More insights about the interfering effect of Mycobacterium avium subsp. paratuberculosis (MAP) infection on Mycobacterium bovis (M. bovis) detection in dairy cattle

Raffo, Eduardo; Steuer, Pamela; Tomckowiack, Camilo; Tejeda, Carlos; Collado, Bernardita; Salgado, Miguel

doi:10.1007/s11250-019-02151-2

Cited by 11 publications

(8 citation statements)

References 35 publications

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“…Despite previous reports, we detected no evidence of infection by MAP in huemul and pudu. Gonza ´lez-Acu ña et al ( 2011) found lesions characteristic of paratuberculosis at necropsy of one pudu from Concepci ón, Bío-Bío Region, in 2005; however, no ancillary tests were performed to confirm MAP as the The lack of evidence of exposure or infection by M. bovis in pudu and huemul may be attributed to the low infection prevalence of M. bovis (0.3%) in livestock, the main reservoir in the sampled areas (Raffo et al 2019). Studies are needed for the detection of M. bovis in pudu and huemul populations inhabiting regions of high prevalence in livestock, such as Maule, Ñuble, and Bio-Bio, as well as in other wild species prone to be reservoirs, such as the wild boar (Sus scrofa).…”

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confidence: 99%

Lack of Exposure to Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis in Chilean Cervids, and Evidence of a New Mycobacterium-Like Sequence

Hidalgo-Hermoso

Ruiz‐Fons

Cabello-Stom³

et al. 2022

Journal of Wildlife Diseases

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Lack of Exposure to Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis in Chilean Cervids, and Evidence of a New Mycobacterium-Like Sequence

Hidalgo-Hermoso

Ruiz‐Fons

Cabello-Stom³

et al. 2022

Journal of Wildlife Diseases

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“…As tuberculosis has previously been confirmed in Polish zoos [ 36 , 37 ], it should be noted that MAP-positive animals can complicate the diagnosis of tuberculosis, due to cross-reactions [ 38 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium avium Subspecies paratuberculosis in Asymptomatic Zoo Herbivores in Poland

Bruczyńska

Didkowska

Brzezińska³

et al. 2023

Animals

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Mycobacterial infections are significant issues in zoo animals, influencing animal welfare, conservation efforts, and the zoonotic potential of pathogens. Although tuberculosis is recognised to be highly dangerous, paratuberculosis can also lead to animal losses and is potentially dangerous for humans. The aim of the current study was to confirm whether Mycobacterium avium spp. paratuberculosis (MAP) infections are currently present in zoos in Poland. Faeces samples (n = 131) were collected from different animal species from eight zoos in Poland. The faeces were decontaminated and inoculated into Herrold’s Egg Yolk Media. The species was determined using commercial DNA testing. The IS900 was checked using RT-PCR. The culture was positive in seven samples: five with M. avium, one with Mycobacterium fortiatum, and one without any identified Mycobacterium species. RT-PCR confirmed MAP genetic material in nine animals. Our findings represent the first confirmation of MAP in bongo (Tragelaphus eurycerus), indicating that it is present in Polish zoological gardens. Fortunately, the disease can be monitored more easily due to recent legislation (the Animal Health Law).

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“…Interferences in the diagnosis of bTB have been reported in MAP‐infected cattle. Overall, a decrease in the SP of the interferon‐gamma test and serological analysis has been observed 16,19,34,35 . However, the inverse relationship (MTC interference with MAP diagnosis) remains largely unknown 16,30 .…”

Section: Discussionmentioning

confidence: 99%

“…Overall, a decrease in the SP of the interferon-gamma test and serological analysis has been observed. 16,19,34,35 However, the inverse relationship (MTC interference with MAP diagnosis) remains largely unknown. 16,30 Other authors 19 observed a lower SE of bPTB-ELISA in co-infected animals.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the diagnostic accuracy of the serological test for paratuberculosis in cattle according to tuberculosis status

Jurado‐Martos,

Cardoso‐Toset,

Tarradas

et al. 2023

Veterinary Record

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BackgroundEnzyme‐linked immunosorbent assays (ELISAs) are the most widely used diagnostic tools in bovine paratuberculosis (bPTB) control. However, their diagnostic accuracy may be compromised by bovine tuberculosis (bTB) infection, as both diseases share diagnostic targets.MethodsThe bPTB and bTB infection status of 228 animals was determined using microbiological tissue culture as a reference test. The diagnostic performance (sensitivity, specificity, likelihood ratios and predictive values) of the bPTB‐ELISA on blood serum samples, taking into account the bPTB animal‐level prevalence of the area and the bTB status of the animals, was evaluated.ResultsA sensitivity of 40.7% (95% confidence interval [CI]: 27.5%–53.9%) and a specificity of 94.7% (95% CI: 91.4%–98.0%) were obtained for bPTB‐ELISA in all animals. A bPTB‐ELISA‐positive animal would have a post‐test probability of 70% or more of being infected in areas with a bPTB prevalence of 23% or more. A negative bPTB‐ELISA result, in areas with a bPTB prevalence of 41% or less, would rule out the disease with more than 70% certainty. In bTB‐positive animals, sensitivity increased (94.4% [95% CI: 81.4%–100%] vs. 25.1% [95% CI: 11.8%–38.4%]) and specificity decreased (82.6% [95% CI: 71.8%–93.4%] vs. 99.4% [95% CI: 98.0%–99.9%]). The bPTB‐ELISA is a good tool to rule out bPTB co‐infection in bTB‐positive animals, while in bTB‐negative animals, it allows confirmation of disease with more than 70% probability if disease prevalence is 6% or more.LimitationsThe observed differences could be enhanced by the effect of frequent application of the intradermal tuberculin test, which was unknown in the animals studied.ConclusionsThese results provide useful guidance for the application and interpretation of ELISA as a tool for bPTB disease control.

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More insights about the interfering effect of Mycobacterium avium subsp. paratuberculosis (MAP) infection on Mycobacterium bovis (M. bovis) detection in dairy cattle

Cited by 11 publications

References 35 publications

Lack of Exposure to Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis in Chilean Cervids, and Evidence of a New Mycobacterium-Like Sequence

Lack of Exposure to Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis in Chilean Cervids, and Evidence of a New Mycobacterium-Like Sequence

Mycobacterium avium Subspecies paratuberculosis in Asymptomatic Zoo Herbivores in Poland

Evaluation of the diagnostic accuracy of the serological test for paratuberculosis in cattle according to tuberculosis status

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