Moringa oleifera extract modulates the expression of fertility related genes and elevation of calcium ions in sheep oocytes

Barakat, Ibrahim A. H.; Khalil, Wagdy K. B.; Alhimaidi, Ahmad R.

doi:10.1016/j.smallrumres.2015.06.011

Cited by 14 publications

(12 citation statements)

References 46 publications

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“…Litter size and litter survival the rate of maturation of sheep oocytes and could act as a promoter to induce mRNA expressions and synthesis of essential proteins for the maturational processes(Barakat et al, 2015). Our results indicated that dietary MOL was able to improve litter size, litter birth weight, and litter survival.…”

mentioning

confidence: 67%

“…Odedire (2008) showed that rabbits receiving 100% Moringa diet had higher litter size, litter weight at birth and litter weight at weaning than those receiving 100% Centrosema. Additionally, it was also reported that in combination with hormone supplementation, MOL improved the rate of maturation of sheep oocytes and could act as a promoter to induce mRNA expressions and synthesis of essential proteins for the maturational processes (Barakat et al, 2015). have regulative effects in fertility performance (Jaiswal, Rai, Kumar, Mehta, & Watal, 2009;Vongsak, Sithisarn, & Gritsanapan, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…The hexane extract of MOL has been reported to enhance seminiferous tubule, epididymis, testis, and seminal vesicle functions in male mice (Cajuday & Pocsidio, 2010). In addition, Barakat, Khalil, and Al-Himaidi (2015) reported that MO combined with hormone supplementations improved the rate of maturation of sheep oocytes and could act as a promoter to induce mRNA expression and synthesis of essential proteins for the maturational processes.…”

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confidence: 99%

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The beneficial effects of Moringa oleifera leaf on reproductive performance in mice

Zeng

Luo

Wang

et al. 2019

Food Science & Nutrition

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Moringa oleifera is a tropical plant with high nutritional and medicinal value. Recent studies have reported its remarkable effects in inflammatory, antioxidative, and anti‐diabetes modulations, but there was no significant report on its role in animal breeding. In this study, we investigated the effects of dietary Moringa oleifera leaf (MOL) on reproductive performances in mice. We studied the reproductive performance of mice for six consecutive gestations. Mice fed with 4% MOL diet showed improved litter size, litter birth weight, and litter survivals until weaning age compared to control mice fed with normal diet (p < 0.05). Mice fed with MOL diet did not change weight and organ coefficients. Serum malondialdehyde (MDA) concentrations in both male and female mice were significantly decreased by dietary MOL (p < 0.05), but glutathione peroxidase (GSH‐PX) and superoxide dismutase (SOD) were unchanged. For male, dietary MOL significantly reduced sperm abnormality rate (p < 0.05) and Bcl2‐associated X protein (Bax) expression in testis (p < 0.05), but did not affect serum testosterone and the expression levels of androgen receptor (AR), phosphoglycerate kinase 2 (Pgk2), protamine2 (Prm2), and B cell leukemia/lymphoma 2 (Bcl2) in testis. For female, dietary MOL did not change serum estradiol and the expressions of estrogen receptor beta (ERβ), Bcl2, Bax, and vascular endothelial growth factor receptor (VEGFR) in ovary. In summary, MOL increased litter size and antioxidant ability, reduced the rate of sperm abnormality and the expression of Bax. Therefore, MOL may serve as a functional feed addictive for improving animal reproductive performance.

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confidence: 67%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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The beneficial effects of Moringa oleifera leaf on reproductive performance in mice

Zeng

Luo

Wang

et al. 2019

Food Science & Nutrition

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Section: Phytogenic Feed Additives and Assisted Reproductive Technology (Art)mentioning

confidence: 99%

“…In terms of assisted reproductive techniques for females, Barakat et al (2015) reported that the addition of M. oleifera extract to oocyte maturation medium improved the oocyte maturation rate in sheep. This beneficial action of M. oleifera extract could be used to enhance the synthesis of essential proteins, e.g., maturation promoting factor, for oocyte maturation processes ( Barakat et al, 2015 ). Additionally, this improvement could be related to the effect of M. oleifera extract in increasing calcium ions and modulating the expression of fertility-related genes in sheep oocytes ( Barakat et al, 2015 ).…”

Section: Phytogenic Feed Additives and Assisted Reproductive Technology (Art)mentioning

confidence: 99%

Effects of phytogenic feed additives on the reproductive performance of animals

Swelum

Hashem

Abdelnour

et al. 2021

Saudi Journal of Biological Sciences

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The reproductive performance of ruminants is economically significant, and its improvement is a primary goal of the livestock industry to ensure its sustainability. Several approaches have been developed to use phytogenics as feed additives for several proposes, such as reducing methane emissions, and as an alternative to antibiotics. Phytogenics have potent antioxidant, anti-inflammatory, immunomodulatory, and metabolism-regulatory properties, and they are present at high levels in animal feeds. This current review considers the potential use of medicinal herbs on the reproductive performance of animals. The influence of diet on the fertility complications commonly noted in ruminants is of global interest. Although the effects of phytogenics on ruminant digestion and absorption are well-explored, their impact on reproductive performance remains poorly investigated. This review focuses on the influence of phytogenics on semen quality, hormonal profiles, and hematobiochemical indices in male ruminants. Based on available data, phytogenics are perceived to improve oocyte quality, reproductive performance, and pregnancy. However, further more comprehensive research on the benefits and potential hazards of the use of phytogenics is required to improve reproductive performance in ruminants.

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Moringa oleifera leaf meal supplementation improves nutrient digestibility, milk yield, and reproductive performances in dairy cows during early lactation

Sahu,

Misra,

Baithalu

2023

Trop Anim Health Prod

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Moringa oleifera extract modulates the expression of fertility related genes and elevation of calcium ions in sheep oocytes

Cited by 14 publications

References 46 publications

The beneficial effects of Moringa oleifera leaf on reproductive performance in mice

The beneficial effects of Moringa oleifera leaf on reproductive performance in mice

Effects of phytogenic feed additives on the reproductive performance of animals

Moringa oleifera leaf meal supplementation improves nutrient digestibility, milk yield, and reproductive performances in dairy cows during early lactation

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