More than L2b in rectal lymphogranuloma venereum

Fermepin, Marcelo Rodríguez; Entrocassi, Andrea Carolina; Büttner, Karina A; Caffarena, Dolores; Aquino, Deysi López; Rosa, Luciana La; López, Laura Svidler

doi:10.1016/s2666-5247(20)30225-1

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…In that context, the predominance of LGV biovar causing anorectal symptoms was an unexpected finding. But the most surprising fact was the detection of the L1 genotype, 10 which had not been reported worldwide in literature since the 1980s. 11 In the present series, although L2b was the most frequent genotype diagnosed in North American and European countries, 12,13 L1 was detected in almost one-third of LGV positive patients, being more frequent than L2.…”

Section: Discussionmentioning

confidence: 99%

Chlamydia trachomatis anorectal infections by LGV (L1, L2 and L2b) and non-LGV serotypes in symptomatic patients in Buenos Aires, Argentina

et al. 2021

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Background Chlamydia trachomatis (CT) can infect the anorectum producing various signs and symptoms. There is scarce literature regarding the differences between LGV and non-LGV CT anorectal manifestations. We compare the clinical spectrum of LGV and non-LGV infections. Methods Patients over 18 years with presumptive infectious anorectal symptoms were examined in two healthcare centres in Buenos Aires. The patients were studied and treated according to current sexually transmitted infection guidelines. Anorectal swabs were collected to detect and genotype CT. Results A three-year-long study on 317 patients with anorectal symptoms showed 45.11% CT infection (85% LGV strains). Of 140 samples, 92 were sequenced: 80/119 LGV (L2b 45%, L1 32.5% and L2 22.5%) and 12/21 non-LGV. Older age and HIV+ status were significantly higher in the LGV group. Anal discharge, bleeding, severe proctitis and anal ulcers were more common in the LGV group. Multivariate logistic regression analysis revealed that HIV infection, anorectal bleeding and oro-anal sex are independent predictors of LGV infection. Conclusions In patients with anorectal symptoms, LGV serovars predominate over non-LGV ones. Clinical manifestations are not pathognomonic of a specific biovar. If genotyping is not available, having clinical predictors may help to presume an LGV infection and define length of treatment.

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Section: Discussionmentioning

confidence: 99%

Chlamydia trachomatis anorectal infections by LGV (L1, L2 and L2b) and non-LGV serotypes in symptomatic patients in Buenos Aires, Argentina

et al. 2021

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“…The proportion of the ompA genotype L1 variant was unexpectedly large (8.9%) in 2022; this occurrence was not associated with clinical factors (HIV status or presence of anorectal symptoms) or the spatial distribution. A small L1 cluster was described in Seattle in the 1980s but did not spread further until its recent description in Argentina, where it accounted for 20.5% of symptomatic LGV cases [28,29]. No increase in the ompA genotype L1 variant has yet been reported in Europe [7,9,22,23,25].…”

Section: Discussionmentioning

confidence: 99%

Anorectal lymphogranuloma venereum among men who have sex with men: a 3-year nationwide survey, France, 2020 to 2022

Peuchant,

Laurier-Nadalié,

Albucher

et al. 2024

Eurosurveillance

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Background In France, lymphogranuloma venereum (LGV) testing switched from universal to selective testing in 2016. Aim To investigate changes in LGV-affected populations, we performed a nationwide survey based on temporarily reinstated universal LGV testing from 2020 to 2022. Methods Each year, during three consecutive months, laboratories voluntarily sent anorectal Chlamydia trachomatis-positive samples from men and women to the National Reference Centre for bacterial sexually transmitted infections. We collected patients’ demographic, clinical and biological data. Genovars L of C. trachomatis were detected using real-time PCR. In LGV-positive samples, the ompA gene was sequenced. Results In 2020, LGV positivity was 12.7% (146/1,147), 15.2% (138/907) in 2021 and 13.3% (151/1,137) in 2022 (p > 0.05). It occurred predominantly in men who have sex with men (MSM), with rare cases among transgender women. The proportion of HIV-negative individuals was higher than that of those living with HIV. Asymptomatic rectal LGV increased from 36.1% (44/122) in 2020 to 52.4% (66/126) in 2022 (p = 0.03). Among users of pre-exposure prophylaxis (PrEP), LGV positivity was 13.8% (49/354) in 2020, 15.6% (38/244) in 2021 and 10.9% (36/331) in 2022, and up to 50% reported no anorectal symptoms. Diversity of the LGV ompA genotypes in the Paris region increased during the survey period. An unexpectedly high number of ompA genotype L1 variant was reported in 2022. Conclusion In rectal samples from MSM in France, LGV positivity was stable, but the proportion of asymptomatic cases increased in 2022. This underscores the need of universal LGV testing and the importance of continuous surveillance.

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Chlamydia trachomatisgenomes from rectal samples: description of new clade comprisingompA-genotype L4 from Argentina

Büttner,

Wegner,

Bregy

et al. 2024

Preprint

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Whole genome analysis has provided us with insights into the evolution of Chlamydia trachomatis and recently into circulating strains which cause lymphogranuloma venereum (LGV). A large LGV outbreak of a new ompA-genotype, L2b, was first reported in Europe in the early 2000s, primarily affecting men who have sex with men (MSM), and then expanded globally. More recent work shows this outbreak diversifying into variants of described ompA-genotypes, with the same L2b genomic backbone. This study extends the investigation of LGV cases to Argentina and Finland. In 2017, an LGV outbreak was described in Argentina characterized by distinct genomic features shown by both ompA-genotyping and MLST analysis. We have obtained whole genome sequences from cultured isolates and clinical samples via SureSelect (Agilent) target enrichment. Based on ompA and phylogenetic analyses, we describe further diversity within the ompA-genotype L2b clade, illustrating the transmission dynamics in both Argentina and Finland. A key finding is that of a novel clade of Argentinian samples, characterised by a proposed new ompA-genotype L4. Additionally, we present the genome sequence of a non-LGV strain associated with anorectal proctitis. These findings contribute to the investigation of LGV evolution, particularly with the presence of the novel L4 lineage, and provide insights into genomic diversity and transmission dynamics of C. trachomatis.

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More than L2b in rectal lymphogranuloma venereum

Cited by 4 publications

References 6 publications

Chlamydia trachomatis anorectal infections by LGV (L1, L2 and L2b) and non-LGV serotypes in symptomatic patients in Buenos Aires, Argentina

Chlamydia trachomatis anorectal infections by LGV (L1, L2 and L2b) and non-LGV serotypes in symptomatic patients in Buenos Aires, Argentina

Anorectal lymphogranuloma venereum among men who have sex with men: a 3-year nationwide survey, France, 2020 to 2022

Chlamydia trachomatisgenomes from rectal samples: description of new clade comprisingompA-genotype L4 from Argentina

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