More states make gabapentin a Schedule V Controlled Substance

Collins, Sonya

doi:10.1016/j.ptdy.2021.09.016

Cited by 4 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, gabapentin is not a federally controlled substance, however, some states do monitor gabapentin in their PDMP as it has been present in cases involving polypharmacy related to drug toxicity 9 . For example, although Pennsylvania monitors prescriptions for gabapentin in their PDMP, New Jersey and Delaware do not 10 . Therefore, medical records were manually searched for preoperative and postoperative gabapentin prescriptions.…”

Section: Methodsmentioning

confidence: 99%

Preoperative Opioid Prescribers and Lumbar Fusion

Lambrechts¹,

Toci²,

Fried³

et al. 2023

Clinical Spine Surgery: A Spine Publication

View full text Add to dashboard Cite

Objective: To determine the impact of multiple preoperative opioid prescribers on postoperative patient opioid usage and patient-reported outcome measures after single-level lumbar fusion.Summary of Background Data: Prior literature has identified opioid prescriptions from multiple postoperative providers increase opioid usage rates. However, there is limited evidence on how multiple preoperative opioid prescribers affect postoperative opioid usage or clinical outcomes after a single-level lumbar fusion.Patients and Methods: A retrospective review of single-level transforaminal lumbar interbody fusion or posterolateral lumbar fusions between September 2017 and February 2020 at a single academic institution was performed. Patients were excluded if they were not identifiable in our state's prescription drugmonitoring program. Univariate comparisons and regression analyses identified factors associated with postoperative clinical outcomes and opioid usage.Results: Of 239 patients, 160 (66.9%) had one or fewer preoperative prescribers and 79 (33.1%) had > 1 prescribers. On regression analysis, the presence of multiple preoperative prescribers was an independent predictor of increased improvement in Visual Analog Scale (ΔVAS) Back (β = −1.61, P = 0.012) and the involvement of a nonoperative spine provider was an independent predictor of increased improvement in ΔVAS Leg (β = −1.53, P = 0.034). Multiple preoperative opioid prescribers correlated with an increase in opioid prescriptions postoperatively (β = 0.26, P = 0.014), but it did not significantly affect the amount of morphine milligram equivalents prescribed (β = −48.79, P = 0.146). A greater number of preoperative opioid prescriptions predicted worse improvements in VAS Back, VAS Leg, and Oswestry Disability Index and predicted increased postoperative opioid prescriptions, prescribers, and morphine milligram equivalents.Conclusions: Multiple preoperative opioid prescribers predicted increased improvement in postoperative back pain, whereas preoperative involvement of a nonoperative spine provider predicted improvements in leg pain after surgery. The number of preoperative opioid prescriptions was a better metric for predicting poor postoperative outcomes and increased opioid consumption compared with the number of preoperative opioid prescribers.

show abstract

Section: Methodsmentioning

confidence: 99%

Preoperative Opioid Prescribers and Lumbar Fusion

Lambrechts¹,

Toci²,

Fried³

et al. 2023

Clinical Spine Surgery: A Spine Publication

View full text Add to dashboard Cite

show abstract

“…Max's mother may be coping with unmet physical or mental health needs that could be addressed with proper referrals and direct treatment for his mother. 3…”

Section: Christine Mcgivney Do Audrey Christiansen MDmentioning

confidence: 99%

“…In light of growing evidence for abuse potential, over recent years, several states have flagged gabapentin as a Schedule V Controlled Substance (AL, KY, MI, ND, TN, VA, and WV), and an increasing number of states have added gabapentin to their drug monitoring programs (CT, DC, IN, KS, MA, MN, NE, NJ, OH, OR, UT, and WY). 3…”

Section: Christine Mcgivney Do Audrey Christiansen MDmentioning

confidence: 99%

Raising the Question: Medication Mix-Up or Diversion

Reilly

McGivney

Christiansen

et al. 2022

J Dev Behav Pediatr

View full text Add to dashboard Cite

CASE:Max is an 8-year-old boy with autism spectrum disorder and long-standing challenges with sleep maintenance, the latter of which persist despite behavioral intervention and environmental modification. When Max wakes in the early morning hours, he tends to wander the house, which causes his mother to be awake to monitor his safety. Given the impact of Max's fragmented sleep on his functioning and that of his family, you begin a trial of gabapentin liquid to promote sleep maintenance. Soon after, Max's mother reports that he is sleeping through the night, for the first time in his life.Two months later, you receive a message from Max's mother requesting an early refill of his 90-day supply because of having spilled the bottle. You provide a new prescription, and Max's insurance company allows the early refill. Six weeks after that, Max's mother calls to say that she needs another gabapentin prescription because Max has run out. You confirm that she is giving the prescribed dose but are unsure as to why Max is out of medication weeks early. Given these events, you begin to question whether Max's gabapentin prescription is being diverted. What would you do next?

show abstract

“…4 Gabapentin is unscheduled by the DEA, although five states have classified gabapentin as schedule V and 12 others require reporting of gabapentin prescriptions. 5 Prevalence of gabapentinoid use in the United States doubled from 2007 to 2015 (from <2% to 4% of the population), and the number of gabapentinoid prescriptions increased 146% during the same period. 2 In 2020 gabapentin was the seventh most-prescribed medication in the United States.…”

mentioning

confidence: 99%

“…Pregabalin is classified as a schedule V substance by the United States Drug Enforcement Administration (DEA) due to modest euphoric effects in one clinical trial . Gabapentin is unscheduled by the DEA, although five states have classified gabapentin as schedule V and 12 others require reporting of gabapentin prescriptions . Prevalence of gabapentinoid use in the United States doubled from 2007 to 2015 (from <2% to 4% of the population), and the number of gabapentinoid prescriptions increased 146% during the same period .…”

mentioning

confidence: 99%

Effects of Gabapentinoids on Heroin-Induced Ventilatory Depression and Reversal by Naloxone

Flynn

France

2023

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

Despite an increasing prevalence of gabapentinoids (gabapentin and pregabalin) in opioid overdose deaths, little research has evaluated potentially harmful interactions between gabapentinoids and opioids. This study sought to determine the effects of gabapentinoids on the ventilatory depressive effects of heroin and their reversal by naloxone. Rats were given gabapentin, pregabalin, or saline prior to receiving increasing doses of heroin while ventilation was monitored using whole-body plethysmography. In some sessions naloxone was administered following the largest dose of heroin. The primary outcomes of this study were minute volume and Pause. Heroin dose-dependently reduced minute volume and increased Pause. Administration of naloxone dose-dependently reversed the effects of heroin on ventilation. Gabapentinoids did not alter the ventilatory depressive effects of heroin alone but reduced the potency of naloxone to reverse heroin-induced ventilatory depression. These preliminary findings emphasize the need for further research evaluating interactions between gabapentinoids and opioids related to substance misuse and overdose.

show abstract

More states make gabapentin a Schedule V Controlled Substance

Abstract: states over the last 5 years. During that same time period, 12 other states have placed the drug in their prescription drug monitoring programs (PMP). Three others are in the process of adding the prescription medication to Schedule V lists or state PMPs.

Cited by 4 publications

References 0 publications

Preoperative Opioid Prescribers and Lumbar Fusion

Preoperative Opioid Prescribers and Lumbar Fusion

Raising the Question: Medication Mix-Up or Diversion

Effects of Gabapentinoids on Heroin-Induced Ventilatory Depression and Reversal by Naloxone

Contact Info

Product

Resources

About