More Natural More Better: Triple Natural Anti-Oxidant Puerarin/Ferulic Acid/Polydopamine Incorporated Hydrogel for Wound Healing

Abstract

BackgroundDuring wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic acid (FA) are natural compounds derived from herbs that exhibit multiple pharmacological activities, such as antioxidant and anti-inflammatory effects. Polydopamine (PDA) is made from natural dopamine and shows excellent antioxidant function. Therefore, the combination of natural antioxidants into hydrogel dressing is a promising therapy for wound healing. Results Hybrid hydrogel wound dressings have been developed by incorporating PUE or FA via PDA nanoparticles (NPs) into polyethylene glycol diacrylate (PEG-DA) hydrogel. This hydrogel can load natural antioxidant drugs and retain the drug in the gel network for a long period due to the presence of PDA NPs. Under oxidative stress, this hydrogel can improve the activity of superoxide dismutase and glutathione peroxidase and reduce the levels of ROS and malondialdehyde, thus preventing oxidative damage to cells, and then promoting wound healing, tissue regeneration, and collagen accumulation. Conclusion Overall, this triple antioxidant hydrogel accelerates wound healing by alleviating oxidative injury. Our study thus provides a new way about co-delivery of multiple antioxidant natural molecules from herbs via antioxidant nanoparticles for wound healing and skin regeneration.

Effect of Combination of Some Phytoconstituents of Pharmacological Interest on Cutaneous Wound Healing in Diabetic Rats

“…This collaborative effort not only bolstered structural integrity but also expedited the healing process. The synergistic impact between these constituents in harnessing these mechanisms resulted in more robust wound tissues [20].…”

Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

“…Wound healing, as well as the process of scarring, is an essential course for repairing common damage caused by physical trauma, surgical incisions and other unexpected injuries. [1][2][3] To date, though an abundance of novel therapies and technologies such as the aesthetic stitching technique, and new dressing biomaterials 4,5 have been applied for the improvement of the process, the number of patients suffering from scarring problems is continuing to increase. It is estimated that there are more than 100 million new scar patients every year worldwide, and about 20% of them are affected by abnormal scars.…”