Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats

Balakrishnan, Brindha Banu; Krishnasamy, Kalaivani; Vijayakumar, M.; Arokiyaraj, Selvaraj

doi:10.1016/j.biopha.2019.108688

Cited by 32 publications

(17 citation statements)

References 37 publications

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“…ALT, AST, and ALP are important biomarkers for the determination of hepatocellular damage. Hepatic injury causes these liver function enzymes to leak into the blood resulting in elevated levels of these enzymes (Balakrishnan, Krishnasamy, Mayakrishnan, & Selvaraj, 2019; Goboza, Aboua, Chegou, & Oguntibeju, 2019). Diabetic animals showed elevated ALT, AST, and ALP, however, treatment with T. triandra (especially 400 mg/kg of the extract) notably decreased the level of these enzymes.…”

Section: Discussionmentioning

confidence: 99%

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

2020

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The antidiabetic properties of Tiliacora triandra ethanol extract in diabetic rats induced with high‐fat diet (HFD)/streptozotocin (STZ) was investigated. Rats were fed with HFD for 4 weeks to induced insulin resistance, and thereafter administered with 35 mg/kg of STZ to induce diabetes. Diabetic rats received 100 and 400 mg/kg of T. triandra daily for 30 days. The body weight, blood glucose level, food and fluid intake were monitored. Furthermore, biochemical and histological assessment was performed to evaluate the hypoglycemic effect of the extract in the treated rats. T. triandra significantly decreased the blood glucose level, increased the body weight and insulin secretion. Furthermore, T. triandra attenuated hyperlipidemia, improved liver and kidney functions of treated diabetic rats. Thus, T. triandra could effectively attenuate diabetes and it complications. Practical applications Tiliacora triandra is a common vegetable consumed in Thailand and Laos. It is traditionally employed in the treatment of fever, cancer, malaria, and diabetes. The extract from the aerial part was investigated for its antidiabetic properties. The results obtained provides important pharmacological information that supports the use of T. triandra in management of diabetes.

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Section: Discussionmentioning

confidence: 99%

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

2020

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“…e resulting liver injury can progress to liver fibrosis and sclerosis [20]. Serum enzymes, such as ALT, AST, and LDH, are useful markers for detecting liver damage because activities of these enzymes are markedly elevated when hepatocytes are damaged [21].…”

Section: Discussionmentioning

confidence: 99%

CCl₄-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway

Peng

Zhou

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Qi-Ge decoction (QGD), which is derived from the Huangqi Gegen decoction, contains three traditional Chinese herbs: Astragalus membranaceus (Huangqi), Pueraria lobata (Gegen), and Citri Reticulatae Blanco Pericarpium (Chenpi). Gastric mucosal damage caused by ethanol was prevented and alleviated by QGD. However, the role of QGD in protecting the liver from toxins has not been reported. High-performance liquid chromatography with diode-array detection was used to qualitatively analyze QGD. Positive control (silymarin 100 mg/kg/day), QGD (20, 10, or 5 g/kg/day), and Nrf2 inhibitor brusatol (0.4 mg/kg/2 d) were administered to rats for 7 days, and then, liver injury was induced by injecting 2 mL/kg 25% CCl4. After 24 h, blood and liver were collected for analysis and evaluation. QGD was found to contain 12 main components including calycosin, puerarin, and hesperidin. QGD treatment significantly reduced liver damage and decreased serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase activities. QGD increased superoxide dismutase and catalase activities, and glutathione levels, but decreased malondialdehyde levels in livers from CCl4-treated rats. Compared to rats treated with CCl4 alone, after QGD administration, mRNA and protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 were increased, while those of Kelch-like ECH-related protein 1 (Keap1) and cytochrome P450 (CYP)2E1 were decreased. However, these improvements in QGD were reversed by brusatol. In conclusion, QGD can achieve its hepatoprotective effect through an antioxidant mechanism by activating the Nrf2 pathway.

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“…More than one decade ago, PPARγ was reported to be closely re- 169,170,172,[193][194][195][196] Kaempferia parviflora, Moringa concanensis Nimmo, Resveratrol 2019 42,95,197,198 signalling. The animal experiments showed that hispidulin administration could suppress tumour growth and lung metastasis.…”

Section: Pparγ Natural Agonists In Liver Cancermentioning

confidence: 99%

Therapeutic potential of PPARγ natural agonists in liver diseases

Guo

2020

J Cellular Molecular Medi

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Peroxisome proliferator‐activated receptor gamma (PPARγ) is a vital subtype of the PPAR family. The biological functions are complex and diverse. PPARγ plays a significant role in protecting the liver from inflammation, oxidation, fibrosis, fatty liver and tumours. Natural products are a promising pool for drug discovery, and enormous research effort has been invested in exploring the PPARγ‐activating potential of natural products. In this manuscript, we will review the research progress of PPARγ agonists from natural products in recent years and probe into the application potential and prospects of PPARγ natural agonists in the therapy of various liver diseases, including inflammation, hepatic fibrosis, non‐alcoholic fatty liver and liver cancer.

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Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats

Cited by 32 publications

References 37 publications

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

CCl₄-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway

Therapeutic potential of PPARγ natural agonists in liver diseases

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Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats

Cited by 32 publications

References 37 publications

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

CCl4-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway

Therapeutic potential of PPARγ natural agonists in liver diseases

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CCl₄-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway