More than movement: the proprioceptive system as a new regulator of musculoskeletal biology

Bornstein, Bavat; Konstantin, Nitzan; Alessandro, Cristiano; Tresch, Matthew C.; Zelzer, Elazar

doi:10.1016/j.cophys.2021.01.004

Cited by 13 publications

(21 citation statements)

References 144 publications

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“…1) (Johnson et al 2008;Proske and Gandevia 2012). Recently, the proprioceptive system has also been recognised as playing a role beyond postural and movement control (Bornstein et al 2021). In particular, the proprioceptive system has been implicated in musculoskeletal biology and development, such as regulating spinal alignment and joint development (Bornstein et al 2021).…”

Section: Altered Deep Muscle Mechanoreceptive Afferents Due To Vertebral Dysfunction Spinal Adjustments or Manipulationmentioning

confidence: 99%

“…Recently, the proprioceptive system has also been recognised as playing a role beyond postural and movement control (Bornstein et al 2021). In particular, the proprioceptive system has been implicated in musculoskeletal biology and development, such as regulating spinal alignment and joint development (Bornstein et al 2021). Of particular importance is the presence and number of the major mechanotransducers of mammalian proprioceptors, the ion channel called Piezo2 (Bornstein et al 2021), which are known to be expressed in dorsal root ganglia neurons with muscle spindle and GTO endings (Woo et al 2015).…”

Section: Altered Deep Muscle Mechanoreceptive Afferents Due To Vertebral Dysfunction Spinal Adjustments or Manipulationmentioning

confidence: 99%

“…In particular, the proprioceptive system has been implicated in musculoskeletal biology and development, such as regulating spinal alignment and joint development (Bornstein et al 2021). Of particular importance is the presence and number of the major mechanotransducers of mammalian proprioceptors, the ion channel called Piezo2 (Bornstein et al 2021), which are known to be expressed in dorsal root ganglia neurons with muscle spindle and GTO endings (Woo et al 2015). Muscle spindles (tiny stretch receptors within muscles), mechanoreceptors in joint capsules and cutaneous tactile receptors are sources of afferent information required for accurate joint position sense (Blum et al 2017;Brumagne et al 2000;Burgess et al 1982;Cordo et al 2002;Gilman 2002).…”

Section: Altered Deep Muscle Mechanoreceptive Afferents Due To Vertebral Dysfunction Spinal Adjustments or Manipulationmentioning

confidence: 99%

Section: Altered Deep Muscle Mechanoreceptive Afferents Due To Vertebral Dysfunction Spinal Adjustments or Manipulationmentioning

confidence: 99%

“…On a final note, it is essential also to recognise that recent research suggests that the proprioceptive system seems to be important for far more than just the control and coordination of movement and posture (Bornstein et al 2021). Bornstein et al (2021) have recently highlighted that the proprioceptive system is also implicated in regulating a wide range of developmental and physiological processes (Bornstein et al 2021). For example, they discuss the role and function of the Piezo2 ion channel that is the major mechanotransducer of mammalian proprioceptors, including proprioceptors found in neurons ending in muscle spindles and GTOs (Bornstein et al 2021).…”

Section: Altered Deep Muscle Mechanoreceptive Afferents Due To Vertebral Dysfunction Spinal Adjustments or Manipulationmentioning

confidence: 99%

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The contemporary model of vertebral column joint dysfunction and impact of high-velocity, low-amplitude controlled vertebral thrusts on neuromuscular function

et al. 2021

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Purpose There is growing evidence that vertebral column function and dysfunction play a vital role in neuromuscular control. This invited review summarises the evidence about how vertebral column dysfunction, known as a central segmental motor control (CSMC) problem, alters neuromuscular function and how spinal adjustments (high-velocity, low-amplitude or HVLA thrusts directed at a CSMC problem) and spinal manipulation (HVLA thrusts directed at segments of the vertebral column that may not have clinical indicators of a CSMC problem) alters neuromuscular function. Methods The current review elucidates the peripheral mechanisms by which CSMC problems, the spinal adjustment or spinal manipulation alter the afferent input from the paravertebral tissues. It summarises the contemporary model that provides a biologically plausible explanation for CSMC problems, the manipulable spinal lesion. This review also summarises the contemporary, biologically plausible understanding about how spinal adjustments enable more efficient production of muscular force. The evidence showing how spinal dysfunction, spinal manipulation and spinal adjustments alter central multimodal integration and motor control centres will be covered in a second invited review. Results Many studies have shown spinal adjustments increase voluntary force and prevent fatigue, which mainly occurs due to altered supraspinal excitability and multimodal integration. The literature suggests physical injury, pain, inflammation, and acute or chronic physiological or psychological stress can alter the vertebral column’s central neural motor control, leading to a CSMC problem. The many gaps in the literature have been identified, along with suggestions for future studies. Conclusion Spinal adjustments of CSMC problems impact motor control in a variety of ways. These include increasing muscle force and preventing fatigue. These changes in neuromuscular function most likely occur due to changes in supraspinal excitability. The current contemporary model of the CSMC problem, and our understanding of the mechanisms of spinal adjustments, provide a biologically plausible explanation for how the vertebral column’s central neural motor control can dysfunction, can lead to a self-perpetuating central segmental motor control problem, and how HVLA spinal adjustments can improve neuromuscular function.

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Section: Altered Deep Muscle Mechanoreceptive Afferents Due To Vertebral Dysfunction Spinal Adjustments or Manipulationmentioning

confidence: 99%

Section: Altered Deep Muscle Mechanoreceptive Afferents Due To Vertebral Dysfunction Spinal Adjustments or Manipulationmentioning

confidence: 99%

Section: Altered Deep Muscle Mechanoreceptive Afferents Due To Vertebral Dysfunction Spinal Adjustments or Manipulationmentioning

confidence: 99%

Section: Altered Deep Muscle Mechanoreceptive Afferents Due To Vertebral Dysfunction Spinal Adjustments or Manipulationmentioning

confidence: 99%

Section: Altered Deep Muscle Mechanoreceptive Afferents Due To Vertebral Dysfunction Spinal Adjustments or Manipulationmentioning

confidence: 99%

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The contemporary model of vertebral column joint dysfunction and impact of high-velocity, low-amplitude controlled vertebral thrusts on neuromuscular function

et al. 2021

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Reciprocal interactions between transforming growth factor beta signaling and collagens: Insights from Caenorhabditis elegans

Goodman

Savage-Dunn

2021

Developmental Dynamics

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Studies in genetically tractable organisms such as the nematode Caenorhabditis elegans have led to pioneering insights into conserved developmental regulatory mechanisms. For example, Smad signal transducers for the transforming growth factor beta (TGF‐β) superfamily were first identified in C. elegans and in the fruit fly Drosophila. Recent studies of TGF‐β signaling and the extracellular matrix (ECM) in C. elegans have forged unexpected links between signaling and the ECM, yielding novel insights into the reciprocal interactions that occur across tissues and spatial scales, and potentially providing new opportunities for the study of biomechanical regulation of gene expression.

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Kinesthetic Coordination Abilities in 6-Year-Old Children: School Quintile, Gender, and Hand Dominance Differences

Bonafede

Waal

2023

IJEC

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Proprioceptive kinaesthetic control underpins motor movements of developing children and can be influenced by several factors. The main aim of this study was to establish proprioceptive kinaesthetic coordination differences in six-year-olds from different school quintiles, of different genders, and with different handedness. A total of 193 six-year-olds from 10 schools of different quintiles in the Motheo District, Mangaung, were included, of which 97 (50.3%) were boys and 96 (49.7%) were girls. A quantitative cross-sectional study design was followed to determine proprioceptive kinaesthetic coordination differences. Right-handed participants performed significantly better than left-handed participants in the Finger-to-Nose task (p = 0.0125) when moving and positioning their dominant arm and hand. When using their dominant arm, significant differences in the shoulder-level-arm-raise (p = 0.0288) favoured boys. Girls showed superior execution of the force perception task (p = 0.0322). In conclusion, significant proprioceptive kinaesthetic coordination differences in six-year-olds were mainly not evident. Future work should explore proprioceptive kinaesthetic coordination differences in children of other ages and determine the practical implications of identified differences.

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More than movement: the proprioceptive system as a new regulator of musculoskeletal biology

Cited by 13 publications

References 144 publications

The contemporary model of vertebral column joint dysfunction and impact of high-velocity, low-amplitude controlled vertebral thrusts on neuromuscular function

The contemporary model of vertebral column joint dysfunction and impact of high-velocity, low-amplitude controlled vertebral thrusts on neuromuscular function

Reciprocal interactions between transforming growth factor beta signaling and collagens: Insights from Caenorhabditis elegans

Kinesthetic Coordination Abilities in 6-Year-Old Children: School Quintile, Gender, and Hand Dominance Differences

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