Morin hydrate

Kok, L.D.S.; Wong, Yum-Shing; Wu, Tai-Wing; Chan, H. P.; Kwok, Tsz-Ho; Fung, Kwok‐Pui

doi:10.1016/s0024-3205(00)00605-6

Cited by 86 publications

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“…1, is a light yellowish natural plant dye and is known to have a broad spectrum of biological activities: antioxidant [1,2], anti-inflammatory [3], anticancer [4][5][6], cardiovascular protection [7,8], etc. The bioactivity of morin is connected with its structural features which can be involved in complex formation with metals [9].…”

Section: Introductionmentioning

confidence: 99%

New complexes of La(III), Ce(III), Pr(III), Nd(III), Sm(III), Eu(III) and Gd(III) ions with morin

Woźnicka

Kopacz

Umbreit

et al. 2007

Journal of Inorganic Biochemistry

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Section: Introductionmentioning

confidence: 99%

New complexes of La(III), Ce(III), Pr(III), Nd(III), Sm(III), Eu(III) and Gd(III) ions with morin

Woźnicka

Kopacz

Umbreit

et al. 2007

Journal of Inorganic Biochemistry

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“…It is one of the antioxidants that can protect various human cells, such as myocytes, endothelial cells, and hepatocytes against oxyradicals generated in situ. Studies undertaken imply that morin may protect the cardiovascular tissues of cancer patients from free-radical-mediated damage when doxorubicin or mitomycin C are used in chemotherapy [20]. The antioxidant activity of quercetin is almost twice morins antioxidant activity which indicates the importance of the adjacent two hydroxyl groups in the ortho-diphenolic arrangement in the ring-B of hydroxyflavones [5,21].…”

Section: Introductionmentioning

confidence: 99%

Solid State Electrochemical Oxidation Mechanisms Of Morin in Aqueous Media

Janeiro

Oliveira-Brett

2005

Electroanalysis

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The mechanism of electrochemical oxidation of morin has been studied using cyclic, differential pulse and squarewave voltammetry techniques in aqueous electrolyte with solid, insoluble morin hydrate mechanically transferred to a glassy carbon electrode surface, over a wide pH range. The oxidation mechanism proceeds in sequential steps, related with the hydroxyl groups in the three aromatic rings and the oxidation is pH dependent over part of the pH range the oxidation potentials are shifted to lower values with increasing pH. Oxidation of the 2',4'dihydroxy moiety at the B ring of morin occurs first, at very low positive potentials, and is a one electron one proton reversible reaction. The hydroxyl groups oxidized at more positive potentials were shown to undergo an irreversible oxidation reaction.

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“…Morin is a potent antioxidant, which was found to exert strong inhibitory effect on ROS generation [8]. It is also an effective free radical scavenger [50]. Morin was reported to restore the expression, activities of antioxidant enzymes and levels of GSH [8].…”

Section: Discussionmentioning

confidence: 99%

Alleviating effects of morin against experimentally-induced diabetic osteopenia

Abuohashish

Al‐Rejaie

Alhosaini

et al. 2013

Diabetol Metab Syndr

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BackgroundPlant flavonoids are emerging as potent therapeutic drugs effective against a wide range of aging diseases particularly bone metabolic disorders. Morin (3,5,7,20,40-pentahydroxyflavone), a member of flavonols, is an important bioactive compound by interacting with nucleic acids, enzymes and protein. The present study was designed to investigate the putative beneficial effect of morin on diabetic osteopenia in rats.MethodsStreptozotocin (STZ)-induced diabetic model was used by considering 300 mg/dl fasting glucose level as diabetic. Morin (15 and 30 mg/kg) was treated for five consecutive weeks to diabetic rats. Serum levels of glucose, insulin, deoxypyridinoline cross links (DPD), osteocalcin (OC), bone specific alkaline phosphatase (BALP), telopeptides of collagen type I (CTX), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), thiobarbituric acid reactive substance (TBARS) and reduced glutathione (GSH) were estimated. Femoral bones were taken for micro CT scan to measure trabecular bone mineral density (BMD) and other morphometric parameters.ResultsSignificant bone loss was documented as the level of bone turnover parameters including DPD, OC, BALP and CTX were increased in serum of diabetic rats. Morin treatment significantly attenuated these elevated levels. Bone micro-CT scan of diabetic rats showed a significant impairment in trabecular bone microarchitecture, density and other morphometric parameters. These impairments were significantly ameliorated by morin administration. Serum levels of glucose, TBARS, IL-1β, IL-6 and TNF-α were significantly elevated, while the level of insulin and GSH was decreased in diabetic rats. These serum changes in diabetic rats were bring back to normal values after 5 weeks morin treatment.ConclusionThese findings revealed the protective effect of morin against diabetic induced osteopenia. We believed that this effect is through its both the anti-inflammatory and antioxidant properties.

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Morin hydrate

Cited by 86 publications

References 0 publications

New complexes of La(III), Ce(III), Pr(III), Nd(III), Sm(III), Eu(III) and Gd(III) ions with morin

New complexes of La(III), Ce(III), Pr(III), Nd(III), Sm(III), Eu(III) and Gd(III) ions with morin

Solid State Electrochemical Oxidation Mechanisms Of Morin in Aqueous Media

Alleviating effects of morin against experimentally-induced diabetic osteopenia

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