Mood disorders are associated with the reduction of brain derived neurotrophic factor in the hypocampus in rats submitted to the hipercaloric diet

Malheiros, Rafael Soares Pozzi; Delgado, Helena Oliveira; Felber, Daniel Tassinari; Kraus, Scheila Iria; Santos, Adair R.S.; Manfredini, Vanusa; Silva, Morgana Duarte da

doi:10.1007/s11011-020-00625-z

Cited by 9 publications

(6 citation statements)

References 43 publications

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“…BDNF in the adult brain has been found to be involved in synaptic transmission processes and synaptic plasticity that aid cognitive function [ 52 ]. In this study, brain BDNF levels decreased following 16 weeks HCHF diet supplementation, which is in line with the results of a previous study [ 53 ]. Previously, we found that diabetic patients and patients with glycemic disorders had lower BDNF concentrations than healthy subjects [ 54 ].…”

Section: Discussionsupporting

confidence: 93%

Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain

et al. 2022

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There is mounting evidence that metabolic syndrome (MetS) contributes to the development of neurodegenerative disorders such as Alzheimer’s disease. Honey, which has been used for generations, is high in antioxidants and has been demonstrated to benefit the brain and mental health by reducing oxidative stress and boosting cognitive outcomes. Honey from the stingless bees of Heterotrigona itama has been found to have higher phenolic content compared to other types of honeys. The aim of this study is to investigate the effects of stingless bee honey (SBH) supplementation and to compare it with a pure form of antioxidant, caffeic acid (CA), on MetS parameters and inflammatory markers in the brains of MetS-induced rats. A total of 32 male Wistar rats were divided equally into groups of control, high-carbohydrate high-fructose (HCHF) diet (MetS), HCHF + SBH supplemented (1 g/kg) (SBH), and HCHF + CA supplemented (10 mg/kg) (CA) groups. The total duration for SBH and CA supplementation was eight weeks. The HCHF diet was found to promote hypertension, hyperglycemia, and hypertriglyceridemia, and to increase brain TNF-α levels. Supplementation with SBH and CA significantly reversed (p < 0.05) the hyperglycemic and hypertensive effects of the HCHF diet. Although both supplemented groups showed no significant changes to serum HDL or TG, SBH significantly reduced (p < 0.05) brain TNF-α levels and increased (p < 0.05) brain BDNF levels. Immunohistochemistry investigations of neurogenesis (EdU) and apoptosis (TUNEL) on the cornu Ammonis 1 (CA1) and dentate gyrus (DG) areas of the hippocampus showed no changes with SBH and CA supplementation compared to the control. These findings suggest that SBH and CA have the potential to mitigate HCHF-induced MetS effects and possess neuroprotective abilities.

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Section: Discussionsupporting

confidence: 93%

Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain

et al. 2022

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“…As previously reported BDNF levels and plasma declined with advancing age [33]. Similarly, another study [34] reported that low BDNF levels were related with diabetes mellitus and elevated LDL levels.…”

Section: Discussionsupporting

confidence: 52%

Association of Serum Level and DNA Methylation Status of Brain-Derived Neurotrophic Factor with the Severity of Coronary Artery Disease

Batool¹,

Sarfraz²,

Raza³

et al. 2023

PJMHS

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Background and Aim: Brain-derived neurotrophic factor (BDNF) has shown to promote myelination besides its effect on survival, differentiation, and plasticity of neurons. It has an important role in maintaining cardiovascular health in addition to its central nervous system function. The present study aimed to determine the serum level association with DNA Methylation status of brain derived neurotrophic factor with severity of coronary artery disease. Methods: This cross-sectional study was carried out on 164 major coronary artery patients in the department of Biochemistry & Pharmacology of Bahawal Victoria Hospital Bahawalpur from April 2022 to December 2022. Individual with possible cardiac symptoms such as chest pain and dyspnea were enrolled. Patients were distributed as CAD group (n=82) and non-CAD group (n=82). CAD severity was measured by Gensini scoring system. The coronary artery lumen stenosis was defined as follows: 1, 2, 4, 8, 16, and 32 was for 1-25%, 26-50%, 51-75%, 76-90%, 91-99%, and total occlusion respectively. Prior to angiography, patients’ anthropometric parameters such as BMI, systolic, and diastolic pressure were recorded. Demographic details such as age, gender, and smoking status were also noted. SPSS version 27 was used for data analysis. Results: Of the total 164 patients, there were 82 study group comprised of 58 (70.7%) male and 24 (29.3%) females whereas control group was comprised of 40 (48.8%) male and 42 (51.2%) females. Study group had at least one major coronary artery with > 50% stenosis classified as CAD group and non-CAD group patients had completely normal coronary angiographies. The CAD group patients had higher mean age and smokers than non-CAD group. The incidence of hypermethylated BDNF gene in CAD and non-CAD group was 86.6% and 70.7% respectively. There were insignificance difference of serum BDNF concentration mean values in CAD group (1.82 [1.61-2.12] ng/ml) versus non-CAD group (1.69 [1.39-2.03]). The BDNF methylation was found 81.2% in male and 83.4% in female patients. Regarding serum BDNF mean value, no significance difference was observed in men (1.82 [1.52–2.12]) and women (1.70 [1.44–2.02]). Conclusion: The present study concluded that the increased risk of CAD associated with BDNF hypermethylation may be useful for identifying subjects at risk. A significant correlation was also found between BDNF hypermethylation and CAD severity. There was no significant association between severity of CAD and BDNF serum level. Keywords: Brain-derived neurotrophic factor, serum level, Coronary artery disease, Severity, DNA methylation

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“…BDNF also plays an important role in fat accumulation in an animal model, since young rats under a hypercaloric diet showed an increase in adipose tissue concentration, and this was associated with reduced hippocampal BDNF expression [ 22 ]. Our results at baseline are in accordance with these findings, shown by the positive correlation we found between mean methylation in adipose tissue and waist/hip ratio, and the negative correlation between serum levels and waist/hip ratio, since if the methylation levels are high, we would expect lower BDNF expression accompanied by higher waist/hip ratio.…”

Section: Discussionmentioning

confidence: 99%

Methylation Status of Exon IV of the Brain-Derived Neurotrophic Factor (BDNF)-Encoding Gene in Patients with Non-Diabetic Hyperglycaemia (NDH) before and after a Lifestyle Intervention

et al. 2022

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BDNF signalling in hypothalamic neuronal circuits is thought to regulate mammalian food intake. In light of this, we investigated how a lifestyle intervention influenced serum levels and DNA methylation of BDNF gene in fat tissue and buffy coat of NDH individuals. In total, 20 participants underwent anthropometric measurements/fasting blood tests and adipose tissue biopsy pre-/post-lifestyle (6 months) intervention. DNA was extracted from adipose tissue and buffy coat, bisulphite converted, and pyrosequencing was used to determine methylation levels in exon IV of the BDNF gene. RNA was extracted from buffy coat for gene expression analysis and serum BDNF levels were measured by ELISA. No differences were found in BDNF serum levels, but buffy coat mean BDNF gene methylation decreased post-intervention. There were correlations between BDNF serum levels and/or methylation and cardiometabolic markers. (i) Pre-intervention: for BDNF methylation, we found positive correlations between mean methylation in fat tissue and waist-hip ratio, and negative correlations between mean methylation in buffy coat and weight. (ii) Post-intervention: we found correlations between BDNF mean methylation in buffy coat and HbA1c, BDNF methylation in buffy coat and circulating IGFBP-2, and BDNF serum and insulin. Higher BDNF % methylation levels are known to reduce BNDF expression. The fall in buffy coat mean BDNF methylation plus the association between lower BDNF methylation (so potentially higher BDNF) and higher HbA1c and serum IGFBP-2 (as a marker of insulin sensitivity) and between lower serum BDNF and higher circulating insulin are evidence for the degree of BDNF gene methylation being implicated in insulinisation and glucose homeostasis, particularly after lifestyle change in NDH individuals.

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Mood disorders are associated with the reduction of brain derived neurotrophic factor in the hypocampus in rats submitted to the hipercaloric diet

Cited by 9 publications

References 43 publications

Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain

Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain

Association of Serum Level and DNA Methylation Status of Brain-Derived Neurotrophic Factor with the Severity of Coronary Artery Disease

Methylation Status of Exon IV of the Brain-Derived Neurotrophic Factor (BDNF)-Encoding Gene in Patients with Non-Diabetic Hyperglycaemia (NDH) before and after a Lifestyle Intervention

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