Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton's Lymphoma: An in vitro and in vivo study

Kumar, Sandeep; Verma, Praveen Kumar; Shukla, Alok; Singh, Rishi Kant; Patel, Anand Kumar; Yadav, Lokesh; Kumar, Sanjay; Kumar, Naveen; Kaushalendra,; Acharya, Arbind

doi:10.1016/j.jep.2022.115849

Cited by 19 publications

(13 citation statements)

References 42 publications

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“…Moringa plant (Moringa oleifera L. ), for food and medicines as well, widespread in the Indian sub-continent, Philippines, Central America, Saudi Arabia and the Caribbean Islands, has traditionally been used to treat cancer since ancient times [11]. This plant in Indonesia is more closely traced through the distribution and local knowledge of the Madurese people and is called Maronggi which is used daily as a food ingredient.…”

Section: Figure 2 Parts Of Plants That Are Used For Medicinesmentioning

confidence: 99%

“…Local knowledge of Madurese people related to its use as a medicinal ingredient, moringa is used to treat the eyes. Traditionally, Moringa oleifera has been used to treat hemorrhoids, fever, sore throat, eye and ear infections, ascites, rheumatism, poisonous bites, improving heart function, inflammation, liver disease, cancer, hematology, liver, and kidney function [11,[12][13][14].…”

Section: Figure 2 Parts Of Plants That Are Used For Medicinesmentioning

confidence: 99%

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Plant diversity and its potential in Sumenep, East Java, Indonesia

Susiarti,

Rugayah,

Oryzanti

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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It is well known that biological and cultural diversity in Indonesia is quite high, as well as the potential of plants as food, medicine, cosmetics, and dyes. This diversity gives rise to local knowledge in its interaction with the environment and the utilization of plant resources to the daily needs of local communities. The Local knowledge from a fairly diverse community still has much to be revealed. Similarly, Sumenep geographically consists of the mainland (54.79%) and the islands (45.21%) with 126 islands. Several field surveys in Sumenep have been conducted on several islands such as in Sepanjang, Gili Iyang, Poteran, Kangean, and Madura mainland, with interview methods to the majority of Madurese ethnic people. From the data collection so far, approximately 173 potential species of plants for food, medicinal ingredients, cosmetic ingredients, and coloring materials have been recorded. Food materials include Amorphophallus paeoniifolius, Moringa oleifera, Dioscorea alata, and Borassus flabellifer, as well as medicinal ingredients include Azadirachta indica, Curcuma aeruginosa, and Paederia foetida, whereas for natural dye is Ceriops tagal.

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Section: Figure 2 Parts Of Plants That Are Used For Medicinesmentioning

confidence: 99%

Section: Figure 2 Parts Of Plants That Are Used For Medicinesmentioning

confidence: 99%

Plant diversity and its potential in Sumenep, East Java, Indonesia

Susiarti,

Rugayah,

Oryzanti

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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“…Moringa leaves are effective as an antidiabetic (Chigurupati et al 2021). In vitro and in vivo studies confirmed various biological activities such as antioxidant (Mahmoud et al 2022), anti-inflammatory (Cuellar-Nunez et al 2021, antidiabetic (Mahmoud et al 2022), anticancer (Kumar et al 2023), cardioprotective (Aju et al 2020), hypocholesterolemic (Chen et al 2020), hepatoprotective (Asgari-Kafrani et al 2020;Fotio et al 2020), antihypertensive (Acuram 2019), and antibacterial (van den Berg and Kuipers 2022).…”

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confidence: 93%

“…So far, there have been no studies that reported the mutagenicity and carcinogenicity of moringa leaf powder since this ingredient is claimed scientifically as anticancer in many studies (Chigurupati et al 2021;Hassan et al 2021;Kumar et al 2023). The beneficial effect of moringa leaf powder and its use as an ingredient for functional foods should consider the toxicological effects, and the uses should be below the reported harmful doses.…”

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confidence: 99%

Potential of moringa (Moringa oleifera) leaf powder for functional food ingredients: A review

Ariani¹,

Estiasih²,

Sunarharum³

et al. 2023

Czech J. Food Sci.

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One of the efforts to produce functional foods is using ingredients containing health-beneficial bioactive compounds. Another way to produce functional foods is fermentation generating bioactive compounds or fortification with the bioactive compound extract. An ingredient historically believed to have benefits on health is moringa (Moringa oleifera) leaf powder. Moringa leaf powder is a valuable source of functional ingredients, including protein, vitamins, minerals, and phytonutrients such as carotenoids, tocopherols, polyphenols, flavonoids, alkaloids, and tannins. However, moringa is a plant that is distributed in various tropical countries in the world. Its quality depends on geographical differences, cultivars, environmental conditions, seasons, genotypes, and varieties. This article reviews the bioactive compounds of moringa leaf powder and the characteristics of moringa leaf powder extract. The effect of moringa leaf powder fortification on food product characteristics is also discussed. Moringa leaf powder possesses many pharmacological properties, such as anticancer, anti-inflammatory, hepatoprotective, cardioprotective, and antioxidant ones. The bioactivity of leaf extract is extracting solvent dependent. Therefore, fortification results in nutritional improvement and increasing health benefits of food products. However, the adverse effect is found in sensory. Thus properties, thus the moringa leaf powder fortification level usually is less than 10%. Changes in the functional properties of foods due to moringa leaf powder fortification have been studied to a limited extent. A low level of fortification might not affect the properties of food products. Therefore, moringa leaf powder is potentially used as a functional food ingredient. Some studies reported the toxicological effects of moringa leaf powder and the use of this ingredient, should be below the harmful doses.

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“…Te plant is distributed in subtropical and tropical areas and includes about 13 species [81]. Globally, MO is widely distributed over Africa, Asia, Central America, and the Caribbean islands [82,83]. MO in English is called the horseradish tree and drumstick tree; in Hindi, it is called Saijan; in Sanskrit, it is called Shigru [84].…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Abdelazim,

Afifi,

Abu-Alghayth

et al. 2024

Journal of Food Biochemistry

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Plants could be used for multiple medicinal purposes. Moringa oleifera (MO) is considered the most famous plant used for this purpose. The present review aimed to spot the light on the recent medicinal, biochemical, and nutritional applications of MO. The plant contains a huge number of nutrients such as fatty acids, amino acids, proteins, polysaccharides, minerals, and vitamins. It has been used to control glucose, lipids, proteins, minerals, vitamins, hormones, and antioxidants in many animals and human models. Its medicinal applications are also varied and wide; it could be used to control and manage lots of disorders. Extracts and isolated ingredients from the plant open the way for many researchers all over the world to study its biochemical and medicinal impact on many experimental and clinical models. The present review spots the light on the recent medicinal and biochemical significance of MO opening the discussion and demonstrating the strengths and weaknesses in the MO research area. Regardless of the contrary concept, we considered MO a promising plant that could be studied for its medicinal applications on both biochemical and molecular levels. We recommended further research on the molecular effects of MO in healthy and diseased models.

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Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton's Lymphoma: An in vitro and in vivo study

Cited by 19 publications

References 42 publications

Plant diversity and its potential in Sumenep, East Java, Indonesia

Plant diversity and its potential in Sumenep, East Java, Indonesia

Potential of moringa (Moringa oleifera) leaf powder for functional food ingredients: A review

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

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