Morphanthridines III. 6‐Basic substituted morphanthridines

Abstract

The reaction of hydrazines and amines with 6‐chloromorphanthridine was investigated. Grignard coupling of aminoalkyl halides with 6‐chloromorphanthridine afforded 6‐amino‐alkylmorphanthridines. Cyclization of 6‐(2‐chloroethylamino)morphanthridine yielded the new ring system 5′H‐imidazo[5, 6‐a]dibenz[b, ejazepine, which was aminoalkylated by generation of the 11‐position anion with butyllithium, followed by treatment with a tertiary aminoalkyl halide.