Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Borgonovo, Gigliola; Petrocellis, Luciano De; Moriello, Aniello Schiano; Bertoli, Simona; Battezzati, Alberto; Mazzini, Stefania; Bassoli, Angela

doi:10.3390/molecules25040976

Cited by 37 publications

(24 citation statements)

References 55 publications

(58 reference statements)

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“…Reduction of the vascular permeability was also observed in this study (Dos Santos et al, 2018). Another in vitro program proved that moringin is a potent agonist of the TRPA1 channel (Borgonovo et al, 2020). Thus, the application of these analogs would benefit TMD treatment in a relatively safe way with few side effects.…”

Section: Moringa Oleifera Lamsupporting

confidence: 75%

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Cai

et al. 2021

Front. Pharmacol.

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Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be relieved by a variety of drugs through various delivery systems. In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy.

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Section: Moringa Oleifera Lamsupporting

confidence: 75%

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Cai

et al. 2021

Front. Pharmacol.

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“…The phytochemicals that have been recognized in the leaves of Moringa oleifera can be grouped in three main chemical families: flavonoids, biophenols and their derivatives, and glucosinolates (GLs) and their derivatives [23,24]. In particular, glucomoringin, belonging to the glucosinolate group, possesses several biological properties, being effective against oxidation, viruses, fungi and bacteria [25].…”

Section: Discussionmentioning

confidence: 99%

Moringa oleifera Leaf Powder as Functional Additive in Cookies to Protect SH-SY5Y Cells

et al. 2021

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The aim of this work is the evaluation of the addition of Moringa leaf powder (MLP) in cookies in terms of antioxidant properties, dough processability and sensorial properties of the cookies. The total content of biophenols and flavonoids in MLP was detected and the identification of the bioactive molecules was performed by HPLC-ESI-TOF-MS measurements, before and after oven treatment at 180 °C for 20 min. After a preliminary evaluation of the MLP water soluble fraction (MLPsf) cytotoxicity, its protective effect against an oxidative injury induced in the SH-SY5Y cells was assessed. Data evidence that the bioactive molecules present in MLPsf are effective in preventing ROS production and in protecting neuronal cells against oxidative stress. Prototypes of cookies containing MLP in different concentrations were then produced and evaluated by a consumer panel. Selected doughs containing MLP were analysed to determine the total content of biophenols in the cookies after baking and their enrichment in terms of valuable chemical elements. The influence of MLP on the viscoelastic behaviour and morphology of the doughs was also assessed. Finally, the potential role in counteracting the insurgence of not treatable neurodegenerative pathologies of two main MLP components, glucomoringin and kaempferol derivatives, present also after the thermal treatment, was discussed.

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“…Several Nrf2-interacting nutrients are direct TRPA1 activators [ 21 , 110 ]. These include: (i) allyl isothiocyanates (AITC: pungent components of mustard, horseradish, and wasabi [ 2 ]), (ii) cinnamaldehyde from cinnamon [ 70 ], (iii) allicin, an organosulfur compound from garlic [ 111 ], (iv) green tea polyphenols [ 112 , 113 ], and (v) 3 glucosinolates from Sisymbrium officinale (isopropylisothiocyanate and 2-buthylisothiocyanate) or Moringa oleifera (4-[(α-l-rhamnosyloxy) benzyl] isothiocyanate) [ 114 , 115 ]. Sulforaphane, an AITC and the most potent natural Nrf2 activator, does not appear to interact with TRPA1.…”

Section: Activation and Desensitization Of Trpa1 And Trpv1mentioning

confidence: 99%

Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19

Bousquet

Czarlewski²,

Zuberbier

et al. 2021

Int Arch Allergy Immunol

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In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.

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Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Cited by 37 publications

References 55 publications

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Moringa oleifera Leaf Powder as Functional Additive in Cookies to Protect SH-SY5Y Cells

Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19

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