More vulnerability of left than right hippocampal damage in right-handed patients with post-traumatic stress disorder

Shu, Xin; Xue, Li; Liu, Wei; Chen, Fu-Yin; Zhu, Cheng; Sun, Xiufa; Wang, Xiaoping; Liu, Zhong-Cun; Zhao, Hu

doi:10.1016/j.pscychresns.2012.04.009

Cited by 34 publications

(38 citation statements)

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“…Because of its involvement in the limbichypothalamic-pituitary-adrenal axis, the hippocampus is vulnerable to neuronal degeneration after severe biological/psychological stress (13,14). Post-traumatic stress disorder associates with reduced hippocampal volumes (15,16), and hippocampal degeneration also occurs in rats after anoxia and mild hypothermia (17). Preoperative leukoaraiosis and lacunae volume, by contrast, may indicate vulnerability to postoperative executive decline.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study Evaluating Presurgery Neuroanatomical Biomarkers for Postoperative Cognitive Decline After Total Knee Arthroplasty in Older Adults

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Schmalfuss

et al. 2014

Survey of Anesthesiology

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Background-Total knee arthroplasty improves quality of life but is associated with postoperative cognitive dysfunction in older adults. This prospective longitudinal pilot study with a parallel control group tested the hypotheses that: 1) nondemented adults would exhibit primary memory and executive difficulties after total knee arthroplasty, and 2) reduced preoperative hippocampus/entorhinal volume would predict postoperative memory change, whereas preoperative leukoaraiosis and lacunae volumes would predict postoperative executive dysfunction.

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Section: Introductionmentioning

confidence: 99%

A Pilot Study Evaluating Presurgery Neuroanatomical Biomarkers for Postoperative Cognitive Decline After Total Knee Arthroplasty in Older Adults

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Schmalfuss

et al. 2014

Survey of Anesthesiology

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“…[22,26,41]. The hippocampal atrophy is correlated with Alzheimer's disease and mild cognitive impairment for the right hippocampus [49].…”

Section: Discussionmentioning

confidence: 98%

“…Some authors found in schizophrenic patients certain neurochemical lateralisation in the HF in relation to quantity of the glutamate receptors and size of the pyramidal cell synapses [13,40]. Finally, functional or pathophysiological right-left HF asymmetry was noticed in memory processing [9], language acquisition [23], posttraumatic stress disorders [41,48], and cognitive decline of various causes [10].…”

Section: Discussionmentioning

confidence: 99%

“…Malformation, disorder or damage of the HF have a great importance in the pathogenesis, or consequences, of the variety of the neurological and psychiatric disorders, e.g. the epilepsy, schizophrenia, amnesia, depression, anxiety, posttraumatic stress, aging, Alzheimer's and Parkinson's disease [14,26,37,38,41,42,49]. Even the slightest volume changes, which can be identified by modern imaging techniques, may indicate certain neuropathology or pathophysiology in this region.…”

Section: Introductionmentioning

confidence: 99%

“…on the lateralisation of certain functions in the cerebral hemispheres [30,41,44], as well as on the age of the examined patients [2,8,16,30,33]. Some studies indicated that certain cognitive functions or the particular neurological diseases affecting the HF have preference for the left or the right hippocampus of either the left-or right-handed persons, in whom they usually cause a reduction of the grey matter [10,20,28,29].…”

Section: Introductionmentioning

confidence: 99%

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A 3 tesla magnetic resonance imaging volumetric analysis of the hippocampal formation: dependence on handedness and age

Lazić¹,

Stošić-Opinćal²,

Petronijević³

et al. 2015

Folia Morphol

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Early putamen hypertrophy and ongoing hippocampus atrophy predict cognitive performance in the first ten years of relapsing-remitting multiple sclerosis

et al. 2020

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Background The first years of relapsing-remitting multiple sclerosis (RRMS) constitute the most vulnerable phase for the progression of cognitive impairment (CImp), due to a gradual decrease of compensatory mechanisms. In the first 10 years of RRMS, the temporal volumetric changes of deep gray matter structures must be clarified, since they could constitute reliable cognitive biomarkers for diagnostic, prognostic, and therapeutic purposes. Methods Forty-five cognitively asymptomatic patients with RRMS lasting ≤ 10 years, and with a brain MRI performed in a year from the neuropsychological evaluation (Te-MRI), were included. They performed the Brief International Cognitive Assessment battery for MS. Thirty-one brain MRIs performed in the year of diagnosis (Td-MRI) and 13 brain MRIs of age-and sex-matched healthy controls (HCs) were also included in the study. The relationships between clinical features, cognitive performances, and Te-and Td-MRI volumes were statistically analyzed. Results Cognitively preserved (CP) patients had significantly increased Td-L-putamen (P = 0.035) and Td-R-putamen volume (P = 0.027) with respect to cognitively impaired (CI) ones. CI patients had significantly reduced Te-L-hippocampus (P = 0.019) and Te-R-hippocampus volume (P = 0.042) compared, respectively, with Td-L-hippocampus and Td-R-hippocampus volume. Td-L-putamen volume (P = 0.011) and Te-L-hippocampus volume (P = 0.023) were independent predictors of the Symbol Digit Modalities Test score in all patients (r2 = 0.31, F = 6.175, P = 0.001). Conclusion In the first years of RRMS, putamen hypertrophy and hippocampus atrophy could represent promising indices of cognitive performance and reserve, and become potentially useful tools for diagnostic, prognostic, and therapeutic purposes.

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More vulnerability of left than right hippocampal damage in right-handed patients with post-traumatic stress disorder

Cited by 34 publications

References 50 publications

A Pilot Study Evaluating Presurgery Neuroanatomical Biomarkers for Postoperative Cognitive Decline After Total Knee Arthroplasty in Older Adults

A Pilot Study Evaluating Presurgery Neuroanatomical Biomarkers for Postoperative Cognitive Decline After Total Knee Arthroplasty in Older Adults

A 3 tesla magnetic resonance imaging volumetric analysis of the hippocampal formation: dependence on handedness and age

Early putamen hypertrophy and ongoing hippocampus atrophy predict cognitive performance in the first ten years of relapsing-remitting multiple sclerosis

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