Morphofunctional Evaluation of the Effect of Collagen-1-Based Dressing on Skin Regeneration after Burn Trauma in Mice of Two Genetic Strains

Abstract

Morphofunctional evaluation of the effect of biological dressing with collagen-1 on healing of 3A degree burn wound in outbred and mutant Hr(hr)/Hr(hr)(hairless) mice was carried out by the histological method and optic radioautography. A pronounced stimulatory effect of the dressing on skin regeneration in mice was demonstrated. According to radioautography data, early dressing of the burn wounds in Hr(hr)/Hr(hr)mice led to active proliferation of epithelial cells in dermal cyst and vascular endotheliocytes. The possible mechanisms of the stimulatory effect of collagen-based dressing on wound healing are discussed.

Morphofunctional Evaluation of the Effect of Transplantation of Allogeneic Fibroblasts on Healing of Burn Wounds in Albino Outbred Mice and Mutant Hr hr /Hr hr Mice

“…These fi ndings and the results of our previous studies [6] suggest that reparative regeneration of the skin in hairless mice carrying mutation in Hr gene has the same regularities as skin regeneration in outbred albino mice. No deviations from the normal were revealed during reparative regeneration of the derma in mutant mice.…”