Morphine protects for head trauma induced cognitive deficits in mice

Zohar, Ofer; Getslev, V.; Miller, Ayelet L.; Schreiber, Shaul; Pick, Chaim G.

doi:10.1016/j.neulet.2005.10.099

Cited by 27 publications

(13 citation statements)

References 19 publications

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“…Currently, no other studies have been carried out combining MDMA and TBI in mice. Recent studies from our lab combined alcohol consumption before and during mTBI (Baratz et al 2010) or morphine injection prior to mTBI (Zohar et al 2006). In these experiments, both alcohol and morphine provided a neuroprotective effect in mTBI mice.…”

Section: Discussionmentioning

confidence: 99%

The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI)

et al. 2010

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Section: Discussionmentioning

confidence: 99%

The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI)

et al. 2010

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“…Nonetheless, several excellent animal models of concussive injury have recently been established (Gurkoff et al, 2006;Henninger et al, 2005;Milman et al, 2005;Tang et al, 1997;Tashlykov et al, 2007;Ucar et al, 2006;Yoshiyama et al, 2005;Zohar et al, 2003Zohar et al, , 2006. For example, Henninger et al (2005) modifying methods of Tang et al (1997) have used a weight drop device to the exposed skull that replicates human concussion.…”

Section: Animal Models Of Concussionmentioning

confidence: 99%

“…However, histology demonstrated several pathological changes including a reduction in the number of cortical neurons as well as in the hippocampus. A limitation of this study is that it only examined memory nine days postinjury but Milman et al (2005) and Zohar et al (2003Zohar et al ( , 2006 using somewhat similar methods, but in mice, have demonstrated these type of persistent cognitive differences in concussed animals for longer periods of time post-injury. Gurkoff et al (2006) have demonstrated this in rats with a fluid percussion injury model and Tashlykov et al (2007) have shown apoptotic changes in cerebral cortex and hippocampus using this weight drop technique as well.…”

Section: Animal Models Of Concussionmentioning

confidence: 99%

Neuropsychology and clinical neuroscience of persistent post-concussive syndrome

Bigler

2007

J Int Neuropsychol Soc

363

248

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On the mild end of the acquired brain injury spectrum, the terms concussion and mild traumatic brain injury (mTBI) have been used interchangeably, where persistent post-concussive syndrome (PPCS) has been a label given when symptoms persist for more than three months post-concussion. Whereas a brief history of concussion research is overviewed, the focus of this review is on the current status of PPCS as a clinical entity from the perspective of recent advances in the biomechanical modeling of concussion in human and animal studies, particularly directed at a better understanding of the neuropathology associated with concussion. These studies implicate common regions of injury, including the upper brainstem, base of the frontal lobe, hypothalamic-pituitary axis, medial temporal lobe, fornix, and corpus callosum. Limitations of current neuropsychological techniques for the clinical assessment of memory and executive function are explored and recommendations for improved research designs offered, that may enhance the study of long-term neuropsychological sequelae of concussion. (JINS, 2008, 14, 1-22.)

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“…Once injected, morphine enters the blood stream, which carries it to the brain and other parts of the body where it acts primarily as an agonist of the μ opioid receptors in the central nervous system and in peripheral tissue. [58][59][60] Recently, Holbrook et al demonstrated that the administration of morphine for optimal control of pain and anxiety after injury may reduce the risk of post-traumatic stress disorder. 61 …”

Section: Discussionmentioning

confidence: 99%

“…(4a)] and after IP morphine administration [ Fig. (4b)] at a dose of 10 mg∕kg of body weight, 59 20 min after injury. As can be seen in Fig.…”

Section: Figures 4(a) and 4(b)mentioning

confidence: 99%

Differential effects of early postinjury treatment with neuroprotective drugs in a mouse model using diffuse reflectance spectroscopy

Shochat

Abookasis

2015

Neurophoton

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Abstract. The time required for the arrival of an ambulance crew and administration of first aid is critical to clinical outcome, particularly in the case of head injury victims requiring neuroprotective drugs following a car accident, falls, and assaults. Short response times of the medical team, together with proper treatment, can limit injury severity and even save a life before transportation to the nearest medical center. We present a comparative evaluation of five different neuroprotective drugs frequently used in intensive care and operating units in the early phase following traumatic brain injury (TBI): hypertonic saline (HTS), mannitol, morphine, melatonin, and minocycline. The effectiveness of these drugs in terms of changes in brain tissue morphology (cell organelle size, density, distribution, etc.) and biochemical tissue properties (chromophores' content) was experimentally evaluated through analysis of the spectral reduced scattering and optical absorption coefficient parameters in the near-infrared (NIR) optical range (650 to 1000 nm). Experiments were conducted on anesthetized male mice subjected to a noninvasive closed head weight-drop model of focal TBI (n ¼ 50 and n ¼ 10 control) and monitored using an NIR diffuse reflectance spectroscopy system utilizing independent source-detector separation and location. After 10 min of baseline measurement, focal TBI was induced and measurements were conducted for 20 min. Subsequently, a neuroprotective drug was administrated and measurements were recorded for another 30 min. This work's major findings are threefold: first, minocycline was found to improve hemodynamic outcome at the earliest time postinjury. Second, HTS decreased brain water content and inhibited the increase in intracranial pressure. Third, the efficacy of neuroprotective drugs can be monitored noninvasively with diffuse reflectance spectroscopy. The demonstrated ability to noninvasively detect cerebral physiological properties following early administration of neuroprotective drugs underlines the need for more extensive investigation of the combined use of clinical drugs in larger-scale preclinical experiments to find the most beneficial drug treatment for brain injury patients.

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Morphine protects for head trauma induced cognitive deficits in mice

Cited by 27 publications

References 19 publications

The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI)

The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI)

Neuropsychology and clinical neuroscience of persistent post-concussive syndrome

Differential effects of early postinjury treatment with neuroprotective drugs in a mouse model using diffuse reflectance spectroscopy

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