectively).…”

Section: Th and The Dopaminergic Systemmentioning

confidence: 99%

“…In the latter structure, dopaminergic neurons are found in the substantia nigra pars compacta, an area that projects to the striatum (neostriatal pathway), as well as in the ventral tegmental area (VTA), which projects to the cerebral cortex and limbic structures (mesocortical and mesolimbic pathways, respectively). Dopaminergic neurons have been implicated in the control of movement, cognition, mood, and behavior, as well as in multiple neurological disorders, such as Parkinson disease, schizophrenia, or attention deficit hyperactivity disorder (ADHD) [143]. Biochemically, the neuromodulator dopamine is synthesized from tyrosine via the intermediate DOPA in a two-step reaction catalyzed by tyrosine hydroxylase and DOPA decarboxylase.…”

Section: Th and The Dopaminergic Systemmentioning

confidence: 99%

Local Thyroid Hormone Action in Brain Development

Martin

Mayerl

2023

IJMS

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Proper brain development essentially depends on the timed availability of sufficient amounts of thyroid hormone (TH). This, in turn, necessitates a tightly regulated expression of TH signaling components such as TH transporters, deiodinases, and TH receptors in a brain region- and cell-specific manner from early developmental stages onwards. Abnormal TH levels during critical stages, as well as mutations in TH signaling components that alter the global and/or local thyroidal state, result in detrimental consequences for brain development and neurological functions that involve alterations in central neurotransmitter systems. Thus, the question as to how TH signaling is implicated in the development and maturation of different neurotransmitter and neuromodulator systems has gained increasing attention. In this review, we first summarize the current knowledge on the regulation of TH signaling components during brain development. We then present recent advances in our understanding on how altered TH signaling compromises the development of cortical glutamatergic neurons, inhibitory GABAergic interneurons, cholinergic and dopaminergic neurons. Thereby, we highlight novel mechanistic insights and point out open questions in this evolving research field.

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Mood and behavior regulation: interaction of lithium and dopaminergic system

Cited by 10 publications

References 258 publications

Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study

Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study

Dopamine Pharmacodynamics: New Insights

Local Thyroid Hormone Action in Brain Development

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