Mood Disorders: The Gut Bacteriome and Beyond

McGuinness, Amelia J.; Loughman, Amy; Foster, Jane A.; Jacka, Felice

doi:10.1016/j.biopsych.2023.08.020

Cited by 8 publications

(4 citation statements)

References 139 publications

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“…In addition to zinc, this patient increased their intake of fermented foods after antibiotic cessation. Emerging evidence suggests fermented foods may have important antimicrobial and immune-modulating benefits [54][55][56][57]. Increased fermented food consumption in this case could potentially have conferred additional antimicrobial benefits, possibly through supporting a microbiota environment less hospitable to future GAS involvement.…”

Section: Gut Health and Strep Susceptibilitymentioning

confidence: 90%

Sudden-Onset Acute Obsessive-Compulsive Disorder Associated with Streptococcus and Brain MRI Hyperintensity in a Young Adult

Jory,

Handelman

2024

Healthcare

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Background: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal (strep) infections (PANDAS) are a recognized medical entity among children. But evidence for strep-mediated sudden-onset obsessive–compulsive disorder (OCD) in young adults is very limited. Delayed strep assessment and treatment may negatively impact clinical outcomes. Methods: We describe a young adult with acute sudden-onset OCD (age 24), treated unsuccessfully with medication and therapy for 3 years. At age 27, antistreptolysin-O (ASO) was tested, based on extensive pediatric history of strep infections. Antibiotic treatment was initiated. Results: Magnetic resonance imaging (MRI) identified a new temporal lobe hyperintensity at OCD onset (age 24), which persisted at ages 25 and 30. ASO titers were elevated from age 27 through 29. Following Amoxicillin treatment, ASO initially increased. Subsequent Amoxicillin + Clavulin treatment produced improved OCD symptoms and treatment response, with no adverse effects. Conclusion: These results strongly suggest an association among strep infection, neuro-inflammation and sudden-onset OCD in this young adult whose response to medication and therapy was successful only after high-dose antibiotic intervention. Greater OCD remission potential may be possible with earlier identification and antibiotic treatment than 3 years post OCD onset. These findings add to the limited literature on strep as an etiology of the sudden-onset of OCD in young adults. They also lend urgency to increased frontline awareness for early strep and ASO assessment in sudden-onset acute OCD among young adults.

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Section: Gut Health and Strep Susceptibilitymentioning

confidence: 90%

Sudden-Onset Acute Obsessive-Compulsive Disorder Associated with Streptococcus and Brain MRI Hyperintensity in a Young Adult

Jory,

Handelman

2024

Healthcare

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“…Žarnyno mikrobiota yra sudėtingas virusų, pirmuonių, archėjų, grybų, parazitų ir bakterijų rinkinys [1]. Pastarosios labai svarbios daliai fiziologinių procesų ir yra susijusios su asmens sveikata ir ligomis.…”

Section: įVadasunclassified

Žarnyno Ir Smegenų Ašies Reikšmė Psichiatrijai

Dūdonytė

2024

Health Sciences

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Žarnyno mikrobiota – bakterijų, virusų, pirmuonių, archėjų, grybų ir parazitų rinkinys. Mokslininkams vis labiau domintis mikrobiotos svarba pacientų sveikatai, pastebėta, jog ji turi įtakos CNS vystymuisi, asmens psichinei būsenai per imuninius, endokrininius ir nervinius mechanizmus − stebimas sisteminis uždegimas, pakinta neuromediatorių ir neuromoduliatorių kiekiai. Dažniausiai literatūroje apžvelgiamos žarnyno mikrobiotos ir depresijos, autizmo, obsesinio kompulsinio sindromo, šizofrenijos sąsajos, stebimos bakterijų translokacijos, kurios koreliuoja su psichiatrinių sutrikimų simptomų atsiradimu ar jų sustiprėjimu.

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“…These fermentation products include, for example, vitamins (such as B vitamins), bioactive peptides (such as lactotripeptides), bacteriocins (which aid with bacterial survival), short-chain fatty acids (such as butyric acid), and neurotransmitters (such as GABA [gamma-aminobutyric acid] and serotonin). 148 Postbiotic supplementation does not reveal side effects during human administration. 147 …”

Section: Postbiotics Are a Booster For Mental Healthmentioning

confidence: 99%

The influence of the gut-brain axis on anxiety and depression: A review of the literature on the use of probiotics

Ferrari,

Mulè,

Parini

et al. 2024

Journal of Traditional and Complementary Medicine

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Mood Disorders: The Gut Bacteriome and Beyond

Cited by 8 publications

References 139 publications

Sudden-Onset Acute Obsessive-Compulsive Disorder Associated with Streptococcus and Brain MRI Hyperintensity in a Young Adult

Sudden-Onset Acute Obsessive-Compulsive Disorder Associated with Streptococcus and Brain MRI Hyperintensity in a Young Adult

Žarnyno Ir Smegenų Ašies Reikšmė Psichiatrijai

The influence of the gut-brain axis on anxiety and depression: A review of the literature on the use of probiotics

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