Morbidity and Mortality From Malignant Neoplasms Associated With Human Papillomavirus

Objective: The epidemiological features of the cervical cancer (CC) incidence and its spatial and temporal assessment in Kazakhstan were studied. Methods: The retrospective study was done for the period 2009-2018. Descriptive and analytical methods of oncoepidemiology were used. Results: During the study period, 16,441 new cases of CC were registered. The average annual crude and age-standardized incidence rate were 18.6±0.5 and 17.7±0.4 cases per 100,000 population of female, respectively, and their trends tended to increase (Т up =+2.3%; R 2 =0.708 and Т up =+1.9%; R 2 =0.615, respectively). The analysis of ASIR showed unimodal growth with a peak at 50-54 years -45.3±1.1 cases per 100,000 population of female. Trends of ASIR decreased up to 30 years (T down =−1.8%; R 2 =0.111) and 35-59 years (T down =−0.9%; R 2 =0.103), in other age groups the trends increased, and were most pronounced in 40-44 (Т up =+4.1%; R 2 =0.878) and 65-69 years (Т up =+4.4%; R 2 =0.537). Trends in ASR of СС tended to grow in almost all regions, with higher levels in Mangystau (Т up =+4.1%; R 2 =0.482) and Aktobe (Т up =+6.3%; R 2 =0.846) regions. The cartograms of ASR per 100,000 population of female were allocated according to the following criteria: low -up to 16.3, averagefrom 16.3 to 19.2, high -above 19.2. The results of the spatial analysis showed the regions with a higher levels of CC incidence rate per 100,000 population of female: East Kazakhstan (19.8), Aktobe (20.0), Almaty (20.1), Kostanay region (20.9), Atyrau (21.7) regions and Almaty city (22.0). Conclusion: The study of trends of the cervical cancer incidence has the theoretical and practical value: monitoring and evaluation of screening programmes, which are implemented in the country, and conduction of secondary prevention of cervical pathology. Health authorities should consider the obtained results in the in the organization of anti-cancer activities.

show abstract

“…Zambia (65.5), Malawi (67.9) and Eswatini (84.5) (Ferlay et al, 2020;Curado et al, 2007;Gretsova et al, 2017;Zhang et al, 2020).…”

Section: New Trends Of Cervical Cancer Incidence In Kazakhstanmentioning

confidence: 99%

New Trends of Cervical Cancer Incidence in Kazakhstan

Igissinov

Igissinova

Telmanova

et al. 2021

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

“…However, if we consider the structure of oncological diseases of the female reproductive system, cervical cancer takes the second place in prevalence among malignant neoplasms of women under 45 years and the first in the number of lost years of life (the life expectancy of sick women is reduced by 26 years on average). The incidence of cervical cancer is steadily increasing and has increased by 28% on average over the past 10 years [7].…”

Section: Epidemiology Of Hpv-associated Pathology In Russia and Khmaomentioning

confidence: 99%

“…Only in 10 years, the incidence of cervical cancer in Russia has increased by an order of magnitude: from 7.9 per 100,000 of the female population in 2002 to 17.2in 2012 [7]. In 2018, 17,000 new cases of cervical cancer and 6.6 thousand deaths were registered in the Russian Federation.…”

Section: Epidemiology Of Hpv-associated Pathology In Russia and Khmaomentioning

confidence: 99%

The Importance of the Problem of HPV-Associated Diseases in KhMAO-Ugra: Vaccination of Adolescents against HPV - Problems and Prospects

Белоцерковцева¹,

Mayer²

2020

Human Papillomavirus

View full text Add to dashboard Cite

In a survey of adolescents aged 14-17 years, we found that 25% already have experience of sexual contact and they do not know the methods of contraception and neglect condoms. About 77.6% of sexually active adolescent girls had genital infection, including HPV 52.7%, highly oncogenic types 37.9%, and mixed infections 51.4%. Adolescents are extremely vulnerable to HPV-related diseases. Cervical cancer takes the 2nd place in the structure of cancer in women in KHMAO-Ugra and the 1st place at the age of 30 years. Since 2009, girls have been vaccinated against HPV in Ugra. Over 10 years, there was a 39% decrease in the incidence of anogenital warts. We meet with parents, provide information about the risks of HPV infection, expose myths, and discuss the safety and effectiveness of HPV vaccines. Our goal is to win the trust of parents in vaccines, resist anti-vaccine propaganda, increase motivation, and reduce the number of refusal.

show abstract

“…Так, в 2011 году частота рака влагалища на 100 тыс. населения составила 0,54, а в 2015 году -0,62 [2,3]. Преинвазивные признаки заболевания диагностируют в виде интраэпителиальных опухолевых изменений, называемых VAIN [1].…”

unclassified

Vaginal Intraepithelial Neoplasia: Diagnostics, Treatment, and Prevention

Zarochentseva¹,

Krasnopolsky²,

Dzhidzhikhiya³

et al. 2020

View full text Add to dashboard Cite

Цель обзора: обобщение научных данных о диагностике, лечении, профилактике влагалищных интраэпителиальных неоплазий (vaginal intraepithelial neoplasia, VAIN). Основные положения. VAIN-редкое бессимптомное предраковое заболевание. Основные факторы риска возникновения VAINинфицирование вирусом папилломы человека (ВПЧ) и ранее проведенная гистерэктомия. При диагностике применяются цитологическое исследование, ВПЧ-тестирование, вагиноскопия и биопсия. В качестве методов лечения VAIN используются CO 2-лазер, петлевая электроэксцизия, кавитационная ультразвуковая хирургическая аспирация, лучевая терапия и др. Заключение. Нельзя недооценивать опасность поражения влагалища у ВПЧ-позитивных пациенток даже после проведенной гистерэктомии. Влагалище следует исследовать во время каждой кольпоскопии. Вакцинация против ВПЧ является действенной мерой профилактики ВПЧ-ассоциированных раков и предраков, включая VAIN. Ключевые слова: интраэпителиальная неоплазия влагалища, рак влагалища, клинические проявления, фотодинамическая терапия, вакцинация, вирус папилломы человека.

show abstract

Morbidity and Mortality From Malignant Neoplasms Associated With Human Papillomavirus

Cited by 7 publications

References 4 publications

New Trends of Cervical Cancer Incidence in Kazakhstan

New Trends of Cervical Cancer Incidence in Kazakhstan

The Importance of the Problem of HPV-Associated Diseases in KhMAO-Ugra: Vaccination of Adolescents against HPV - Problems and Prospects

Vaginal Intraepithelial Neoplasia: Diagnostics, Treatment, and Prevention

Contact Info

Product

Resources

About